Insights into Two Novel Orthopalladated Chromophores with Antimicrobial Activity against <i>Escherichia coli</i>
Advanced chromophoric tools, besides being biologically active, need to meet the expectations of the technological demands including stability, colour retention, and proper solubility for their target. Many coordination compounds of conjugated ligands are antibacterial dyes, able to combine a strong...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/18/6060 |
| _version_ | 1797484288038404096 |
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| author | Rosita Diana Francesco Silvio Gentile Antonio Carella Luigi Di Costanzo Barbara Panunzi |
| author_facet | Rosita Diana Francesco Silvio Gentile Antonio Carella Luigi Di Costanzo Barbara Panunzi |
| author_sort | Rosita Diana |
| collection | DOAJ |
| description | Advanced chromophoric tools, besides being biologically active, need to meet the expectations of the technological demands including stability, colour retention, and proper solubility for their target. Many coordination compounds of conjugated ligands are antibacterial dyes, able to combine a strong dyeing performance with a useful biological activity. Specifically, palladium (II) complexes of Schiff base ligands are known for their relevant activity against common bacteria. In this article, we report the synthesis and comprehensive experimental and theoretical characterization of two novel Pd(II) chromophore complexes obtained from a cyclopalladated Schiff base as two different chelating azo dyes. The antibacterial response of these two novel complexes was tested against the ubiquitous <i>Escherichia coli</i> bacterium in an aqueous medium and revealed a noteworthy antimicrobial activity, higher than when compared with their uncoordinated biologically active ligands. |
| first_indexed | 2024-03-09T23:00:21Z |
| format | Article |
| id | doaj.art-bcc65e0d1f1b495dbdfb96199f6a5f46 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:00:21Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bcc65e0d1f1b495dbdfb96199f6a5f462023-11-23T18:03:38ZengMDPI AGMolecules1420-30492022-09-012718606010.3390/molecules27186060Insights into Two Novel Orthopalladated Chromophores with Antimicrobial Activity against <i>Escherichia coli</i>Rosita Diana0Francesco Silvio Gentile1Antonio Carella2Luigi Di Costanzo3Barbara Panunzi4Department of Agricultural Sciences, University of Naples Federico II, Via Università, 100, 80055 Portici, ItalyDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, ItalyDepartment of Chemical Sciences, University of Napoli Federico II, Strada Comunale Cinthia, 26, 80126 Napoli, ItalyDepartment of Agricultural Sciences, University of Naples Federico II, Via Università, 100, 80055 Portici, ItalyDepartment of Agricultural Sciences, University of Naples Federico II, Via Università, 100, 80055 Portici, ItalyAdvanced chromophoric tools, besides being biologically active, need to meet the expectations of the technological demands including stability, colour retention, and proper solubility for their target. Many coordination compounds of conjugated ligands are antibacterial dyes, able to combine a strong dyeing performance with a useful biological activity. Specifically, palladium (II) complexes of Schiff base ligands are known for their relevant activity against common bacteria. In this article, we report the synthesis and comprehensive experimental and theoretical characterization of two novel Pd(II) chromophore complexes obtained from a cyclopalladated Schiff base as two different chelating azo dyes. The antibacterial response of these two novel complexes was tested against the ubiquitous <i>Escherichia coli</i> bacterium in an aqueous medium and revealed a noteworthy antimicrobial activity, higher than when compared with their uncoordinated biologically active ligands.https://www.mdpi.com/1420-3049/27/18/6060orthopalladatedchromophoresantimicrobiaDFT analyses |
| spellingShingle | Rosita Diana Francesco Silvio Gentile Antonio Carella Luigi Di Costanzo Barbara Panunzi Insights into Two Novel Orthopalladated Chromophores with Antimicrobial Activity against <i>Escherichia coli</i> Molecules orthopalladated chromophores antimicrobia DFT analyses |
| title | Insights into Two Novel Orthopalladated Chromophores with Antimicrobial Activity against <i>Escherichia coli</i> |
| title_full | Insights into Two Novel Orthopalladated Chromophores with Antimicrobial Activity against <i>Escherichia coli</i> |
| title_fullStr | Insights into Two Novel Orthopalladated Chromophores with Antimicrobial Activity against <i>Escherichia coli</i> |
| title_full_unstemmed | Insights into Two Novel Orthopalladated Chromophores with Antimicrobial Activity against <i>Escherichia coli</i> |
| title_short | Insights into Two Novel Orthopalladated Chromophores with Antimicrobial Activity against <i>Escherichia coli</i> |
| title_sort | insights into two novel orthopalladated chromophores with antimicrobial activity against i escherichia coli i |
| topic | orthopalladated chromophores antimicrobia DFT analyses |
| url | https://www.mdpi.com/1420-3049/27/18/6060 |
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