Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE<sub>2</sub> Production
<i>Ipomoea batatas</i> (L.) Lam., Convolvulaceae is widely distributed in Asian areas from tropical to warm-temperature regions. Their tubers are known for their antioxidant, anti-bacterial, anti-diabetic, wound healing, anti-inflammatory, and anti-ulcer activities. The preventive and th...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/12/1320 |
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| author | Ji-Yeong Bae Woo-Sung Park Hye-Jin Kim Ho-Soo Kim Kwon-Kyoo Kang Sang-Soo Kwak Mi-Jeong Ahn |
| author_facet | Ji-Yeong Bae Woo-Sung Park Hye-Jin Kim Ho-Soo Kim Kwon-Kyoo Kang Sang-Soo Kwak Mi-Jeong Ahn |
| author_sort | Ji-Yeong Bae |
| collection | DOAJ |
| description | <i>Ipomoea batatas</i> (L.) Lam., Convolvulaceae is widely distributed in Asian areas from tropical to warm-temperature regions. Their tubers are known for their antioxidant, anti-bacterial, anti-diabetic, wound healing, anti-inflammatory, and anti-ulcer activities. The preventive and therapeutic effects of orange-fleshed sweet potato on gastric ulcers have not been investigated. In this study, the carotenoid extract (CE) of orange-fleshed sweet potato was found to protect against gastric ulcers induced by HCl/ethanol in mice. The anti-inflammatory and antioxidant activities of the carotenoid pigment extract were also evaluated as possible evidence of their protective effects. Administration of CE reduced gastric ulcers. Oral administration of CE (100 mg/kg) protected against gastric ulcers by 78.1%, similar to the positive control, sucralfate (77.5%). CE showed potent reducing power and decreased nitric oxide production in a mouse macrophage cell line, RAW 264.7, in a concentration-dependent manner. The production of the inflammatory cytokine interleukin-6 and prostaglandin E<sub>2</sub> was also reduced by CE in a dose-dependent manner. The high carotenoid content of orange-fleshed sweet potato could play a role in its protective effect against gastric ulcers. This result suggests the possibility of developing functional products using this nutrient-fortified material. |
| first_indexed | 2024-03-10T03:20:42Z |
| format | Article |
| id | doaj.art-bcc6c69ead4b4ba6abbdf5f29bec084b |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:20:42Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-bcc6c69ead4b4ba6abbdf5f29bec084b2023-11-23T10:04:02ZengMDPI AGPharmaceuticals1424-82472021-12-011412132010.3390/ph14121320Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE<sub>2</sub> ProductionJi-Yeong Bae0Woo-Sung Park1Hye-Jin Kim2Ho-Soo Kim3Kwon-Kyoo Kang4Sang-Soo Kwak5Mi-Jeong Ahn6College of Pharmacy, Jeju Research Institute of Pharmaceutical Sciences and Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaPlant Systems Engineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, KoreaDivision of Horticultural Biotechnology, Hankyong National University, Anseong 17579, KoreaPlant Systems Engineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, Korea<i>Ipomoea batatas</i> (L.) Lam., Convolvulaceae is widely distributed in Asian areas from tropical to warm-temperature regions. Their tubers are known for their antioxidant, anti-bacterial, anti-diabetic, wound healing, anti-inflammatory, and anti-ulcer activities. The preventive and therapeutic effects of orange-fleshed sweet potato on gastric ulcers have not been investigated. In this study, the carotenoid extract (CE) of orange-fleshed sweet potato was found to protect against gastric ulcers induced by HCl/ethanol in mice. The anti-inflammatory and antioxidant activities of the carotenoid pigment extract were also evaluated as possible evidence of their protective effects. Administration of CE reduced gastric ulcers. Oral administration of CE (100 mg/kg) protected against gastric ulcers by 78.1%, similar to the positive control, sucralfate (77.5%). CE showed potent reducing power and decreased nitric oxide production in a mouse macrophage cell line, RAW 264.7, in a concentration-dependent manner. The production of the inflammatory cytokine interleukin-6 and prostaglandin E<sub>2</sub> was also reduced by CE in a dose-dependent manner. The high carotenoid content of orange-fleshed sweet potato could play a role in its protective effect against gastric ulcers. This result suggests the possibility of developing functional products using this nutrient-fortified material.https://www.mdpi.com/1424-8247/14/12/1320carotenoidorange-fleshed sweet potatogastric ulceranti-inflammatory activity |
| spellingShingle | Ji-Yeong Bae Woo-Sung Park Hye-Jin Kim Ho-Soo Kim Kwon-Kyoo Kang Sang-Soo Kwak Mi-Jeong Ahn Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE<sub>2</sub> Production Pharmaceuticals carotenoid orange-fleshed sweet potato gastric ulcer anti-inflammatory activity |
| title | Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE<sub>2</sub> Production |
| title_full | Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE<sub>2</sub> Production |
| title_fullStr | Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE<sub>2</sub> Production |
| title_full_unstemmed | Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE<sub>2</sub> Production |
| title_short | Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE<sub>2</sub> Production |
| title_sort | protective effect of carotenoid extract from orange fleshed sweet potato on gastric ulcer in mice by inhibition of no il 6 and pge sub 2 sub production |
| topic | carotenoid orange-fleshed sweet potato gastric ulcer anti-inflammatory activity |
| url | https://www.mdpi.com/1424-8247/14/12/1320 |
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