The therapeutic potential of triptolide and celastrol in neurological diseases

The therapeutic potential of triptolide and celastrol in neurological diseases

Neurological diseases are complex diseases affecting the brain and spinal cord, with numerous etiologies and pathogenesis not yet fully elucidated. Tripterygium wilfordii Hook. F. (TWHF) is a traditional Chinese medicine with a long history of medicinal use in China and is widely used to treat autoi...

Full description

Bibliographic Details
Main Authors:	Yueran Cui, Xuejiao Jiang, Juan Feng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Pharmacology
Subjects:	neurological diseases traditional Chinese medicine triptolide celastrol neuroprotection toxicity
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1024955/full

Similar Items

CYP450s-Activity Relations of Celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of <i>Tripterygium wilfordii</i>
by: Chunhuan Jin, et al.
Published: (2019-06-01)

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
by: Shao-Ru Chen, et al.
Published: (2018-02-01)

Recent advances in drug delivery of celastrol for enhancing efficiency and reducing the toxicity
by: Yuan Sun, et al.
Published: (2024-02-01)

Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity
by: Yaxin Cheng, et al.
Published: (2021-11-01)

Exploration of the effect of Celastrol on protein targets in nasopharyngeal carcinoma: Network pharmacology, molecular docking and experimental evaluations
by: Junjun Ling, et al.
Published: (2022-11-01)

Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine
by: Rui Sun, et al.
Published: (2022-04-01)

Palliative effects of metformin on testicular damage induced by triptolide in male rats
by: Ke Wang, et al.
Published: (2021-10-01)

The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy
by: Min Yan, et al.
Published: (2022-06-01)

Celastrol: A Potential Natural Lead Molecule for New Drug Design, Development and Therapy for Memory Impairment
by: Amir Yusri MA, et al.
Published: (2023-04-01)

Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies
by: Cheng Wang, et al.
Published: (2023-07-01)

Friend or foe? The dual role of triptolide in the liver, kidney, and heart
by: Shiyuan Jiang, et al.
Published: (2023-05-01)

Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
by: Rita Cascão, et al.
Published: (2017-06-01)

TP-CSO: A Triptolide Prodrug for Pancreatic Cancer Treatment
by: Xinlong Wang, et al.
Published: (2022-06-01)

Native Endophytes of Tripterygium wilfordii-Mediated Biotransformation Reduces Toxicity of Celastrol
by: Ping-yang Ma, et al.
Published: (2022-05-01)

Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential
by: Jia Gu, et al.
Published: (2023-08-01)

Triptolide mediates Wnt/β-catenin signalling pathway to reduce cerebral ischemia-reperfusion injury in rats
by: Wenyong Pan, et al.
Published: (2021-01-01)

A single-cell landscape of triptolide-associated testicular toxicity in mice
by: Wei Zhang, et al.
Published: (2023-08-01)

In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration
by: Huahui Zeng, et al.
Published: (2020-01-01)

Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer
by: Xiaohu Zeng, et al.
Published: (2022-12-01)

Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders
by: Hang Zhao, et al.
Published: (2023-06-01)

Triptolide and l-ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation
by: Man Li, et al.
Published: (2022-12-01)

Lipidomic Profiling of Ipsilateral Brain and Plasma after Celastrol Post-Treatment in Transient Middle Cerebral Artery Occlusion Mice Model
by: Maozhu Liu, et al.
Published: (2021-07-01)

Novel Carboxylated Chitosan-Based Triptolide Conjugate for the Treatment of Rheumatoid Arthritis
by: Lan Zhang, et al.
Published: (2020-02-01)

Chinese Medicine in the Battle Against Obesity and Metabolic Diseases
by: Lingyan Xu, et al.
Published: (2018-07-01)

Therapeutic Potential of Triptolide in Treating Bone-Related Disorders
by: Wu Gang, et al.
Published: (2022-06-01)

Nanotechnology-Based Celastrol Formulations and Their Therapeutic Applications
by: Pushkaraj Rajendra Wagh, et al.
Published: (2021-06-01)

Celastrol alleviates arthritis by modulating the inflammatory activities of neutrophils
by: Kai Yuan, et al.
Published: (2017-01-01)

The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review
by: Peng Liu, et al.
Published: (2021-09-01)

Advances on Effects of Triptolide with Non-small Cell Lung Cancer
by: Li WANG, et al.
Published: (2013-07-01)

Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-κB Signaling Pathway
by: Bo Zhang, et al.
Published: (2020-08-01)

Fabrication of novel vesicles of triptolide for antirheumatoid activity with reduced toxicity in vitro and in vivo
by: Zhang L, et al.
Published: (2016-06-01)

Corrigendum: Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-κB Signaling Pathway
by: Bo Zhang, et al.
Published: (2021-07-01)

A mini-review of traditional Chinese medicines on liver diseases
by: Siu Kan Law, et al.
Published: (2023-06-01)

Macrophage malfunction in Triptolide-induced indirect hepatotoxicity
by: Tingting Qin, et al.
Published: (2022-09-01)

Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis
by: Peng Gao, et al.
Published: (2024-02-01)

The Therapeutic Potential of Celastrol in Central Nervous System Disorders: Highlights from In Vitro and In Vivo Approaches
by: Stefania Schiavone, et al.
Published: (2021-08-01)

A novel strategy to enhance terpenoids production using cambial meristematic cells of Tripterygium wilfordii Hook. f.
by: Yadi Song, et al.
Published: (2019-11-01)

Celastrol Supplementation Ablates Sexual Dimorphism of Abdominal Aortic Aneurysm Formation in Mice
by: Aida Javidan, et al.
Published: (2023-03-01)

Synthesis and anticancer properties of celastrol derivatives involved in the inhibition of VEGF
by: Mingxia Song, et al.
Published: (2023-12-01)

The molecular pathogenesis of triptolide-induced hepatotoxicity
by: Yeqing Hu, et al.
Published: (2022-08-01)