Chronic toxicity of six pesticides mixture traces on biochemical, hematological, and histological parameters of liver and kidney in female Wistar rats
Introduction. The modern world uses several toxic chemicals, among them, pesticides which present a potential risk to humans when they are exposed to many pesticides at the same time through diet. Objective. The present study aimed to eva-luate the toxic effect of six pesticides mixture on liver hem...
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Société Algérienne de Nutrition
2022-12-01
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| Series: | Nutrition & Santé |
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| Online Access: | http://www.nutrition-sante.dz/articles/chronic-toxicity-of-six-pesticides-mixture-traces-on-biochemical-hematological-and-histological-parameters-of-liver-and-kidney-in-female-wistar-rats-hichem-bellala-fadhela-mahamed-mahmoud |
| _version_ | 1797951817044197376 |
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| author | Hichem BELLALA Fadhela MAHAMED MAHMOUD Amel HADJ ZIANE Arezki BITAM |
| author_facet | Hichem BELLALA Fadhela MAHAMED MAHMOUD Amel HADJ ZIANE Arezki BITAM |
| author_sort | Hichem BELLALA |
| collection | DOAJ |
| description | Introduction. The modern world uses several toxic chemicals, among them, pesticides which present a potential risk to humans when they are exposed to many pesticides at the same time through diet. Objective. The present study aimed to eva-luate the toxic effect of six pesticides mixture on liver hematological, biochemical and histopathological parameters, in rats. Material and methods. Female Wistar rats, aged two months and weighed 150±5 g, were divided into three groups of ten rats. Pesticides mixture (Chloroperiphos-methyl, Deltamethrin, Methidathion, Cypermethrin, Acetami-prid, and Abamectin), at Acceptable Daily Intake (ADI and ADI×2), was administered orally for 7 months. Results. Pesticides mixture at ADI exposed rats exhibited severe damage in liver and kidney structure and function. At dose of ADI×2, more severe effects, with notable changes and damage, were observed in liver and kidney histology by several forms of inflammation, denaturation, and necrosis of cells and tissues. This showed direct impact on functioning and metabolism of these organs by significant changes in biochemical and haematological parameters (total cholesterol, total proteins, aspartate-aminotransferase, alanine-aminotransferase, alkaline phosphatase, gamma-glutamiltransferase, total bilirubin, potassium, iron, urea, creatinine, uric acid, hemoglo-bin and hematocrit). Conclusion. The six pesticides mixture is toxic at ADI×2, and even at ADI that represents security dose of one pesticide. However, in a mixture, this dose causes deleterious effects on liver and kidney structure and function in rats. |
| first_indexed | 2024-04-10T22:36:33Z |
| format | Article |
| id | doaj.art-bcc85d0c37344b9dbb49fbabf94a849b |
| institution | Directory Open Access Journal |
| issn | 2253-0983 2353-026X |
| language | English |
| last_indexed | 2024-04-10T22:36:33Z |
| publishDate | 2022-12-01 |
| publisher | Société Algérienne de Nutrition |
| record_format | Article |
| series | Nutrition & Santé |
| spelling | doaj.art-bcc85d0c37344b9dbb49fbabf94a849b2023-01-16T12:25:27ZengSociété Algérienne de NutritionNutrition & Santé2253-09832353-026X2022-12-01110211912910.30952/ns.11.2.8Chronic toxicity of six pesticides mixture traces on biochemical, hematological, and histological parameters of liver and kidney in female Wistar ratsHichem BELLALA0Fadhela MAHAMED MAHMOUD1Amel HADJ ZIANE2Arezki BITAM31Faculty of Nature and life sciences, Department of Food Sciences, University Saad Dahlab of Blida, P.O. Box 270, 09000 Blida, Algeria. 2Laboratory of Chemical Enginee-ring, University Saad Dahlab of Blida, P.O. Box 270, 09000 Blida, AlgeriaLaboratory of Chemical Enginee-ring, University Saad Dahlab of Blida, P.O. Box 270, 09000 Blida, AlgeriaLaboratory of Chemical Enginee-ring, University Saad Dahlab of Blida, P.O. Box 270, 09000 Blida, AlgeriaNational Higher School of Agronomy, El Harrach, AlgeriaIntroduction. The modern world uses several toxic chemicals, among them, pesticides which present a potential risk to humans when they are exposed to many pesticides at the same time through diet. Objective. The present study aimed to eva-luate the toxic effect of six pesticides mixture on liver hematological, biochemical and histopathological parameters, in rats. Material and methods. Female Wistar rats, aged two months and weighed 150±5 g, were divided into three groups of ten rats. Pesticides mixture (Chloroperiphos-methyl, Deltamethrin, Methidathion, Cypermethrin, Acetami-prid, and Abamectin), at Acceptable Daily Intake (ADI and ADI×2), was administered orally for 7 months. Results. Pesticides mixture at ADI exposed rats exhibited severe damage in liver and kidney structure and function. At dose of ADI×2, more severe effects, with notable changes and damage, were observed in liver and kidney histology by several forms of inflammation, denaturation, and necrosis of cells and tissues. This showed direct impact on functioning and metabolism of these organs by significant changes in biochemical and haematological parameters (total cholesterol, total proteins, aspartate-aminotransferase, alanine-aminotransferase, alkaline phosphatase, gamma-glutamiltransferase, total bilirubin, potassium, iron, urea, creatinine, uric acid, hemoglo-bin and hematocrit). Conclusion. The six pesticides mixture is toxic at ADI×2, and even at ADI that represents security dose of one pesticide. However, in a mixture, this dose causes deleterious effects on liver and kidney structure and function in rats.http://www.nutrition-sante.dz/articles/chronic-toxicity-of-six-pesticides-mixture-traces-on-biochemical-hematological-and-histological-parameters-of-liver-and-kidney-in-female-wistar-rats-hichem-bellala-fadhela-mahamed-mahmoudpesticidestoxicitybiochemistryhistopathologyliverkidneyrat |
| spellingShingle | Hichem BELLALA Fadhela MAHAMED MAHMOUD Amel HADJ ZIANE Arezki BITAM Chronic toxicity of six pesticides mixture traces on biochemical, hematological, and histological parameters of liver and kidney in female Wistar rats Nutrition & Santé pesticides toxicity biochemistry histopathology liver kidney rat |
| title | Chronic toxicity of six pesticides mixture traces on biochemical, hematological, and histological parameters of liver and kidney in female Wistar rats |
| title_full | Chronic toxicity of six pesticides mixture traces on biochemical, hematological, and histological parameters of liver and kidney in female Wistar rats |
| title_fullStr | Chronic toxicity of six pesticides mixture traces on biochemical, hematological, and histological parameters of liver and kidney in female Wistar rats |
| title_full_unstemmed | Chronic toxicity of six pesticides mixture traces on biochemical, hematological, and histological parameters of liver and kidney in female Wistar rats |
| title_short | Chronic toxicity of six pesticides mixture traces on biochemical, hematological, and histological parameters of liver and kidney in female Wistar rats |
| title_sort | chronic toxicity of six pesticides mixture traces on biochemical hematological and histological parameters of liver and kidney in female wistar rats |
| topic | pesticides toxicity biochemistry histopathology liver kidney rat |
| url | http://www.nutrition-sante.dz/articles/chronic-toxicity-of-six-pesticides-mixture-traces-on-biochemical-hematological-and-histological-parameters-of-liver-and-kidney-in-female-wistar-rats-hichem-bellala-fadhela-mahamed-mahmoud |
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