High Prevalence of Untreated and Undertreated Vitamin D Deficiency and Insufficiency in Patients with Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) patients with vitamin D deficiency show an increased risk of hospital admission, surgery, and loss of response to biologic therapy while high vitamin D levels are identified as a protective factor. Our goal was to investigate the prevalence of untreated and undertrea...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2020-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/351943 |
| _version_ | 1797207233039171584 |
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| author | Viktor Domislović Darija Vranešić Bender Ana Barišić Marko Brinar Dina Ljubas Kelečić Cecilija Rotim Martin Novosel Marija Matašin Željko Krznarić |
| author_facet | Viktor Domislović Darija Vranešić Bender Ana Barišić Marko Brinar Dina Ljubas Kelečić Cecilija Rotim Martin Novosel Marija Matašin Željko Krznarić |
| author_sort | Viktor Domislović |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) patients with vitamin D deficiency show an increased risk of hospital admission, surgery, and loss of response to biologic therapy while high vitamin D levels are identified as a protective factor. Our goal was to investigate the prevalence of untreated and undertreated vitamin D deficiency and factors associated with vitamin D deficiency. In this cross-sectional study, we measured serum vitamin D in a random sample of Caucasian IBD patients. Vitamin D deficiency was defined as <50 nmol/L and insufficiency as 50-75 nmol/L. Supplementation was defined as taking 800-2000 IU vitamin D daily. Untreated patients were defined as not taking supplementation and undertreated group as receiving supplementation but showing vitamin D deficiency or insufficiency despite treatment. Our study included 185 IBD patients, i.e. 126 (68.1%) with Crohn’s disease (CD) and 59 (31.9%) with ulcerative colitis (UC). Overall, 108 (58.4%) patients had vitamin D deficiency and 60 (32.4%) patients vitamin D insufficiency. There were 16 (14.8%) and 11 (18.3%) treated patients in vitamin D deficiency and vitamin D insufficiency group, respectively.
The rate of untreated patients was 81.7% (n=49) in vitamin D deficiency group and 85.2% (n=92) in vitamin D insufficiency group. Tumor necrosis factor alpha inhibitors were associated with higher
serum vitamin D levels in CD and UC, and ileal involvement, ileal and ileocolonic resection with lower levels. In conclusion, not only is vitamin D deficiency common in IBD patients but the proportion of untreated and undertreated patients is considerably high. We suggest regular monitoring of vitamin D levels in IBD patients regardless of receiving vitamin D supplementation therapy. |
| first_indexed | 2024-04-24T09:19:39Z |
| format | Article |
| id | doaj.art-bcc8a9b0035148199cf7ebdc11efe08f |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:19:39Z |
| publishDate | 2020-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-bcc8a9b0035148199cf7ebdc11efe08f2024-04-15T16:21:52ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512020-01-0159.1.10911710.20471/acc.2020.59.01.13High Prevalence of Untreated and Undertreated Vitamin D Deficiency and Insufficiency in Patients with Inflammatory Bowel DiseaseViktor Domislović0Darija Vranešić Bender1Ana Barišić2Marko Brinar3Dina Ljubas Kelečić4Cecilija Rotim5Martin Novosel6Marija Matašin7Željko Krznarić8Division of Gastroenterology and Hepatology, Department of Internal Medicine, Zagreb University Hospital Centre, Zagreb, CroatiaUnit of Clinical Nutrition, Zagreb University Hospital Centre, Zagreb, Croatia; Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, CroatiaUnit of Clinical Nutrition, Zagreb University Hospital Centre, Zagreb, CroatiaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Zagreb University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, CroatiaUnit of Clinical Nutrition, Zagreb University Hospital Centre, Zagreb, CroatiaAndrija Štampar Teaching Institute of Public Health, Zagreb, CroatiaSchool of Medicine, University of Zagreb, Zagreb, CroatiaSchool of Medicine, University of Zagreb, Zagreb, CroatiaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Zagreb University Hospital Centre, Zagreb, Croatia; Unit of Clinical Nutrition, Zagreb University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, CroatiaInflammatory bowel disease (IBD) patients with vitamin D deficiency show an increased risk of hospital admission, surgery, and loss of response to biologic therapy while high vitamin D levels are identified as a protective factor. Our goal was to investigate the prevalence of untreated and undertreated vitamin D deficiency and factors associated with vitamin D deficiency. In this cross-sectional study, we measured serum vitamin D in a random sample of Caucasian IBD patients. Vitamin D deficiency was defined as <50 nmol/L and insufficiency as 50-75 nmol/L. Supplementation was defined as taking 800-2000 IU vitamin D daily. Untreated patients were defined as not taking supplementation and undertreated group as receiving supplementation but showing vitamin D deficiency or insufficiency despite treatment. Our study included 185 IBD patients, i.e. 126 (68.1%) with Crohn’s disease (CD) and 59 (31.9%) with ulcerative colitis (UC). Overall, 108 (58.4%) patients had vitamin D deficiency and 60 (32.4%) patients vitamin D insufficiency. There were 16 (14.8%) and 11 (18.3%) treated patients in vitamin D deficiency and vitamin D insufficiency group, respectively. The rate of untreated patients was 81.7% (n=49) in vitamin D deficiency group and 85.2% (n=92) in vitamin D insufficiency group. Tumor necrosis factor alpha inhibitors were associated with higher serum vitamin D levels in CD and UC, and ileal involvement, ileal and ileocolonic resection with lower levels. In conclusion, not only is vitamin D deficiency common in IBD patients but the proportion of untreated and undertreated patients is considerably high. We suggest regular monitoring of vitamin D levels in IBD patients regardless of receiving vitamin D supplementation therapy.https://hrcak.srce.hr/file/351943Inflammatory bowel diseasesVitamin D deficiencyCrohn’s diseaseColitis, ulcerative |
| spellingShingle | Viktor Domislović Darija Vranešić Bender Ana Barišić Marko Brinar Dina Ljubas Kelečić Cecilija Rotim Martin Novosel Marija Matašin Željko Krznarić High Prevalence of Untreated and Undertreated Vitamin D Deficiency and Insufficiency in Patients with Inflammatory Bowel Disease Acta Clinica Croatica Inflammatory bowel diseases Vitamin D deficiency Crohn’s disease Colitis, ulcerative |
| title | High Prevalence of Untreated and Undertreated Vitamin D Deficiency and Insufficiency in Patients with Inflammatory Bowel Disease |
| title_full | High Prevalence of Untreated and Undertreated Vitamin D Deficiency and Insufficiency in Patients with Inflammatory Bowel Disease |
| title_fullStr | High Prevalence of Untreated and Undertreated Vitamin D Deficiency and Insufficiency in Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | High Prevalence of Untreated and Undertreated Vitamin D Deficiency and Insufficiency in Patients with Inflammatory Bowel Disease |
| title_short | High Prevalence of Untreated and Undertreated Vitamin D Deficiency and Insufficiency in Patients with Inflammatory Bowel Disease |
| title_sort | high prevalence of untreated and undertreated vitamin d deficiency and insufficiency in patients with inflammatory bowel disease |
| topic | Inflammatory bowel diseases Vitamin D deficiency Crohn’s disease Colitis, ulcerative |
| url | https://hrcak.srce.hr/file/351943 |
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