Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals

Abstract Occupational exposure to numerous individual chemicals has been associated with olfactory dysfunction, mainly in individual case descriptions. Comprehensive epidemiological investigations into the olfactotoxic effect of working substances show that the human sense of smell may be impaired b...

Full description

Bibliographic Details
Main Authors: Sabine Werner, Eberhard Nies
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Occupational Medicine and Toxicology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12995-018-0209-6
_version_ 1811301528699404288
author Sabine Werner
Eberhard Nies
author_facet Sabine Werner
Eberhard Nies
author_sort Sabine Werner
collection DOAJ
description Abstract Occupational exposure to numerous individual chemicals has been associated with olfactory dysfunction, mainly in individual case descriptions. Comprehensive epidemiological investigations into the olfactotoxic effect of working substances show that the human sense of smell may be impaired by exposure to metal compounds involving cadmium, chromium and nickel, and to formaldehyde. This conclusion is supported by the results of animal experiments. The level of evidence for a relationship between olfactory dysfunction and workplace exposure to other substances is relatively weak.
first_indexed 2024-04-13T07:11:41Z
format Article
id doaj.art-bcca94cc09724d6084c9e979c30925ce
institution Directory Open Access Journal
issn 1745-6673
language English
last_indexed 2024-04-13T07:11:41Z
publishDate 2018-09-01
publisher BMC
record_format Article
series Journal of Occupational Medicine and Toxicology
spelling doaj.art-bcca94cc09724d6084c9e979c30925ce2022-12-22T02:56:52ZengBMCJournal of Occupational Medicine and Toxicology1745-66732018-09-0113112610.1186/s12995-018-0209-6Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicalsSabine Werner0Eberhard Nies1Institute for Occupational Safety and Health of the German Social Accident Insurance, Unit Toxicology of Industrial ChemicalsInstitute for Occupational Safety and Health of the German Social Accident Insurance, Unit Toxicology of Industrial ChemicalsAbstract Occupational exposure to numerous individual chemicals has been associated with olfactory dysfunction, mainly in individual case descriptions. Comprehensive epidemiological investigations into the olfactotoxic effect of working substances show that the human sense of smell may be impaired by exposure to metal compounds involving cadmium, chromium and nickel, and to formaldehyde. This conclusion is supported by the results of animal experiments. The level of evidence for a relationship between olfactory dysfunction and workplace exposure to other substances is relatively weak.http://link.springer.com/article/10.1186/s12995-018-0209-6Chemically induced anosmiaFormaldehydeMetalsOccupational exposureOlfaction disorders
spellingShingle Sabine Werner
Eberhard Nies
Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals
Journal of Occupational Medicine and Toxicology
Chemically induced anosmia
Formaldehyde
Metals
Occupational exposure
Olfaction disorders
title Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals
title_full Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals
title_fullStr Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals
title_full_unstemmed Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals
title_short Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals
title_sort olfactory dysfunction revisited a reappraisal of work related olfactory dysfunction caused by chemicals
topic Chemically induced anosmia
Formaldehyde
Metals
Occupational exposure
Olfaction disorders
url http://link.springer.com/article/10.1186/s12995-018-0209-6
work_keys_str_mv AT sabinewerner olfactorydysfunctionrevisitedareappraisalofworkrelatedolfactorydysfunctioncausedbychemicals
AT eberhardnies olfactorydysfunctionrevisitedareappraisalofworkrelatedolfactorydysfunctioncausedbychemicals