A live yeast supplementation to gestating ewes improves bioactive molecule composition in colostrum with no impact on its bacterial composition and beneficially affects immune status of the offspring
Colostrum quality is of paramount importance in the management of optimal ruminant growth and infectious disease prevention in early life. Live yeast supplementation effect during the last month of gestation was evaluated on ewes’ colostrum composition. Two groups of ewes (n = 14) carrying twin lamb...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679022000039/type/journal_article |
| _version_ | 1811155939845210112 |
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| author | Lysiane Dunière Justin B. Renaud Michael A. Steele Caroline S. Achard Evelyne Forano Frédérique Chaucheyras-Durand |
| author_facet | Lysiane Dunière Justin B. Renaud Michael A. Steele Caroline S. Achard Evelyne Forano Frédérique Chaucheyras-Durand |
| author_sort | Lysiane Dunière |
| collection | DOAJ |
| description | Colostrum quality is of paramount importance in the management of optimal ruminant growth and infectious disease prevention in early life. Live yeast supplementation effect during the last month of gestation was evaluated on ewes’ colostrum composition. Two groups of ewes (n = 14) carrying twin lambs were constituted and twins were separated into groups (mothered or artificially fed) 12 h after birth. Nutrient, oligosaccharides (OS), IgG and lactoferrin concentrations were measured over 72 h after lambing, and bacterial community was described in colostrum collected at parturition (T0). Immune passive transfer was evaluated through IgG measurement in lamb serum. In both groups, colostral nutrient, OS concentrations and IgG concentrations in colostrum and lamb serum decreased over time (P < 0⋅01), except for lactose, which slightly increased (P < 0⋅001), and lactoferrin, which remained stable. Bacterial population was stable over time with high relative abundances of Aerococcaceae, Corynebacteriaceae, Moraxellaceae and Staphylococcaceae in T0 colostrum. No effect of supplementation was observed in nutrient and lactoferrin concentrations. In supplemented ewes, the level of colostral IgG was higher at T0 and a higher level of serum IgG was observed in lambs born from supplemented mothers and artificially fed, while no effect of supplementation was observed in the mothered lamb groups. Using a metabolomic approach, we showed that supplementation affected OS composition with significantly higher levels of colostral Neu-5Gc compounds up to 5 h after birth. No effect of supplementation was observed on bacterial composition. Our data suggest that live yeast supplementation offsets the negative impact of early separation and incomplete colostrum feeding in neonate lambs. |
| first_indexed | 2024-04-10T04:43:19Z |
| format | Article |
| id | doaj.art-bccb325a8cde4c4482f6d012ce99c91c |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:43:19Z |
| publishDate | 2022-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-bccb325a8cde4c4482f6d012ce99c91c2023-03-09T12:38:46ZengCambridge University PressJournal of Nutritional Science2048-67902022-01-011110.1017/jns.2022.3A live yeast supplementation to gestating ewes improves bioactive molecule composition in colostrum with no impact on its bacterial composition and beneficially affects immune status of the offspringLysiane Dunière0https://orcid.org/0000-0003-2918-896XJustin B. Renaud1Michael A. Steele2Caroline S. Achard3Evelyne Forano4Frédérique Chaucheyras-Durand5Lallemand SAS, 19 rue des Briquetiers, BP 59, 31702 Blagnac cedex, France Université Clermont Auvergne, INRAE, UMR 454 MEDIS, 63122 Saint-Genès Champanelle, FranceLondon Research and Development Center, Agriculture and Agri-Food Canada, London, ON N5 V 4T3, CanadaDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, CanadaLallemand SAS, 19 rue des Briquetiers, BP 59, 31702 Blagnac cedex, France GenPhySE, Université de Toulouse, INRAE, INPT, ENVT, F-31320 Castanet Tolosan, FranceUniversité Clermont Auvergne, INRAE, UMR 454 MEDIS, 63122 Saint-Genès Champanelle, FranceLallemand SAS, 19 rue des Briquetiers, BP 59, 31702 Blagnac cedex, France Université Clermont Auvergne, INRAE, UMR 454 MEDIS, 63122 Saint-Genès Champanelle, FranceColostrum quality is of paramount importance in the management of optimal ruminant growth and infectious disease prevention in early life. Live yeast supplementation effect during the last month of gestation was evaluated on ewes’ colostrum composition. Two groups of ewes (n = 14) carrying twin lambs were constituted and twins were separated into groups (mothered or artificially fed) 12 h after birth. Nutrient, oligosaccharides (OS), IgG and lactoferrin concentrations were measured over 72 h after lambing, and bacterial community was described in colostrum collected at parturition (T0). Immune passive transfer was evaluated through IgG measurement in lamb serum. In both groups, colostral nutrient, OS concentrations and IgG concentrations in colostrum and lamb serum decreased over time (P < 0⋅01), except for lactose, which slightly increased (P < 0⋅001), and lactoferrin, which remained stable. Bacterial population was stable over time with high relative abundances of Aerococcaceae, Corynebacteriaceae, Moraxellaceae and Staphylococcaceae in T0 colostrum. No effect of supplementation was observed in nutrient and lactoferrin concentrations. In supplemented ewes, the level of colostral IgG was higher at T0 and a higher level of serum IgG was observed in lambs born from supplemented mothers and artificially fed, while no effect of supplementation was observed in the mothered lamb groups. Using a metabolomic approach, we showed that supplementation affected OS composition with significantly higher levels of colostral Neu-5Gc compounds up to 5 h after birth. No effect of supplementation was observed on bacterial composition. Our data suggest that live yeast supplementation offsets the negative impact of early separation and incomplete colostrum feeding in neonate lambs.https://www.cambridge.org/core/product/identifier/S2048679022000039/type/journal_articleColostrumGestating ewesImmunityLive yeast probioticOligosaccharides |
| spellingShingle | Lysiane Dunière Justin B. Renaud Michael A. Steele Caroline S. Achard Evelyne Forano Frédérique Chaucheyras-Durand A live yeast supplementation to gestating ewes improves bioactive molecule composition in colostrum with no impact on its bacterial composition and beneficially affects immune status of the offspring Journal of Nutritional Science Colostrum Gestating ewes Immunity Live yeast probiotic Oligosaccharides |
| title | A live yeast supplementation to gestating ewes improves bioactive molecule composition in colostrum with no impact on its bacterial composition and beneficially affects immune status of the offspring |
| title_full | A live yeast supplementation to gestating ewes improves bioactive molecule composition in colostrum with no impact on its bacterial composition and beneficially affects immune status of the offspring |
| title_fullStr | A live yeast supplementation to gestating ewes improves bioactive molecule composition in colostrum with no impact on its bacterial composition and beneficially affects immune status of the offspring |
| title_full_unstemmed | A live yeast supplementation to gestating ewes improves bioactive molecule composition in colostrum with no impact on its bacterial composition and beneficially affects immune status of the offspring |
| title_short | A live yeast supplementation to gestating ewes improves bioactive molecule composition in colostrum with no impact on its bacterial composition and beneficially affects immune status of the offspring |
| title_sort | live yeast supplementation to gestating ewes improves bioactive molecule composition in colostrum with no impact on its bacterial composition and beneficially affects immune status of the offspring |
| topic | Colostrum Gestating ewes Immunity Live yeast probiotic Oligosaccharides |
| url | https://www.cambridge.org/core/product/identifier/S2048679022000039/type/journal_article |
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