Evaluation of antioxidant, anti-cancer and anti-inflammatory characteristics of bio-synthesized silver nanoparticles produced by waste extract of Rheum ribes L.
Background: This study was designed to evaluate the antioxidant, anti-inflammation and anti-cancer potency of silver nanoparticles produced by waste Rheum ribes L. extract. Materials and Methods: in this study, 10 gr of dried Rheum ribes L powder after 3 hours dissolving at 37°C was filtered and a...
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| Format: | Article |
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Kashan University of Medical Sciences and Health Services
2019-08-01
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| Series: | Fiyz̤ |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-3795-en.html |
| _version_ | 1811248962112323584 |
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| author | Zahra Naeimi Ali Neamati Masoud Homayouni-Tabrizi |
| author_facet | Zahra Naeimi Ali Neamati Masoud Homayouni-Tabrizi |
| author_sort | Zahra Naeimi |
| collection | DOAJ |
| description | Background: This study was designed to evaluate the antioxidant, anti-inflammation and anti-cancer potency of silver nanoparticles produced by waste Rheum ribes L. extract.
Materials and Methods: in this study, 10 gr of dried Rheum ribes L powder after 3 hours dissolving at 37°C was filtered and applied for silver nanoparticles preparation. Particle size, X-ray diffractometer (XRD), Fourier transform infrared radiometer (FT-IR) and transmission electron microscope (TEM) methods were used to measurement the properties of silver nanoparticles. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) method accompanied by 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) compounds were used to evaluate the cytotoxicity and antioxidant capacity of the nanoparticles.
Results: The size of the produced silver nanoparticles was 28 nm with a uniform distribution and spherical appearance. The effective antioxidant dose for the ABTS and DPPH compounds was 200 µg/ml, and the obtained IC50 on HDF, Huvec, and MCF-7 cells for 24, 48 and 72 hours treatment were 30, 25, 12; 13.2, 11, 10; and 10, 9 and 8 µg/ml, respectively. Conclusion: The silver nanoparticles produced by waste Rheum ribes L. extract can have potential for use as a therapeutic strategy against cancer. |
| first_indexed | 2024-04-12T15:37:00Z |
| format | Article |
| id | doaj.art-bcceffb423d9463e860b92260fad652e |
| institution | Directory Open Access Journal |
| issn | 1029-7855 2008-9821 |
| language | fas |
| last_indexed | 2024-04-12T15:37:00Z |
| publishDate | 2019-08-01 |
| publisher | Kashan University of Medical Sciences and Health Services |
| record_format | Article |
| series | Fiyz̤ |
| spelling | doaj.art-bcceffb423d9463e860b92260fad652e2022-12-22T03:26:55ZfasKashan University of Medical Sciences and Health ServicesFiyz̤1029-78552008-98212019-08-01233241252Evaluation of antioxidant, anti-cancer and anti-inflammatory characteristics of bio-synthesized silver nanoparticles produced by waste extract of Rheum ribes L.Zahra Naeimi 0Ali Neamati 1Masoud Homayouni-Tabrizi 2Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, I. R. Iran.Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, I. R. Iran.Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, I. R. Iran.Background: This study was designed to evaluate the antioxidant, anti-inflammation and anti-cancer potency of silver nanoparticles produced by waste Rheum ribes L. extract. Materials and Methods: in this study, 10 gr of dried Rheum ribes L powder after 3 hours dissolving at 37°C was filtered and applied for silver nanoparticles preparation. Particle size, X-ray diffractometer (XRD), Fourier transform infrared radiometer (FT-IR) and transmission electron microscope (TEM) methods were used to measurement the properties of silver nanoparticles. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) method accompanied by 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) compounds were used to evaluate the cytotoxicity and antioxidant capacity of the nanoparticles. Results: The size of the produced silver nanoparticles was 28 nm with a uniform distribution and spherical appearance. The effective antioxidant dose for the ABTS and DPPH compounds was 200 µg/ml, and the obtained IC50 on HDF, Huvec, and MCF-7 cells for 24, 48 and 72 hours treatment were 30, 25, 12; 13.2, 11, 10; and 10, 9 and 8 µg/ml, respectively. Conclusion: The silver nanoparticles produced by waste Rheum ribes L. extract can have potential for use as a therapeutic strategy against cancer.http://feyz.kaums.ac.ir/article-1-3795-en.htmlRheum ribes LSilver nanoparticlesAntioxidantCancerAnti-inflammation |
| spellingShingle | Zahra Naeimi Ali Neamati Masoud Homayouni-Tabrizi Evaluation of antioxidant, anti-cancer and anti-inflammatory characteristics of bio-synthesized silver nanoparticles produced by waste extract of Rheum ribes L. Fiyz̤ Rheum ribes L Silver nanoparticles Antioxidant Cancer Anti-inflammation |
| title | Evaluation of antioxidant, anti-cancer and anti-inflammatory characteristics of bio-synthesized silver nanoparticles produced by waste extract of Rheum ribes L. |
| title_full | Evaluation of antioxidant, anti-cancer and anti-inflammatory characteristics of bio-synthesized silver nanoparticles produced by waste extract of Rheum ribes L. |
| title_fullStr | Evaluation of antioxidant, anti-cancer and anti-inflammatory characteristics of bio-synthesized silver nanoparticles produced by waste extract of Rheum ribes L. |
| title_full_unstemmed | Evaluation of antioxidant, anti-cancer and anti-inflammatory characteristics of bio-synthesized silver nanoparticles produced by waste extract of Rheum ribes L. |
| title_short | Evaluation of antioxidant, anti-cancer and anti-inflammatory characteristics of bio-synthesized silver nanoparticles produced by waste extract of Rheum ribes L. |
| title_sort | evaluation of antioxidant anti cancer and anti inflammatory characteristics of bio synthesized silver nanoparticles produced by waste extract of rheum ribes l |
| topic | Rheum ribes L Silver nanoparticles Antioxidant Cancer Anti-inflammation |
| url | http://feyz.kaums.ac.ir/article-1-3795-en.html |
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