Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling

Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling

In order to provide a sufficient number of cells for clinical use, mesenchymal stem cells (MSCs) must be cultured for long-term expansion, which inevitably triggers cellular senescence. Although the small size of MSCs is known as a critical determinant of their fate, the main regulators of stem cell...

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Bibliographic Details
Main Authors: Ji Hye Kwon, Miyeon Kim, Soyoun Um, Hyang Ju Lee, Yun Kyung Bae, Soo Jin Choi, Hyun Ho Hwang, Wonil Oh, Hye Jin Jin
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
small cell
mesenchymal stem cell senescence
senescence-associated secretory phenotype
growth-regulated oncogene-alpha
interukin-8
C-X-C motif chemokine receptor 2
Online Access:https://www.mdpi.com/2073-4409/10/1/63

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https://www.mdpi.com/2073-4409/10/1/63

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