Association Between Systemic Immune-Inflammation Index and Diabetic Depression
Jie Wang,1 Depu Zhou,1 Zhijuan Dai,2 Xiaokun Li1 1Department of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People’s Republic of China; 2Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-01-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/association-between-systemic-immune-inflammation-index-and-diabetic-de-peer-reviewed-article-CIA |
| _version_ | 1818858562860875776 |
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| author | Wang J Zhou D Dai Z Li X |
| author_facet | Wang J Zhou D Dai Z Li X |
| author_sort | Wang J |
| collection | DOAJ |
| description | Jie Wang,1 Depu Zhou,1 Zhijuan Dai,2 Xiaokun Li1 1Department of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People’s Republic of China; 2Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Xiaokun LiDepartment of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People’s Republic of ChinaEmail profxiaokunli@163.comBackground: Depression is highly prevalent in patients with diabetes mellitus (DM). Diabetic depression has been shown to be associated with low-grade systemic inflammation. In recent years, the systemic immune-inflammation (SII) index has been developed as an integrated and novel inflammatory indicator. The aims of this study were to investigate the relationship between diabetic depression and SII levels, adjusting for a wide range of potential confounding factors, to examine the potential of SII in predicting diabetic depression.Methods: The present cross-sectional study was conducted among adults with DM in the National Health and Nutrition Examination Survey between 2009 and 2016, the SII level was calculated as the platelet counts × neutrophil counts/lymphocyte counts. Patient Health Questionnaire‐9 was used to measure depression in patients with DM. Multivariable logistic regression and propensity score-matched analysis were used to analyze the association between SII levels and depression.Results: A total of 2566 patients with DM were included in the study, of which 370 (13.3%) were diagnosed with depression. Multivariable logistic regression showed that high SII level was an independent risk factor for diabetic depression (OR = 1.347, 95% CI: 1.031– 1.760, P = 0.02882) after adjusting for covariates. The relationship between SII and diabetic depression was further verified by propensity score-matched analysis.Conclusion: Our data suggest that SII is a risk factor for depression in patients with DM. The SII may be an easily accessible and cost-effective strategy for identifying depression in patients with DM. More studies are warranted to further analyze the role of SII in depression in diabetic patients.Keywords: systemic immune-inflammation index, depressive symptoms, diabetes mellitus, NHANES |
| first_indexed | 2024-12-19T08:58:16Z |
| format | Article |
| id | doaj.art-bcd173b117ea40c5b88380d27ed772e9 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-19T08:58:16Z |
| publishDate | 2021-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-bcd173b117ea40c5b88380d27ed772e92022-12-21T20:28:34ZengDove Medical PressClinical Interventions in Aging1178-19982021-01-01Volume 169710561058Association Between Systemic Immune-Inflammation Index and Diabetic DepressionWang JZhou DDai ZLi XJie Wang,1 Depu Zhou,1 Zhijuan Dai,2 Xiaokun Li1 1Department of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People’s Republic of China; 2Department of Endocrinology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Xiaokun LiDepartment of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People’s Republic of ChinaEmail profxiaokunli@163.comBackground: Depression is highly prevalent in patients with diabetes mellitus (DM). Diabetic depression has been shown to be associated with low-grade systemic inflammation. In recent years, the systemic immune-inflammation (SII) index has been developed as an integrated and novel inflammatory indicator. The aims of this study were to investigate the relationship between diabetic depression and SII levels, adjusting for a wide range of potential confounding factors, to examine the potential of SII in predicting diabetic depression.Methods: The present cross-sectional study was conducted among adults with DM in the National Health and Nutrition Examination Survey between 2009 and 2016, the SII level was calculated as the platelet counts × neutrophil counts/lymphocyte counts. Patient Health Questionnaire‐9 was used to measure depression in patients with DM. Multivariable logistic regression and propensity score-matched analysis were used to analyze the association between SII levels and depression.Results: A total of 2566 patients with DM were included in the study, of which 370 (13.3%) were diagnosed with depression. Multivariable logistic regression showed that high SII level was an independent risk factor for diabetic depression (OR = 1.347, 95% CI: 1.031– 1.760, P = 0.02882) after adjusting for covariates. The relationship between SII and diabetic depression was further verified by propensity score-matched analysis.Conclusion: Our data suggest that SII is a risk factor for depression in patients with DM. The SII may be an easily accessible and cost-effective strategy for identifying depression in patients with DM. More studies are warranted to further analyze the role of SII in depression in diabetic patients.Keywords: systemic immune-inflammation index, depressive symptoms, diabetes mellitus, NHANEShttps://www.dovepress.com/association-between-systemic-immune-inflammation-index-and-diabetic-de-peer-reviewed-article-CIAsystemic immune-inflammation indexdepressive symptomsdiabetes mellitusnhanes |
| spellingShingle | Wang J Zhou D Dai Z Li X Association Between Systemic Immune-Inflammation Index and Diabetic Depression Clinical Interventions in Aging systemic immune-inflammation index depressive symptoms diabetes mellitus nhanes |
| title | Association Between Systemic Immune-Inflammation Index and Diabetic Depression |
| title_full | Association Between Systemic Immune-Inflammation Index and Diabetic Depression |
| title_fullStr | Association Between Systemic Immune-Inflammation Index and Diabetic Depression |
| title_full_unstemmed | Association Between Systemic Immune-Inflammation Index and Diabetic Depression |
| title_short | Association Between Systemic Immune-Inflammation Index and Diabetic Depression |
| title_sort | association between systemic immune inflammation index and diabetic depression |
| topic | systemic immune-inflammation index depressive symptoms diabetes mellitus nhanes |
| url | https://www.dovepress.com/association-between-systemic-immune-inflammation-index-and-diabetic-de-peer-reviewed-article-CIA |
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