Therapeutic activity of lipoxin A4 in TiO2-induced arthritis in mice: NF-κB and Nrf2 in synovial fluid leukocytes and neuronal TRPV1 mechanisms

Therapeutic activity of lipoxin A4 in TiO2-induced arthritis in mice: NF-κB and Nrf2 in synovial fluid leukocytes and neuronal TRPV1 mechanisms

BackgroundLipoxin A4 (LXA4) has anti-inflammatory and pro-resolutive roles in inflammation. We evaluated the effects and mechanisms of action of LXA4 in titanium dioxide (TiO2) arthritis, a model of prosthesis-induced joint inflammation and pain.MethodsMice were stimulated with TiO2 (3mg) in the kne...

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Main Authors: Telma Saraiva-Santos, Tiago H. Zaninelli, Marília F. Manchope, Ketlem C. Andrade, Camila R. Ferraz, Mariana M. Bertozzi, Nayara A. Artero, Anelise Franciosi, Stephanie Badaro-Garcia, Larissa Staurengo-Ferrari, Sergio M. Borghi, Graziela S. Ceravolo, Avacir Casanova Andrello, Janaína Menezes Zanoveli, Michael S. Rogers, Rubia Casagrande, Felipe A. Pinho-Ribeiro, Waldiceu A. Verri
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
lipoxin A4
TiO2
ALX/FPR2
inflammation
TRPV1
ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.949407/full

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