CD4<sup>+</sup> T Cell-Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication through Autophagy

CD4<sup>+</sup> T Cell-Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication through Autophagy

ABSTRACT Therapeutic strategies that provide effective and broad‐spectrum neutralization against HIV-1 infection are highly desirable. Here, we investigate the potential of nanoengineered CD4+ T cell membrane-coated nanoparticles (TNP) to neutralize a broad range of HIV-1 strains. TNP displayed outs...

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Bibliographic Details
Main Authors: Gang Zhang, Grant R. Campbell, Qiangzhe Zhang, Erin Maule, Jonathan Hanna, Weiwei Gao, Liangfang Zhang, Stephen A. Spector
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mBio
Subjects:
HIV
nanoparticle
autophagy
neutralization
CD4+ T cell
macrophage
Online Access:https://journals.asm.org/doi/10.1128/mBio.00903-20

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