Hypergranular precursor B-cell acute lymphoblastic leukemia in a 16-year-old boy
Presence of cytoplasmic granules in the blasts is a well known feature of myeloid leukemia. ALL presenting with the numerous cytoplasmic granules in blasts is a rarity and may be misdiagnosed as acute myeloid leukemia. We describe a rare case of hypergranular precursor B-cell acute lymphoblastic leu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-07-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=3;spage=421;epage=423;aulast=Tembhare |
| _version_ | 1818412593731076096 |
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| author | Tembhare Prashant Subramanian P Sehgal Kunal Yajamanam Badrinath Kumar Ashok Gujral Sumeet |
| author_facet | Tembhare Prashant Subramanian P Sehgal Kunal Yajamanam Badrinath Kumar Ashok Gujral Sumeet |
| author_sort | Tembhare Prashant |
| collection | DOAJ |
| description | Presence of cytoplasmic granules in the blasts is a well known feature of myeloid leukemia. ALL presenting with the numerous cytoplasmic granules in blasts is a rarity and may be misdiagnosed as acute myeloid leukemia. We describe a rare case of hypergranular precursor B-cell acute lymphoblastic leukemia (ALL) in an adolescent male expressing CD10, CD19, CytoCD22, CD34, as well as CD13 and CD117. The blasts were cytochemically negative for myeloperoxidase (MPO), and acid phosphatase (ACP) but were positive for non-specific esterase (NSE). In centers where immunophenotypic panel is usually decided on the basis of morphology with limited antibodies may result in an erroneous typing of such rare diseases. Hence it is important to be aware of this rare entity and to confirm the lineage of acute leukemia by using a comprehensive panel of antibodies for immunophenotypic analysis. |
| first_indexed | 2024-12-14T10:49:47Z |
| format | Article |
| id | doaj.art-bcd20abd5f9b4711b6b9a90825503e46 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-14T10:49:47Z |
| publishDate | 2009-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-bcd20abd5f9b4711b6b9a90825503e462022-12-21T23:05:17ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292009-07-01523421423Hypergranular precursor B-cell acute lymphoblastic leukemia in a 16-year-old boyTembhare PrashantSubramanian PSehgal KunalYajamanam BadrinathKumar AshokGujral SumeetPresence of cytoplasmic granules in the blasts is a well known feature of myeloid leukemia. ALL presenting with the numerous cytoplasmic granules in blasts is a rarity and may be misdiagnosed as acute myeloid leukemia. We describe a rare case of hypergranular precursor B-cell acute lymphoblastic leukemia (ALL) in an adolescent male expressing CD10, CD19, CytoCD22, CD34, as well as CD13 and CD117. The blasts were cytochemically negative for myeloperoxidase (MPO), and acid phosphatase (ACP) but were positive for non-specific esterase (NSE). In centers where immunophenotypic panel is usually decided on the basis of morphology with limited antibodies may result in an erroneous typing of such rare diseases. Hence it is important to be aware of this rare entity and to confirm the lineage of acute leukemia by using a comprehensive panel of antibodies for immunophenotypic analysis.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=3;spage=421;epage=423;aulast=TembhareAcute lukemiahypergranular blastimmunophenotyping |
| spellingShingle | Tembhare Prashant Subramanian P Sehgal Kunal Yajamanam Badrinath Kumar Ashok Gujral Sumeet Hypergranular precursor B-cell acute lymphoblastic leukemia in a 16-year-old boy Indian Journal of Pathology and Microbiology Acute lukemia hypergranular blast immunophenotyping |
| title | Hypergranular precursor B-cell acute lymphoblastic leukemia in a 16-year-old boy |
| title_full | Hypergranular precursor B-cell acute lymphoblastic leukemia in a 16-year-old boy |
| title_fullStr | Hypergranular precursor B-cell acute lymphoblastic leukemia in a 16-year-old boy |
| title_full_unstemmed | Hypergranular precursor B-cell acute lymphoblastic leukemia in a 16-year-old boy |
| title_short | Hypergranular precursor B-cell acute lymphoblastic leukemia in a 16-year-old boy |
| title_sort | hypergranular precursor b cell acute lymphoblastic leukemia in a 16 year old boy |
| topic | Acute lukemia hypergranular blast immunophenotyping |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=3;spage=421;epage=423;aulast=Tembhare |
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