Sarcopenia is associated with mild-to-moderate chronic kidney disease in Chinese community-dwelling older men but not in women
Objective To determine whether a relationship exists between sarcopenia, including its individual components (muscle mass, muscle strength and gait speed), and mild-to-moderate chronic kidney disease (CKD) in Chinese older adults. Methods This cross-sectional study comprised participants aged ≥60 ye...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-11-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221136683 |
| _version_ | 1811210657159184384 |
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| author | Xiaoyu Chen Xiaoyan Zhu Peipei Han Yuanyuan Zhang Mian He Yuhui Zhang Jinghuan Liu Jiawei Tang Yisong Zhang Yaqing Zheng Ziwei Zhang Ming Li Qi Guo |
| author_facet | Xiaoyu Chen Xiaoyan Zhu Peipei Han Yuanyuan Zhang Mian He Yuhui Zhang Jinghuan Liu Jiawei Tang Yisong Zhang Yaqing Zheng Ziwei Zhang Ming Li Qi Guo |
| author_sort | Xiaoyu Chen |
| collection | DOAJ |
| description | Objective To determine whether a relationship exists between sarcopenia, including its individual components (muscle mass, muscle strength and gait speed), and mild-to-moderate chronic kidney disease (CKD) in Chinese older adults. Methods This cross-sectional study comprised participants aged ≥60 years from Tianjin and Shanghai, China, who joined a national free physical examination program between 2014 and 2019, and consented to study inclusion. Sarcopenia was defined according to the Asian Working Group for Sarcopenia (2019 version). Mild-to-moderate CKD was defined as estimated glomerular filtration rate (eGFR) between 45 ml/min/1.73 m 2 and 60 ml/min/1.73 m 2 . Results A total of 1627 participants were included (mean age, 69.32 ± 6.17 years; 43.8% male). Sarcopenia was significantly associated with mild-to-moderate CKD in men but not women. Among three physical performance components, slow gait speed (odds ratio 1.89, 95% confidence interval 1.38, 2.58) was associated with mild-to-moderate CKD in both men and women after adjusting for all other variables. Conclusions Sarcopenia was closely associated with mild-to-moderate CKD in older men, and slow gait speed was related to mild-to-moderate CKD in men and women. These findings may help guide better diagnosis and management of CKD in the context of slow gait speed, and facilitate earlier CKD detection and appropriate intervention in older adults. |
| first_indexed | 2024-04-12T04:59:30Z |
| format | Article |
| id | doaj.art-bcd446a03f614cac987185eeb333e76b |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-12T04:59:30Z |
| publishDate | 2022-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-bcd446a03f614cac987185eeb333e76b2022-12-22T03:47:02ZengSAGE PublishingJournal of International Medical Research1473-23002022-11-015010.1177/03000605221136683Sarcopenia is associated with mild-to-moderate chronic kidney disease in Chinese community-dwelling older men but not in womenXiaoyu ChenXiaoyan ZhuPeipei HanYuanyuan ZhangMian HeYuhui ZhangJinghuan LiuJiawei TangYisong ZhangYaqing ZhengZiwei ZhangMing LiQi GuoObjective To determine whether a relationship exists between sarcopenia, including its individual components (muscle mass, muscle strength and gait speed), and mild-to-moderate chronic kidney disease (CKD) in Chinese older adults. Methods This cross-sectional study comprised participants aged ≥60 years from Tianjin and Shanghai, China, who joined a national free physical examination program between 2014 and 2019, and consented to study inclusion. Sarcopenia was defined according to the Asian Working Group for Sarcopenia (2019 version). Mild-to-moderate CKD was defined as estimated glomerular filtration rate (eGFR) between 45 ml/min/1.73 m 2 and 60 ml/min/1.73 m 2 . Results A total of 1627 participants were included (mean age, 69.32 ± 6.17 years; 43.8% male). Sarcopenia was significantly associated with mild-to-moderate CKD in men but not women. Among three physical performance components, slow gait speed (odds ratio 1.89, 95% confidence interval 1.38, 2.58) was associated with mild-to-moderate CKD in both men and women after adjusting for all other variables. Conclusions Sarcopenia was closely associated with mild-to-moderate CKD in older men, and slow gait speed was related to mild-to-moderate CKD in men and women. These findings may help guide better diagnosis and management of CKD in the context of slow gait speed, and facilitate earlier CKD detection and appropriate intervention in older adults.https://doi.org/10.1177/03000605221136683 |
| spellingShingle | Xiaoyu Chen Xiaoyan Zhu Peipei Han Yuanyuan Zhang Mian He Yuhui Zhang Jinghuan Liu Jiawei Tang Yisong Zhang Yaqing Zheng Ziwei Zhang Ming Li Qi Guo Sarcopenia is associated with mild-to-moderate chronic kidney disease in Chinese community-dwelling older men but not in women Journal of International Medical Research |
| title | Sarcopenia is associated with mild-to-moderate chronic kidney disease in Chinese community-dwelling older men but not in women |
| title_full | Sarcopenia is associated with mild-to-moderate chronic kidney disease in Chinese community-dwelling older men but not in women |
| title_fullStr | Sarcopenia is associated with mild-to-moderate chronic kidney disease in Chinese community-dwelling older men but not in women |
| title_full_unstemmed | Sarcopenia is associated with mild-to-moderate chronic kidney disease in Chinese community-dwelling older men but not in women |
| title_short | Sarcopenia is associated with mild-to-moderate chronic kidney disease in Chinese community-dwelling older men but not in women |
| title_sort | sarcopenia is associated with mild to moderate chronic kidney disease in chinese community dwelling older men but not in women |
| url | https://doi.org/10.1177/03000605221136683 |
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