Anticancer Activity of Novel Difluorinated Curcumin Analog and Its Inclusion Complex with 2-Hydroxypropyl-β-Cyclodextrin against Pancreatic Cancer

Anticancer Activity of Novel Difluorinated Curcumin Analog and Its Inclusion Complex with 2-Hydroxypropyl-β-Cyclodextrin against Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is the primary reason for cancer-related deaths in the US. Genetic mutations, drug resistance, the involvement of multiple signaling pathways, cancer stem cells (CSCs), and desmoplastic stroma, which hinders drug penetrance, contribute to poor chemotherapeutic...

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Bibliographic Details
Main Authors: Sangita Bhattacharyya, Hindole Ghosh, Obdulia Covarrubias-Zambrano, Krishan Jain, K. Venkateswara Swamy, Anup Kasi, Ameer Hamza, Shrikant Anant, Michael VanSaun, Scott J. Weir, Stefan H. Bossmann, Subhash B. Padhye, Prasad Dandawate
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
curcumin
difluorinated curcumin
CDF
pancreatic cancer
PDAC
2-hydroxypropyl-β-cyclodextrin
Online Access:https://www.mdpi.com/1422-0067/24/7/6336

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