Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties
Abstract Antimicrobial peptides have attracted attention as alternatives to conventional antibiotics. Previously, a novel antimicrobial peptide, melectin, consisting of 18 amino acids was isolated from the venom of a bee, Melecta albifrons. Here, we investigated the antibacterial activity of melecti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-66995-7 |
| _version_ | 1818722893031276544 |
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| author | Su Jin Ko Eunji Park Alina Asandei Jee-Young Choi Seung-Chul Lee Chang Ho Seo Tudor Luchian Yoonkyung Park |
| author_facet | Su Jin Ko Eunji Park Alina Asandei Jee-Young Choi Seung-Chul Lee Chang Ho Seo Tudor Luchian Yoonkyung Park |
| author_sort | Su Jin Ko |
| collection | DOAJ |
| description | Abstract Antimicrobial peptides have attracted attention as alternatives to conventional antibiotics. Previously, a novel antimicrobial peptide, melectin, consisting of 18 amino acids was isolated from the venom of a bee, Melecta albifrons. Here, we investigated the antibacterial activity of melectin against drug-resistant bacteria. Melectin showed broad-spectrum antimicrobial activity but low cytotoxicity and no hemolytic activity. Melectin maintained its antimicrobial activity at physiological salt concentrations. Melectin is an α-helical structure that binds to the bacterial membrane via electrostatic interactions and kills bacteria in a short time by bacterial membrane targeting. Collectively, our results suggest that melectin has antibacterial activity and anti-inflammatory activity. |
| first_indexed | 2024-12-17T21:01:51Z |
| format | Article |
| id | doaj.art-bcd81e0dfe3d49aa8b83f3167750b21b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T21:01:51Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bcd81e0dfe3d49aa8b83f3167750b21b2022-12-21T21:32:43ZengNature PortfolioScientific Reports2045-23222020-06-0110111210.1038/s41598-020-66995-7Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant propertiesSu Jin Ko0Eunji Park1Alina Asandei2Jee-Young Choi3Seung-Chul Lee4Chang Ho Seo5Tudor Luchian6Yoonkyung Park7Department of Biomedical Science, Chosun UniversityDepartment of Biomedical Science, Chosun UniversityInterdisciplinary Research Institute, Sciences Department, Alexandru I. Cuza UniversityChonnam National University HospitalDepartments of Dermatology, Chonnam National University Medical SchoolDepartment of Bioinformatics, Kongju National UniversityDepartment of Physics, Alexandru I. Cuza UniversityDepartment of Biomedical Science, Chosun UniversityAbstract Antimicrobial peptides have attracted attention as alternatives to conventional antibiotics. Previously, a novel antimicrobial peptide, melectin, consisting of 18 amino acids was isolated from the venom of a bee, Melecta albifrons. Here, we investigated the antibacterial activity of melectin against drug-resistant bacteria. Melectin showed broad-spectrum antimicrobial activity but low cytotoxicity and no hemolytic activity. Melectin maintained its antimicrobial activity at physiological salt concentrations. Melectin is an α-helical structure that binds to the bacterial membrane via electrostatic interactions and kills bacteria in a short time by bacterial membrane targeting. Collectively, our results suggest that melectin has antibacterial activity and anti-inflammatory activity.https://doi.org/10.1038/s41598-020-66995-7 |
| spellingShingle | Su Jin Ko Eunji Park Alina Asandei Jee-Young Choi Seung-Chul Lee Chang Ho Seo Tudor Luchian Yoonkyung Park Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties Scientific Reports |
| title | Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties |
| title_full | Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties |
| title_fullStr | Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties |
| title_full_unstemmed | Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties |
| title_short | Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties |
| title_sort | bee venom derived antimicrobial peptide melectin has broad spectrum potency cell selectivity and salt resistant properties |
| url | https://doi.org/10.1038/s41598-020-66995-7 |
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