Bivalirudin resistance during heart transplantation surgery.
Introduction: : Direct thrombin inhibitors are drugs of choice used to prevent thrombotic complications in hospitalized patients after heparin induced thrombocytopenia (HIT) diagnosis. Material and method: : We present a case of bivalirudin resistance in patient undergoing heart transplantation due...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Transplantation Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451959620300330 |
| _version_ | 1818844977581522944 |
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| author | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Marcin Ligowski Ewa Goszczyńska Marek Jemielity |
| author_facet | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Marcin Ligowski Ewa Goszczyńska Marek Jemielity |
| author_sort | Tomasz Urbanowicz |
| collection | DOAJ |
| description | Introduction: : Direct thrombin inhibitors are drugs of choice used to prevent thrombotic complications in hospitalized patients after heparin induced thrombocytopenia (HIT) diagnosis. Material and method: : We present a case of bivalirudin resistance in patient undergoing heart transplantation due to dilated cardiomyopathy with confirmation of HIT. Bivalirudin was given intraoperatively as cardiopulmonary bypass circulation was applied. From initial infusion rate of 2.5 mg/kg/hour, up to 4 mg/kg/hour, due to low ACT results. The repeated ACT results were 422s, 452s and 468s on 5 minutes intervals. Conclusion: : Resistance to bivalirudin, though rare, can be overbeared by high bivalirudin dosing under ACT control during surgical procedures including heart transplantation. |
| first_indexed | 2024-12-19T05:22:20Z |
| format | Article |
| id | doaj.art-bcd9d16d0c104a20abfe5bccfacfb720 |
| institution | Directory Open Access Journal |
| issn | 2451-9596 |
| language | English |
| last_indexed | 2024-12-19T05:22:20Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Transplantation Reports |
| spelling | doaj.art-bcd9d16d0c104a20abfe5bccfacfb7202022-12-21T20:34:28ZengElsevierTransplantation Reports2451-95962021-03-0161100072Bivalirudin resistance during heart transplantation surgery.Tomasz Urbanowicz0Anna Olasińska-Wiśniewska1Marcin Ligowski2Ewa Goszczyńska3Marek Jemielity4Corresponding author: Tomasz Urbanowicz MD, PhD, Holy Saint Transfiguration Hospital, Poznan University of Medical Sciences, ½ Długa Street, Poznań, Poland; Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznań, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznań, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznań, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznań, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznań, PolandIntroduction: : Direct thrombin inhibitors are drugs of choice used to prevent thrombotic complications in hospitalized patients after heparin induced thrombocytopenia (HIT) diagnosis. Material and method: : We present a case of bivalirudin resistance in patient undergoing heart transplantation due to dilated cardiomyopathy with confirmation of HIT. Bivalirudin was given intraoperatively as cardiopulmonary bypass circulation was applied. From initial infusion rate of 2.5 mg/kg/hour, up to 4 mg/kg/hour, due to low ACT results. The repeated ACT results were 422s, 452s and 468s on 5 minutes intervals. Conclusion: : Resistance to bivalirudin, though rare, can be overbeared by high bivalirudin dosing under ACT control during surgical procedures including heart transplantation.http://www.sciencedirect.com/science/article/pii/S2451959620300330BivalirudinHITHeart transplantationBivalirudin resistanceACT |
| spellingShingle | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Marcin Ligowski Ewa Goszczyńska Marek Jemielity Bivalirudin resistance during heart transplantation surgery. Transplantation Reports Bivalirudin HIT Heart transplantation Bivalirudin resistance ACT |
| title | Bivalirudin resistance during heart transplantation surgery. |
| title_full | Bivalirudin resistance during heart transplantation surgery. |
| title_fullStr | Bivalirudin resistance during heart transplantation surgery. |
| title_full_unstemmed | Bivalirudin resistance during heart transplantation surgery. |
| title_short | Bivalirudin resistance during heart transplantation surgery. |
| title_sort | bivalirudin resistance during heart transplantation surgery |
| topic | Bivalirudin HIT Heart transplantation Bivalirudin resistance ACT |
| url | http://www.sciencedirect.com/science/article/pii/S2451959620300330 |
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