Expanding catalytic promiscuity of a bifunctional terpene synthase through a single mutation-induced change in hydrogen-bond network within the catalytic pocket

Expanding catalytic promiscuity of a bifunctional terpene synthase through a single mutation-induced change in hydrogen-bond network within the catalytic pocket

Fungal bifunctional terpene synthases (BFTSs) catalyze the formation of numerous di-/sester-/tri-terpenes skeletons. However, the mechanism in controlling the cyclization pattern of terpene scaffolds is rarely deciphered for further application of tuning the catalytic promiscuity of terpene synthase...

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Bibliographic Details
Main Authors: Xinye Wang, Yiyi Huang, Weiyan Zhang, Kangjie Lv, Xiaoying Li, Zhixin Wang, Li Zhang, Tom Hsiang, Lixin Zhang, Liming Ouyang, Xueting Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-06-01
Series:Synthetic and Systems Biotechnology
Subjects:
Bifunctional terpene synthase
Sesterterpene
Carbocation transportation
Density functional theory calculations
Molecular dynamics simulations
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X24000413

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