THE PROGNOSTIC MODEL OF ANTITUMOR EFFECT OF TARGETED DRUGS IN IMMUNOTHERAPY
A prognostic model for constructing hypotheses about the relationship of combinations of cytokines with the proliferative activity of cancer cells is proposed. The model is based on the use of inductive inference methods. The methodology takes into account the synergistic interaction of cytokines an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2016-08-01
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| Series: | Тонкие химические технологии |
| Subjects: | |
| Online Access: | https://www.finechem-mirea.ru/jour/article/view/42 |
| _version_ | 1797882064401334272 |
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| author | V. V. Burlyaev А. А. Davydenko O. M. Nikolaeva L. I. Russu I. A. Suetina M. V. Mezentseva |
| author_facet | V. V. Burlyaev А. А. Davydenko O. M. Nikolaeva L. I. Russu I. A. Suetina M. V. Mezentseva |
| author_sort | V. V. Burlyaev |
| collection | DOAJ |
| description | A prognostic model for constructing hypotheses about the relationship of combinations of cytokines with the proliferative activity of cancer cells is proposed. The model is based on the use of inductive inference methods. The methodology takes into account the synergistic interaction of cytokines and uses sequential construction of logical formulas for selecting groups of cytokines, a statistical analysis of contingency tables and logical integration of the obtained estimates. Implementation of the proposed method in the information system of forecasting the effect of targeted anticancer drugs in immunotherapy will greatly accelerate research in this area. |
| first_indexed | 2024-04-10T03:29:00Z |
| format | Article |
| id | doaj.art-bcdc2f4a3d8d46f7b406b37543d6c8ce |
| institution | Directory Open Access Journal |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| last_indexed | 2024-04-10T03:29:00Z |
| publishDate | 2016-08-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj.art-bcdc2f4a3d8d46f7b406b37543d6c8ce2023-03-13T07:25:37ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752016-08-01114697410.32362/2410-6593-2016-11-4-69-7442THE PROGNOSTIC MODEL OF ANTITUMOR EFFECT OF TARGETED DRUGS IN IMMUNOTHERAPYV. V. Burlyaev0А. А. Davydenko1O. M. Nikolaeva2L. I. Russu3I. A. Suetina4M. V. Mezentseva5Moscow Technological University (Institute of Fine Chemical Technologies)Moscow Technological University (Institute of Fine Chemical Technologies)Moscow Technological University (Institute of Fine Chemical Technologies)Gamaleya Federal Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian FederationGamaleya Federal Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian FederationGamaleya Federal Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian FederationA prognostic model for constructing hypotheses about the relationship of combinations of cytokines with the proliferative activity of cancer cells is proposed. The model is based on the use of inductive inference methods. The methodology takes into account the synergistic interaction of cytokines and uses sequential construction of logical formulas for selecting groups of cytokines, a statistical analysis of contingency tables and logical integration of the obtained estimates. Implementation of the proposed method in the information system of forecasting the effect of targeted anticancer drugs in immunotherapy will greatly accelerate research in this area.https://www.finechem-mirea.ru/jour/article/view/42combination of cytokinesinformation systemcontingency tabletargeted drugsimmunotherapycancer cell |
| spellingShingle | V. V. Burlyaev А. А. Davydenko O. M. Nikolaeva L. I. Russu I. A. Suetina M. V. Mezentseva THE PROGNOSTIC MODEL OF ANTITUMOR EFFECT OF TARGETED DRUGS IN IMMUNOTHERAPY Тонкие химические технологии combination of cytokines information system contingency table targeted drugs immunotherapy cancer cell |
| title | THE PROGNOSTIC MODEL OF ANTITUMOR EFFECT OF TARGETED DRUGS IN IMMUNOTHERAPY |
| title_full | THE PROGNOSTIC MODEL OF ANTITUMOR EFFECT OF TARGETED DRUGS IN IMMUNOTHERAPY |
| title_fullStr | THE PROGNOSTIC MODEL OF ANTITUMOR EFFECT OF TARGETED DRUGS IN IMMUNOTHERAPY |
| title_full_unstemmed | THE PROGNOSTIC MODEL OF ANTITUMOR EFFECT OF TARGETED DRUGS IN IMMUNOTHERAPY |
| title_short | THE PROGNOSTIC MODEL OF ANTITUMOR EFFECT OF TARGETED DRUGS IN IMMUNOTHERAPY |
| title_sort | prognostic model of antitumor effect of targeted drugs in immunotherapy |
| topic | combination of cytokines information system contingency table targeted drugs immunotherapy cancer cell |
| url | https://www.finechem-mirea.ru/jour/article/view/42 |
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