Macrophage Biology in Human Granulomatous Skin Inflammation
Cutaneous granulomatoses represent a heterogeneous group of diseases, which are defined by macrophage infiltration in the skin. Skin granuloma can be formed in the context of infectious and non-infectious conditions. Recent technological advances have deepened our understanding of the pathophysiolog...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/5/4624 |
| _version_ | 1797615194021560320 |
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| author | Henning Klapproth Manuel Huerta Arana Mario Fabri |
| author_facet | Henning Klapproth Manuel Huerta Arana Mario Fabri |
| author_sort | Henning Klapproth |
| collection | DOAJ |
| description | Cutaneous granulomatoses represent a heterogeneous group of diseases, which are defined by macrophage infiltration in the skin. Skin granuloma can be formed in the context of infectious and non-infectious conditions. Recent technological advances have deepened our understanding of the pathophysiology of granulomatous skin inflammation, and they provide novel insights into human tissue macrophage biology at the site of ongoing disease. Here, we discuss findings on macrophage immune function and metabolism derived from three prototypic cutaneous granulomatoses: granuloma annulare, sarcoidosis, and leprosy. |
| first_indexed | 2024-03-11T07:22:55Z |
| format | Article |
| id | doaj.art-bcdd4efe4da7434f83d10aac29377786 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:22:55Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bcdd4efe4da7434f83d10aac293777862023-11-17T07:51:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01245462410.3390/ijms24054624Macrophage Biology in Human Granulomatous Skin InflammationHenning Klapproth0Manuel Huerta Arana1Mario Fabri2Department of Dermatology and Venereology, Faculty of Medicine, University of Cologne, and University Hospital of Cologne, 50937 Cologne, GermanyDepartment of Dermatology and Venereology, Faculty of Medicine, University of Cologne, and University Hospital of Cologne, 50937 Cologne, GermanyDepartment of Dermatology and Venereology, Faculty of Medicine, University of Cologne, and University Hospital of Cologne, 50937 Cologne, GermanyCutaneous granulomatoses represent a heterogeneous group of diseases, which are defined by macrophage infiltration in the skin. Skin granuloma can be formed in the context of infectious and non-infectious conditions. Recent technological advances have deepened our understanding of the pathophysiology of granulomatous skin inflammation, and they provide novel insights into human tissue macrophage biology at the site of ongoing disease. Here, we discuss findings on macrophage immune function and metabolism derived from three prototypic cutaneous granulomatoses: granuloma annulare, sarcoidosis, and leprosy.https://www.mdpi.com/1422-0067/24/5/4624granulomamacrophagemetabolisminterferon-γimmune functiongranuloma annulare |
| spellingShingle | Henning Klapproth Manuel Huerta Arana Mario Fabri Macrophage Biology in Human Granulomatous Skin Inflammation International Journal of Molecular Sciences granuloma macrophage metabolism interferon-γ immune function granuloma annulare |
| title | Macrophage Biology in Human Granulomatous Skin Inflammation |
| title_full | Macrophage Biology in Human Granulomatous Skin Inflammation |
| title_fullStr | Macrophage Biology in Human Granulomatous Skin Inflammation |
| title_full_unstemmed | Macrophage Biology in Human Granulomatous Skin Inflammation |
| title_short | Macrophage Biology in Human Granulomatous Skin Inflammation |
| title_sort | macrophage biology in human granulomatous skin inflammation |
| topic | granuloma macrophage metabolism interferon-γ immune function granuloma annulare |
| url | https://www.mdpi.com/1422-0067/24/5/4624 |
| work_keys_str_mv | AT henningklapproth macrophagebiologyinhumangranulomatousskininflammation AT manuelhuertaarana macrophagebiologyinhumangranulomatousskininflammation AT mariofabri macrophagebiologyinhumangranulomatousskininflammation |