Seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with HIV positive from Ebonyi State, Nigeria: a cross-sectional study
Objectives To assess the seroprevalence of herpes simplex virus (HSV) types 1 and 2 in patients infected with HIV in Nigeria.Design Cross-sectional design from January to June 2019.Setting Federal Teaching Hospital, Ebonyi State, Nigeria.Participants A total of 276 patients with HIV were analysed us...
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| Format: | Article |
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BMJ Publishing Group
2023-04-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/4/e069339.full |
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| author | Euslar Nnenna Onu Uchechukwu Onyeukwu Ekuma Hawraa K Judi Ogbonnaya Ogbu Nworie Okoro Gloria C Ajugwo Sousan Akrami Chukwudum S Okoli Chioma Ngozi Anyanwu Morteza Saki Peter Anyigor Edeh |
| author_facet | Euslar Nnenna Onu Uchechukwu Onyeukwu Ekuma Hawraa K Judi Ogbonnaya Ogbu Nworie Okoro Gloria C Ajugwo Sousan Akrami Chukwudum S Okoli Chioma Ngozi Anyanwu Morteza Saki Peter Anyigor Edeh |
| author_sort | Euslar Nnenna Onu |
| collection | DOAJ |
| description | Objectives To assess the seroprevalence of herpes simplex virus (HSV) types 1 and 2 in patients infected with HIV in Nigeria.Design Cross-sectional design from January to June 2019.Setting Federal Teaching Hospital, Ebonyi State, Nigeria.Participants A total of 276 patients with HIV were analysed using ELISA method for the presence of HSV-1 and HSV-2 specific IgG antibodies.Outcomes Fisher’s exact test was used to determine the association between the seroprevalence of HSV and demographic variables (statistically significant=p value ≤0.05).Results Totally, 212 (76.8%) and 155 (56.2%) patients with HIV were seropositive for HSV-1 and HSV-2 IgG antibodies, respectively. The seroprevalence of HSV-1 was significantly higher than the HSV-2 in patients with HIV (p value <0.0001). HSV-1 and HSV-2 seroprevalence were higher in patients aged more than 30 years. The seroprevalence of HSV-1 was significantly higher (p=0.01) in females (82.4%, 131/159) than males (69.2%, 81/117), but there was no significant difference in seroprevalence of HSV-2 in females (57.9%, 92/159) compared with males (53.8%, 63/117) (p=0.51). Professional drivers had a higher seroprevalence of HSV-1 and HSV-2 and there was a significant association between the occupation and the HSV-1 and HSV-2 seropositivity (p>0.05). The seroprevalence of HSV-1 was significantly higher in the singles (87.4%, 90/103) than the married patients with HIV (p=0.001). However, HSV-2 seroprevalence was significantly higher in the married patients with HIV (63.6%, 110/173) (p=0.001).Conclusions Prevalence of 76.8% for HSV-1 and 56.2% for HSV-2 among patients with HIV was seen. The HSV-1 was significantly higher in the singles while HSV-2 seroprevalence was significantly higher in the married patients with HIV with HSV-1 and HSV-2 coinfection rate of 7.6%. This study became very imperative to provide an important insight into the hidden dynamics of HSV infections. |
| first_indexed | 2024-04-09T17:17:37Z |
| format | Article |
| id | doaj.art-bcde03fd6e4e41259eca2e11ccb96174 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2025-02-18T07:14:36Z |
| publishDate | 2023-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-bcde03fd6e4e41259eca2e11ccb961742024-11-08T03:40:08ZengBMJ Publishing GroupBMJ Open2044-60552023-04-0113410.1136/bmjopen-2022-069339Seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with HIV positive from Ebonyi State, Nigeria: a cross-sectional studyEuslar Nnenna Onu0Uchechukwu Onyeukwu Ekuma1Hawraa K Judi2Ogbonnaya Ogbu3Nworie Okoro4Gloria C Ajugwo5Sousan Akrami6Chukwudum S Okoli7Chioma Ngozi Anyanwu8Morteza Saki9Peter Anyigor Edeh10Ebonyi State School of Health Technology, Ngbo, Ebonyi, NigeriaDepartment of Microbiology, Federal University of Technology, Owerri, Imo State, NigeriaDepartment of Medical Physics, Hilla University College, Babylon, IraqDepartment of Applied Microbiology, Ebonyi State University, Abakaliki, NigeriaDepartment of Biological Sciences, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, Ebonyi State, NigeriaDepartment of Microbiology, Federal University of Technology, Owerri, Imo State, NigeriaDepartment of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Applied Microbiology, Nnamdi Azikiwe University, Awka, Anambra State, NigeriaDepartment of Microbiology/Biochemistry, Federal Polytechnic Nekede, Imo State, NigeriaDepartment of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, NigeriaObjectives To assess the seroprevalence of herpes simplex virus (HSV) types 1 and 2 in patients infected with HIV in Nigeria.Design Cross-sectional design from January to June 2019.Setting Federal Teaching Hospital, Ebonyi State, Nigeria.Participants A total of 276 patients with HIV were analysed using ELISA method for the presence of HSV-1 and HSV-2 specific IgG antibodies.Outcomes Fisher’s exact test was used to determine the association between the seroprevalence of HSV and demographic variables (statistically significant=p value ≤0.05).Results Totally, 212 (76.8%) and 155 (56.2%) patients with HIV were seropositive for HSV-1 and HSV-2 IgG antibodies, respectively. The seroprevalence of HSV-1 was significantly higher than the HSV-2 in patients with HIV (p value <0.0001). HSV-1 and HSV-2 seroprevalence were higher in patients aged more than 30 years. The seroprevalence of HSV-1 was significantly higher (p=0.01) in females (82.4%, 131/159) than males (69.2%, 81/117), but there was no significant difference in seroprevalence of HSV-2 in females (57.9%, 92/159) compared with males (53.8%, 63/117) (p=0.51). Professional drivers had a higher seroprevalence of HSV-1 and HSV-2 and there was a significant association between the occupation and the HSV-1 and HSV-2 seropositivity (p>0.05). The seroprevalence of HSV-1 was significantly higher in the singles (87.4%, 90/103) than the married patients with HIV (p=0.001). However, HSV-2 seroprevalence was significantly higher in the married patients with HIV (63.6%, 110/173) (p=0.001).Conclusions Prevalence of 76.8% for HSV-1 and 56.2% for HSV-2 among patients with HIV was seen. The HSV-1 was significantly higher in the singles while HSV-2 seroprevalence was significantly higher in the married patients with HIV with HSV-1 and HSV-2 coinfection rate of 7.6%. This study became very imperative to provide an important insight into the hidden dynamics of HSV infections.https://bmjopen.bmj.com/content/13/4/e069339.full |
| spellingShingle | Euslar Nnenna Onu Uchechukwu Onyeukwu Ekuma Hawraa K Judi Ogbonnaya Ogbu Nworie Okoro Gloria C Ajugwo Sousan Akrami Chukwudum S Okoli Chioma Ngozi Anyanwu Morteza Saki Peter Anyigor Edeh Seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with HIV positive from Ebonyi State, Nigeria: a cross-sectional study BMJ Open |
| title | Seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with HIV positive from Ebonyi State, Nigeria: a cross-sectional study |
| title_full | Seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with HIV positive from Ebonyi State, Nigeria: a cross-sectional study |
| title_fullStr | Seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with HIV positive from Ebonyi State, Nigeria: a cross-sectional study |
| title_full_unstemmed | Seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with HIV positive from Ebonyi State, Nigeria: a cross-sectional study |
| title_short | Seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with HIV positive from Ebonyi State, Nigeria: a cross-sectional study |
| title_sort | seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with hiv positive from ebonyi state nigeria a cross sectional study |
| url | https://bmjopen.bmj.com/content/13/4/e069339.full |
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