Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis

Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF), a chronic disease of unknown cause, is characterized by abnormal accumulation of extracellular matrix (ECM) in fibrotic foci in the lung. Previous studies have shown that the transforming growth factor β1 (TGFβ1) and signal transducers and activators of transcrip...

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Bibliographic Details
Main Authors: Dae-Geun Song, Doyeun Kim, Jae Woo Jung, Seo Hee Nam, Ji Eon Kim, Hye-Jin Kim, Jong Hyun Kim, Cheol-Ho Pan, Sunghoon Kim, Jung Weon Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
idiopathic pulmonary fibrosis
bleomycin fibrotic animal model
extracellular matrix
prolyl-tRNA-synthetase
signal transduction
STAT6
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01337/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.01337/full

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