Total antioxidant blood capacity in patients with type 2 diabetes mellitus and distal symmetrical polyneuropathy
Background/Aim. Reduced systemic antioxidant defense is considered to play an important mediating role in pathogenesis of diabetic neuropathy. The aim of this study was to evaluate if the total antioxidant blood capacity (TAC) is reduced in patients with type 2 diabetes mellitus (DM) and diabetic di...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2008-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500809663D.pdf |
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| author | Đorđević Gordana Đurić Stojanka Apostolski Slobodan Đorđević Vidosava Živković Miroslava |
| author_facet | Đorđević Gordana Đurić Stojanka Apostolski Slobodan Đorđević Vidosava Živković Miroslava |
| author_sort | Đorđević Gordana |
| collection | DOAJ |
| description | Background/Aim. Reduced systemic antioxidant defense is considered to play an important mediating role in pathogenesis of diabetic neuropathy. The aim of this study was to evaluate if the total antioxidant blood capacity (TAC) is reduced in patients with type 2 diabetes mellitus (DM) and diabetic distal symmetrical polyneuropathy (DDSP) and to correlate this antioxidant capacity with the degree of peripheral nerve dysfunction. Methods. This study involved 100 patients with type 2 DM and signs of DDSP, as well as the control group of 50 healthy subjects. The evaluation of DDSP was based on physical examination and nerve conduction studies. The degree of peripheral nerve dysfunction was estimated by scoring and analysing sensory and motor nerve conduction parameters (distal latency and amplitude of evoked potential, conduction velocity). Laboratory analyses involved blood glucose and HbA1C levels, as well as plasma TAC. Results. Blood glucose and HbA1C level was significantly higher in the patients than in the control group (p < 0.0001). The TAC was depleted in the diabetic group and the depletion was statistically significant (p < 0.0001). There was no significant correlation between the TAC and the serum glucose level, TAC and HbA1C level as well as between TAC and the duration of DM. There was no significant correlation between TAC and peripheral nerve conduction parameters. Conclusion. Total antioxidant blood capacity is reduced in patients with DDSP, but it does not correlate with blood sugar level, with the duration of DM or with the degree of functional nerve damage. These results show a reduced systemic antioxidant defence in patients with type 2 DM and DDSP. However, it is still unclear to what extent the oxidative stress is a contributing factor or leading cause of diabetic neuropathy, suggesting that further studies are necessary. |
| first_indexed | 2024-12-20T10:17:06Z |
| format | Article |
| id | doaj.art-bce2cea0f55c4c729b54804ab9e04169 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-20T10:17:06Z |
| publishDate | 2008-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-bce2cea0f55c4c729b54804ab9e041692022-12-21T19:44:02ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502008-01-0165966366910.2298/VSP0809663DTotal antioxidant blood capacity in patients with type 2 diabetes mellitus and distal symmetrical polyneuropathyĐorđević GordanaĐurić StojankaApostolski SlobodanĐorđević VidosavaŽivković MiroslavaBackground/Aim. Reduced systemic antioxidant defense is considered to play an important mediating role in pathogenesis of diabetic neuropathy. The aim of this study was to evaluate if the total antioxidant blood capacity (TAC) is reduced in patients with type 2 diabetes mellitus (DM) and diabetic distal symmetrical polyneuropathy (DDSP) and to correlate this antioxidant capacity with the degree of peripheral nerve dysfunction. Methods. This study involved 100 patients with type 2 DM and signs of DDSP, as well as the control group of 50 healthy subjects. The evaluation of DDSP was based on physical examination and nerve conduction studies. The degree of peripheral nerve dysfunction was estimated by scoring and analysing sensory and motor nerve conduction parameters (distal latency and amplitude of evoked potential, conduction velocity). Laboratory analyses involved blood glucose and HbA1C levels, as well as plasma TAC. Results. Blood glucose and HbA1C level was significantly higher in the patients than in the control group (p < 0.0001). The TAC was depleted in the diabetic group and the depletion was statistically significant (p < 0.0001). There was no significant correlation between the TAC and the serum glucose level, TAC and HbA1C level as well as between TAC and the duration of DM. There was no significant correlation between TAC and peripheral nerve conduction parameters. Conclusion. Total antioxidant blood capacity is reduced in patients with DDSP, but it does not correlate with blood sugar level, with the duration of DM or with the degree of functional nerve damage. These results show a reduced systemic antioxidant defence in patients with type 2 DM and DDSP. However, it is still unclear to what extent the oxidative stress is a contributing factor or leading cause of diabetic neuropathy, suggesting that further studies are necessary.http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500809663D.pdfdiabetes mellitusdiabetic neuropathiesoxidativestress |
| spellingShingle | Đorđević Gordana Đurić Stojanka Apostolski Slobodan Đorđević Vidosava Živković Miroslava Total antioxidant blood capacity in patients with type 2 diabetes mellitus and distal symmetrical polyneuropathy Vojnosanitetski Pregled diabetes mellitus diabetic neuropathies oxidativestress |
| title | Total antioxidant blood capacity in patients with type 2 diabetes mellitus and distal symmetrical polyneuropathy |
| title_full | Total antioxidant blood capacity in patients with type 2 diabetes mellitus and distal symmetrical polyneuropathy |
| title_fullStr | Total antioxidant blood capacity in patients with type 2 diabetes mellitus and distal symmetrical polyneuropathy |
| title_full_unstemmed | Total antioxidant blood capacity in patients with type 2 diabetes mellitus and distal symmetrical polyneuropathy |
| title_short | Total antioxidant blood capacity in patients with type 2 diabetes mellitus and distal symmetrical polyneuropathy |
| title_sort | total antioxidant blood capacity in patients with type 2 diabetes mellitus and distal symmetrical polyneuropathy |
| topic | diabetes mellitus diabetic neuropathies oxidativestress |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500809663D.pdf |
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