Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing
Abstract Serious infection caused by drug-resistant gram-negative bacteria and their secreted toxins (e.g., lipopolysaccharide) is a serious threat to human health. Thus, treatment strategies that efficiently kill bacteria and reducing the impact of their toxins simultaneously are urgently required....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-01130-w |
| _version_ | 1811280077135020032 |
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| author | Zaihui Peng Xiaochun Zhang Long Yuan Ting Li Yajie Chen Hao Tian Dandan Ma Jun Deng Xiaowei Qi Xuntao Yin |
| author_facet | Zaihui Peng Xiaochun Zhang Long Yuan Ting Li Yajie Chen Hao Tian Dandan Ma Jun Deng Xiaowei Qi Xuntao Yin |
| author_sort | Zaihui Peng |
| collection | DOAJ |
| description | Abstract Serious infection caused by drug-resistant gram-negative bacteria and their secreted toxins (e.g., lipopolysaccharide) is a serious threat to human health. Thus, treatment strategies that efficiently kill bacteria and reducing the impact of their toxins simultaneously are urgently required. Herein, a novel antibacterial platform composed of a mesoporous copper silicate microsphere (CSO) core and a platelet membrane (PM) shell was prepared (CSO@PM). CSO@PM specifically targets bacteria owing to formyl peptide receptors on the PM and, combined with photothermal therapy (PTT), exhibits highly effective bacter icidal activity. Importantly, CSO@PM can adsorb lipopolysaccharide secreted by gram-negative bacteria, resulting in inflammation reduction. Thus, CSO@PM stimulates re-epithelialization and granulation-tissue formation, promoting wound healing. Moreover, this antibacterial platform exhibits no obvious toxicity at all the test concentrations in vitro and in vivo. Thus, CSO@PM exhibits a robust antibacterial effect and a strong toxin-adsorption capacity, facilitating the clinical treatment of many bacterial infections and the development of next-generation antibacterial nanoagents. Graphical Abstract |
| first_indexed | 2024-04-13T01:08:01Z |
| format | Article |
| id | doaj.art-bce5f226057b4d64b99940e17db2cc09 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-13T01:08:01Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-bce5f226057b4d64b99940e17db2cc092022-12-22T03:09:17ZengBMCJournal of Nanobiotechnology1477-31552021-11-0119111710.1186/s12951-021-01130-wIntegrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healingZaihui Peng0Xiaochun Zhang1Long Yuan2Ting Li3Yajie Chen4Hao Tian5Dandan Ma6Jun Deng7Xiaowei Qi8Xuntao Yin9Department of Breast Surgery, Southwest Hospital, Army Medical UniversityDepartment of Radiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Breast Surgery, Southwest Hospital, Army Medical UniversityDepartment of Radiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityInstitute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Army Medical UniversityDepartment of Breast Surgery, Southwest Hospital, Army Medical UniversityDepartment of Breast Surgery, Southwest Hospital, Army Medical UniversityInstitute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Army Medical UniversityDepartment of Breast Surgery, Southwest Hospital, Army Medical UniversityDepartment of Radiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityAbstract Serious infection caused by drug-resistant gram-negative bacteria and their secreted toxins (e.g., lipopolysaccharide) is a serious threat to human health. Thus, treatment strategies that efficiently kill bacteria and reducing the impact of their toxins simultaneously are urgently required. Herein, a novel antibacterial platform composed of a mesoporous copper silicate microsphere (CSO) core and a platelet membrane (PM) shell was prepared (CSO@PM). CSO@PM specifically targets bacteria owing to formyl peptide receptors on the PM and, combined with photothermal therapy (PTT), exhibits highly effective bacter icidal activity. Importantly, CSO@PM can adsorb lipopolysaccharide secreted by gram-negative bacteria, resulting in inflammation reduction. Thus, CSO@PM stimulates re-epithelialization and granulation-tissue formation, promoting wound healing. Moreover, this antibacterial platform exhibits no obvious toxicity at all the test concentrations in vitro and in vivo. Thus, CSO@PM exhibits a robust antibacterial effect and a strong toxin-adsorption capacity, facilitating the clinical treatment of many bacterial infections and the development of next-generation antibacterial nanoagents. Graphical Abstracthttps://doi.org/10.1186/s12951-021-01130-wBacterial infectionWound healingToxin adsorptionMesoporous copper silicate microspheresPhotothermal therapy |
| spellingShingle | Zaihui Peng Xiaochun Zhang Long Yuan Ting Li Yajie Chen Hao Tian Dandan Ma Jun Deng Xiaowei Qi Xuntao Yin Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing Journal of Nanobiotechnology Bacterial infection Wound healing Toxin adsorption Mesoporous copper silicate microspheres Photothermal therapy |
| title | Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing |
| title_full | Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing |
| title_fullStr | Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing |
| title_full_unstemmed | Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing |
| title_short | Integrated endotoxin-adsorption and antibacterial properties of platelet-membrane-coated copper silicate hollow microspheres for wound healing |
| title_sort | integrated endotoxin adsorption and antibacterial properties of platelet membrane coated copper silicate hollow microspheres for wound healing |
| topic | Bacterial infection Wound healing Toxin adsorption Mesoporous copper silicate microspheres Photothermal therapy |
| url | https://doi.org/10.1186/s12951-021-01130-w |
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