RND multidrug efflux-pumps: what are they good for?
Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating resistance to toxic compounds in several life forms. In bacteria, these elements are involved in intrinsic and acquired resistance to antibiotics. Unlike other well-known horizontally acquired antibiotic resistanc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-02-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00007/full |
| _version_ | 1818681281383235584 |
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| author | Carolina eAlvarez-Ortega Jorge eOlivares Jose L Martinez |
| author_facet | Carolina eAlvarez-Ortega Jorge eOlivares Jose L Martinez |
| author_sort | Carolina eAlvarez-Ortega |
| collection | DOAJ |
| description | Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating resistance to toxic compounds in several life forms. In bacteria, these elements are involved in intrinsic and acquired resistance to antibiotics. Unlike other well-known horizontally acquired antibiotic resistance determinants, the genes encoding for multidrug efflux pumps belong to the core of bacterial genomes and thus have evolved over millions of years. The selective pressure stemming from the use of antibiotics to treat bacterial infections is relatively recent in evolutionary terms. Therefore, it is unlikely that these elements have evolved in response to antibiotics. In the last years, several studies have identified numerous functions for efflux pumps that go beyond antibiotic extrusion. In this review we present some examples of these functions that range from bacterial interactions with plant or animal hosts, to the detoxification of metabolic intermediates or the maintenance of cellular homeostasis. |
| first_indexed | 2024-12-17T10:00:27Z |
| format | Article |
| id | doaj.art-bce5fb2984944e3c9a9b9bf07b507b08 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-17T10:00:27Z |
| publishDate | 2013-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-bce5fb2984944e3c9a9b9bf07b507b082022-12-21T21:53:18ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2013-02-01410.3389/fmicb.2013.0000740475RND multidrug efflux-pumps: what are they good for?Carolina eAlvarez-Ortega0Jorge eOlivares1Jose L Martinez2Centro Nacional de Biotecnología CSICCentro Nacional de Biotecnología CSICCentro Nacional de Biotecnología CSICMultidrug efflux pumps are chromosomally encoded genetic elements capable of mediating resistance to toxic compounds in several life forms. In bacteria, these elements are involved in intrinsic and acquired resistance to antibiotics. Unlike other well-known horizontally acquired antibiotic resistance determinants, the genes encoding for multidrug efflux pumps belong to the core of bacterial genomes and thus have evolved over millions of years. The selective pressure stemming from the use of antibiotics to treat bacterial infections is relatively recent in evolutionary terms. Therefore, it is unlikely that these elements have evolved in response to antibiotics. In the last years, several studies have identified numerous functions for efflux pumps that go beyond antibiotic extrusion. In this review we present some examples of these functions that range from bacterial interactions with plant or animal hosts, to the detoxification of metabolic intermediates or the maintenance of cellular homeostasis.http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00007/fullQuorum Sensingantibiotic resistanceKey words: Multidrug efflux pumpsHost/bacteria interactionsPlant/bacteria interactionsBacterial homeostasis |
| spellingShingle | Carolina eAlvarez-Ortega Jorge eOlivares Jose L Martinez RND multidrug efflux-pumps: what are they good for? Frontiers in Microbiology Quorum Sensing antibiotic resistance Key words: Multidrug efflux pumps Host/bacteria interactions Plant/bacteria interactions Bacterial homeostasis |
| title | RND multidrug efflux-pumps: what are they good for? |
| title_full | RND multidrug efflux-pumps: what are they good for? |
| title_fullStr | RND multidrug efflux-pumps: what are they good for? |
| title_full_unstemmed | RND multidrug efflux-pumps: what are they good for? |
| title_short | RND multidrug efflux-pumps: what are they good for? |
| title_sort | rnd multidrug efflux pumps what are they good for |
| topic | Quorum Sensing antibiotic resistance Key words: Multidrug efflux pumps Host/bacteria interactions Plant/bacteria interactions Bacterial homeostasis |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00007/full |
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