Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients
Background: The impact of Hepatitis C virus (HCV) RNA levels on the evolution of chronic HCV infection-related liver damage is controversial. Heavy alcohol use is believed to have a deleterious impact on the course of HCV disease, but current knowledge about the possible effect of alcohol use on HCV...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/5/716 |
| _version_ | 1797536936440627200 |
|---|---|
| author | Daniel Fuster David Nunes Debbie M. Cheng Richard Saitz Jeffrey H. Samet |
| author_facet | Daniel Fuster David Nunes Debbie M. Cheng Richard Saitz Jeffrey H. Samet |
| author_sort | Daniel Fuster |
| collection | DOAJ |
| description | Background: The impact of Hepatitis C virus (HCV) RNA levels on the evolution of chronic HCV infection-related liver damage is controversial. Heavy alcohol use is believed to have a deleterious impact on the course of HCV disease, but current knowledge about the possible effect of alcohol use on HCV RNA levels in HIV/HCV coinfected patients is limited. Methods: We examined 107 HIV/HCV-infected individuals with current or past unhealthy alcohol use to assess the association between alcohol consumption (any drinking vs. abstinent) and HCV RNA levels. Results: Participants were 75% male, with a mean age of 43 years, and 63% were on antiretroviral therapy. Mean (SD) log HIV RNA was 3.1 (1.4) and mean (SD) log HCV RNA was 6.1 (0.8). Past-month alcohol use was present in 38% of participants. In a multivariable linear regression analysis we found no significant differences in mean log HCV RNA levels between those reporting alcohol use and those who were abstinent [β (95%CI): −0.04 (−0.34, 0.26), <i>p</i> = 0.79)]. There was no significant association between any heavy drinking day and HCV RNA level (0.07, 95% CI: (−0.24, 0.38), <i>p</i> = 0.66). Conclusions: We did not detect significant associations between alcohol use and HCV RNA levels among HIV/HCV coinfected patients. |
| first_indexed | 2024-03-10T12:08:59Z |
| format | Article |
| id | doaj.art-bce617affffc41a5b3ac26b7a018b91d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T12:08:59Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-bce617affffc41a5b3ac26b7a018b91d2023-11-21T16:25:14ZengMDPI AGViruses1999-49152021-04-0113571610.3390/v13050716Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected PatientsDaniel Fuster0David Nunes1Debbie M. Cheng2Richard Saitz3Jeffrey H. Samet4Department of Internal Medicine, Addiction Unit Hospital Universitari Germans Trias i Pujol, Department of Medicine, Universitat Autònoma de Barcelona, 08916 Badalona, SpainSection of Gastroenterology, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USAClinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USAClinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USAClinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USABackground: The impact of Hepatitis C virus (HCV) RNA levels on the evolution of chronic HCV infection-related liver damage is controversial. Heavy alcohol use is believed to have a deleterious impact on the course of HCV disease, but current knowledge about the possible effect of alcohol use on HCV RNA levels in HIV/HCV coinfected patients is limited. Methods: We examined 107 HIV/HCV-infected individuals with current or past unhealthy alcohol use to assess the association between alcohol consumption (any drinking vs. abstinent) and HCV RNA levels. Results: Participants were 75% male, with a mean age of 43 years, and 63% were on antiretroviral therapy. Mean (SD) log HIV RNA was 3.1 (1.4) and mean (SD) log HCV RNA was 6.1 (0.8). Past-month alcohol use was present in 38% of participants. In a multivariable linear regression analysis we found no significant differences in mean log HCV RNA levels between those reporting alcohol use and those who were abstinent [β (95%CI): −0.04 (−0.34, 0.26), <i>p</i> = 0.79)]. There was no significant association between any heavy drinking day and HCV RNA level (0.07, 95% CI: (−0.24, 0.38), <i>p</i> = 0.66). Conclusions: We did not detect significant associations between alcohol use and HCV RNA levels among HIV/HCV coinfected patients.https://www.mdpi.com/1999-4915/13/5/716HIVchronic HCV infectionHCV RNA levelsalcohol use disorderunhealthy alcohol usealcohol |
| spellingShingle | Daniel Fuster David Nunes Debbie M. Cheng Richard Saitz Jeffrey H. Samet Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients Viruses HIV chronic HCV infection HCV RNA levels alcohol use disorder unhealthy alcohol use alcohol |
| title | Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients |
| title_full | Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients |
| title_fullStr | Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients |
| title_full_unstemmed | Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients |
| title_short | Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients |
| title_sort | alcohol consumption and hepatitis c virus hcv rna levels in hiv hcv coinfected patients |
| topic | HIV chronic HCV infection HCV RNA levels alcohol use disorder unhealthy alcohol use alcohol |
| url | https://www.mdpi.com/1999-4915/13/5/716 |
| work_keys_str_mv | AT danielfuster alcoholconsumptionandhepatitiscvirushcvrnalevelsinhivhcvcoinfectedpatients AT davidnunes alcoholconsumptionandhepatitiscvirushcvrnalevelsinhivhcvcoinfectedpatients AT debbiemcheng alcoholconsumptionandhepatitiscvirushcvrnalevelsinhivhcvcoinfectedpatients AT richardsaitz alcoholconsumptionandhepatitiscvirushcvrnalevelsinhivhcvcoinfectedpatients AT jeffreyhsamet alcoholconsumptionandhepatitiscvirushcvrnalevelsinhivhcvcoinfectedpatients |