Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler® kit
Background: New commercial STR kits have emerged with greater numbers of markers, which allows for obtaining stronger conclusions in forensic casework, which has been poorly studied in Mexico. Aim: To obtain forensic parameters and to analyse the genetic relationships, structure and admixture in sev...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-11-01
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| Series: | Annals of Human Biology |
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| Online Access: | http://dx.doi.org/10.1080/03014460.2019.1568548 |
| _version_ | 1797685592082874368 |
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| author | José Alonso Aguilar-Velázquez Gorge Locia-Aguilar Briselda López-Saucedo Sandra Deheza-Bautista Alma Faviola Favela-Mendoza Héctor Rangel-Villalobos |
| author_facet | José Alonso Aguilar-Velázquez Gorge Locia-Aguilar Briselda López-Saucedo Sandra Deheza-Bautista Alma Faviola Favela-Mendoza Héctor Rangel-Villalobos |
| author_sort | José Alonso Aguilar-Velázquez |
| collection | DOAJ |
| description | Background: New commercial STR kits have emerged with greater numbers of markers, which allows for obtaining stronger conclusions in forensic casework, which has been poorly studied in Mexico. Aim: To obtain forensic parameters and to analyse the genetic relationships, structure and admixture in seven geographic regions of Guerrero state (South, Mexico) based on the Globalfiler® kit. Subjects and methods: A total of 245 unrelated Mexican individuals from seven regions of the state of Guerrero were analysed with the Globalfiler® kit. Forensic parameters, pairwise comparisons, genetic distances, structure analysis and admixture levels were estimated. Results: Allele frequencies and forensic parameters of 22 STRs were estimated in this Mexican population sample. The combined power of exclusion and power of discrimination values were > 99.9999% and >99.99999999%, respectively. The Native American, European and African ancestries estimated in the Guerrero state population were 70.9%, 25.9% and 3.2%, respectively. Conclusion: Forensic validation of the Globalfiler® kit was performed in the Guerrero state population. The geographic isolation level seems to be the principal factor in defining genetic relationships and admixture among the Guerrero sub-populations. Despite the intrinsic limitations of STRs for admixture analysis, these results are very close to previous values based on AIMs and genome-wide SNPs. |
| first_indexed | 2024-03-12T00:47:22Z |
| format | Article |
| id | doaj.art-bce66fd9b38b49acaa622a91cd10cbf1 |
| institution | Directory Open Access Journal |
| issn | 0301-4460 1464-5033 |
| language | English |
| last_indexed | 2024-03-12T00:47:22Z |
| publishDate | 2018-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj.art-bce66fd9b38b49acaa622a91cd10cbf12023-09-14T15:36:10ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332018-11-01456-852453010.1080/03014460.2019.15685481568548Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler® kitJosé Alonso Aguilar-Velázquez0Gorge Locia-Aguilar1Briselda López-Saucedo2Sandra Deheza-Bautista3Alma Faviola Favela-Mendoza4Héctor Rangel-Villalobos5Universidad de Guadalajara, (CUCiénega-UdeG)Universidad de Guadalajara, (CUCS-UdeG)Universidad de Guadalajara, (CUCS-UdeG)Universidad de Guadalajara, (CUCS-UdeG)Universidad de Guadalajara, (CUCiénega-UdeG)Universidad de Guadalajara, (CUCiénega-UdeG)Background: New commercial STR kits have emerged with greater numbers of markers, which allows for obtaining stronger conclusions in forensic casework, which has been poorly studied in Mexico. Aim: To obtain forensic parameters and to analyse the genetic relationships, structure and admixture in seven geographic regions of Guerrero state (South, Mexico) based on the Globalfiler® kit. Subjects and methods: A total of 245 unrelated Mexican individuals from seven regions of the state of Guerrero were analysed with the Globalfiler® kit. Forensic parameters, pairwise comparisons, genetic distances, structure analysis and admixture levels were estimated. Results: Allele frequencies and forensic parameters of 22 STRs were estimated in this Mexican population sample. The combined power of exclusion and power of discrimination values were > 99.9999% and >99.99999999%, respectively. The Native American, European and African ancestries estimated in the Guerrero state population were 70.9%, 25.9% and 3.2%, respectively. Conclusion: Forensic validation of the Globalfiler® kit was performed in the Guerrero state population. The geographic isolation level seems to be the principal factor in defining genetic relationships and admixture among the Guerrero sub-populations. Despite the intrinsic limitations of STRs for admixture analysis, these results are very close to previous values based on AIMs and genome-wide SNPs.http://dx.doi.org/10.1080/03014460.2019.1568548mexican-mestizosguerrero stateadmixtureglobalfilerforensic genetics |
| spellingShingle | José Alonso Aguilar-Velázquez Gorge Locia-Aguilar Briselda López-Saucedo Sandra Deheza-Bautista Alma Faviola Favela-Mendoza Héctor Rangel-Villalobos Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler® kit Annals of Human Biology mexican-mestizos guerrero state admixture globalfiler forensic genetics |
| title | Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler® kit |
| title_full | Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler® kit |
| title_fullStr | Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler® kit |
| title_full_unstemmed | Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler® kit |
| title_short | Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler® kit |
| title_sort | forensic parameters and admixture in seven geographical regions of the guerrero state south mexico based on strs of the globalfiler r kit |
| topic | mexican-mestizos guerrero state admixture globalfiler forensic genetics |
| url | http://dx.doi.org/10.1080/03014460.2019.1568548 |
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