The Immunohistochemical Profile of Superoxide Dismutase (SOD in the Liver Tissue of Hypercholesterolemic Rats
This study was conducted to observe intracellular antioxidant cooper,zinc-superoxide dismutase (Cu,Zn-SOD) in liver tissue of rats under hypercholesterolemic condition by using immunohistochemical technique. A total of twenty male Wistar rats were used for this study. Those rats were divided into tw...
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| Format: | Article |
| Language: | English |
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Bogor Agricultural University
2006-09-01
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| Series: | Hayati Journal of Biosciences |
| Subjects: | |
| Online Access: | http://journal.ipb.ac.id/index.php/hayati/article/viewFile/212/78 |
| _version_ | 1818850993979260928 |
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| author | TUTIK WRESDIYATI MADE ASTAWAN LUSIA YUNI HASTANTI |
| author_facet | TUTIK WRESDIYATI MADE ASTAWAN LUSIA YUNI HASTANTI |
| author_sort | TUTIK WRESDIYATI |
| collection | DOAJ |
| description | This study was conducted to observe intracellular antioxidant cooper,zinc-superoxide dismutase (Cu,Zn-SOD) in liver tissue of rats under hypercholesterolemic condition by using immunohistochemical technique. A total of twenty male Wistar rats were used for this study. Those rats were divided into two groups; (i) control group and (ii) hypercholesterolemic group, which were fed died containing 1% cholesterol for eight weeks. Rat livers were taken at the end of treatment, and processed by using paraffin embedding standard method. The tissues were stained immunohistochemically to Cu,Zn-SOD. Observation of Cu,Zn-SOD content in the tissue was performed qualitatively in the cytoplasm and quantitatively in the nucleus of hepatocytes based on colour intensity of enzyme reaction product. The profile of antioxidant-Cu,Zn-SOD decreased (P < 0.05) in the hypercholesterolemic group compared to the control group. |
| first_indexed | 2024-12-19T06:57:58Z |
| format | Article |
| id | doaj.art-bce85f09d5dc4e25ab60a7938087a32b |
| institution | Directory Open Access Journal |
| issn | 1978-3019 2086-4094 |
| language | English |
| last_indexed | 2024-12-19T06:57:58Z |
| publishDate | 2006-09-01 |
| publisher | Bogor Agricultural University |
| record_format | Article |
| series | Hayati Journal of Biosciences |
| spelling | doaj.art-bce85f09d5dc4e25ab60a7938087a32b2022-12-21T20:31:29ZengBogor Agricultural UniversityHayati Journal of Biosciences1978-30192086-40942006-09-011338589The Immunohistochemical Profile of Superoxide Dismutase (SOD in the Liver Tissue of Hypercholesterolemic RatsTUTIK WRESDIYATIMADE ASTAWANLUSIA YUNI HASTANTIThis study was conducted to observe intracellular antioxidant cooper,zinc-superoxide dismutase (Cu,Zn-SOD) in liver tissue of rats under hypercholesterolemic condition by using immunohistochemical technique. A total of twenty male Wistar rats were used for this study. Those rats were divided into two groups; (i) control group and (ii) hypercholesterolemic group, which were fed died containing 1% cholesterol for eight weeks. Rat livers were taken at the end of treatment, and processed by using paraffin embedding standard method. The tissues were stained immunohistochemically to Cu,Zn-SOD. Observation of Cu,Zn-SOD content in the tissue was performed qualitatively in the cytoplasm and quantitatively in the nucleus of hepatocytes based on colour intensity of enzyme reaction product. The profile of antioxidant-Cu,Zn-SOD decreased (P < 0.05) in the hypercholesterolemic group compared to the control group.http://journal.ipb.ac.id/index.php/hayati/article/viewFile/212/78Superoxide dismutaseSODhypercholesterolemialiverrat |
| spellingShingle | TUTIK WRESDIYATI MADE ASTAWAN LUSIA YUNI HASTANTI The Immunohistochemical Profile of Superoxide Dismutase (SOD in the Liver Tissue of Hypercholesterolemic Rats Hayati Journal of Biosciences Superoxide dismutase SOD hypercholesterolemia liver rat |
| title | The Immunohistochemical Profile of Superoxide Dismutase (SOD in the Liver Tissue of Hypercholesterolemic Rats |
| title_full | The Immunohistochemical Profile of Superoxide Dismutase (SOD in the Liver Tissue of Hypercholesterolemic Rats |
| title_fullStr | The Immunohistochemical Profile of Superoxide Dismutase (SOD in the Liver Tissue of Hypercholesterolemic Rats |
| title_full_unstemmed | The Immunohistochemical Profile of Superoxide Dismutase (SOD in the Liver Tissue of Hypercholesterolemic Rats |
| title_short | The Immunohistochemical Profile of Superoxide Dismutase (SOD in the Liver Tissue of Hypercholesterolemic Rats |
| title_sort | immunohistochemical profile of superoxide dismutase sod in the liver tissue of hypercholesterolemic rats |
| topic | Superoxide dismutase SOD hypercholesterolemia liver rat |
| url | http://journal.ipb.ac.id/index.php/hayati/article/viewFile/212/78 |
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