The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer
Background/Aims Peptic ulcer bleeding is the most common cause of upper gastrointestinal tract bleeding. Platelet-rich plasma (PRP) enhances tissue repair, and is therefore used in various medical treatments. A combination of mechanical or electrothermal hemostasis has been recommended for upper gas...
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| Format: | Article |
| Language: | English |
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Korean Society of Gastrointestinal Endoscopy
2021-11-01
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| Series: | Clinical Endoscopy |
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| Online Access: | http://www.e-ce.org/upload/pdf/ce-2021-004.pdf |
| _version_ | 1797427294138007552 |
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| author | Waseem M. Seleem Amr Shaaban Hanafy |
| author_facet | Waseem M. Seleem Amr Shaaban Hanafy |
| author_sort | Waseem M. Seleem |
| collection | DOAJ |
| description | Background/Aims Peptic ulcer bleeding is the most common cause of upper gastrointestinal tract bleeding. Platelet-rich plasma (PRP) enhances tissue repair, and is therefore used in various medical treatments. A combination of mechanical or electrothermal hemostasis has been recommended for upper gastrointestinal tract bleeding treatment. This study evaluated the additive efficacy of PRP in bleeding peptic ulcer hemostasis and recovery. Methods Eighty patients with peptic ulcer bleeding were initially treated by hemoclipping, and were randomly chosen for either additional PRP (n=40) or additional epinephrine (n=40) injections. Both groups were compared with regard to achieving hemostasis and the frequency of complications. Results Hemostasis was immediately achieved in both groups. Two patients (5%) in the PRP group and 8 (20%) patients in the epinephrine group experienced rebleeding after 15.9±2.8 and 12.3±3.7 days, respectively. They were managed by PRP injection in addition to proton pump inhibitor infusion. Hemoglobin was substantially increased in the PRP-treated group with full recovery occurring in 60.5% compared to 31.3% of patients in the epinephrine group (p=0.001). There was no recurrent bleeding in the PRP group, but 4/32 (12.5%) patients in the epinephrine group exhibited rebleeding. Conclusions PRP showed additional benefit in reducing peptic ulcer bleeding with no reported significant complications. Clinical trial (NCT03733171). |
| first_indexed | 2024-03-09T08:43:08Z |
| format | Article |
| id | doaj.art-bce99bf1fe91416082599227fd4698f1 |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-09T08:43:08Z |
| publishDate | 2021-11-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-bce99bf1fe91416082599227fd4698f12023-12-02T16:21:59ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432021-11-0154686487110.5946/ce.2021.0047528The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic UlcerWaseem M. Seleem0Amr Shaaban Hanafy1 Division of Hepatogastroenterology and Endoscopy, Zagazig University, Zagazig, Egypt Division of Hepatogastroenterology and Endoscopy, Zagazig University, Zagazig, EgyptBackground/Aims Peptic ulcer bleeding is the most common cause of upper gastrointestinal tract bleeding. Platelet-rich plasma (PRP) enhances tissue repair, and is therefore used in various medical treatments. A combination of mechanical or electrothermal hemostasis has been recommended for upper gastrointestinal tract bleeding treatment. This study evaluated the additive efficacy of PRP in bleeding peptic ulcer hemostasis and recovery. Methods Eighty patients with peptic ulcer bleeding were initially treated by hemoclipping, and were randomly chosen for either additional PRP (n=40) or additional epinephrine (n=40) injections. Both groups were compared with regard to achieving hemostasis and the frequency of complications. Results Hemostasis was immediately achieved in both groups. Two patients (5%) in the PRP group and 8 (20%) patients in the epinephrine group experienced rebleeding after 15.9±2.8 and 12.3±3.7 days, respectively. They were managed by PRP injection in addition to proton pump inhibitor infusion. Hemoglobin was substantially increased in the PRP-treated group with full recovery occurring in 60.5% compared to 31.3% of patients in the epinephrine group (p=0.001). There was no recurrent bleeding in the PRP group, but 4/32 (12.5%) patients in the epinephrine group exhibited rebleeding. Conclusions PRP showed additional benefit in reducing peptic ulcer bleeding with no reported significant complications. Clinical trial (NCT03733171).http://www.e-ce.org/upload/pdf/ce-2021-004.pdfgastric ulcerhealingplatelet-rich plasmaupper gastrointestinal bleeding |
| spellingShingle | Waseem M. Seleem Amr Shaaban Hanafy The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer Clinical Endoscopy gastric ulcer healing platelet-rich plasma upper gastrointestinal bleeding |
| title | The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer |
| title_full | The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer |
| title_fullStr | The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer |
| title_full_unstemmed | The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer |
| title_short | The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer |
| title_sort | additive effect of platelet rich plasma in the treatment of actively bleeding peptic ulcer |
| topic | gastric ulcer healing platelet-rich plasma upper gastrointestinal bleeding |
| url | http://www.e-ce.org/upload/pdf/ce-2021-004.pdf |
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