Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes

Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes

Summary: Hepatitis B virus (HBV) mediates persistent infection, chronic hepatitis, and liver disease. HBV covalently closed circular (ccc)DNA is central to viral persistence such that its elimination is considered the cornerstone for HBV cure. Inefficient detection by pathogen recognition receptors...

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Bibliographic Details
Main Authors: Sooyoung Lee, Ashish Goyal, Alan S. Perelson, Yuji Ishida, Takeshi Saito, Michael Gale, Jr.
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220311664

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