Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver Count
Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor organs. Extended criteria donor (ECD) liver grafts are increasingly utilized in clinical practice to mitigate this challenge. However, impaired ischemic tolerance of t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Engineering |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095809923004630 |
| _version_ | 1827277701268897792 |
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| author | Zhoucheng Wang Jack Martin Jiongjie Yu Kai Wang Kourosh Saeb-Parsy Xiao Xu |
| author_facet | Zhoucheng Wang Jack Martin Jiongjie Yu Kai Wang Kourosh Saeb-Parsy Xiao Xu |
| author_sort | Zhoucheng Wang |
| collection | DOAJ |
| description | Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor organs. Extended criteria donor (ECD) liver grafts are increasingly utilized in clinical practice to mitigate this challenge. However, impaired ischemic tolerance of these grafts jeopardizes organ viability during cold storage. Machine perfusion (MP) was designed to improve organ preservation and reduce posttransplant complications. Nevertheless, it is increasingly evident that MP alone may not preserve ECD grafts optimally. Increasing emphasis has thus been placed on modified MP strategies, including the use of different perfusates, modified perfusion modalities, and different therapeutic interventions. Here, we introduce a novel term, “MP Plus,” denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of ECD grafts. In this review, we summarize the existing and potential modified MP strategies and discuss their advantages in reconditioning different ECD grafts in clinical settings. |
| first_indexed | 2024-04-24T07:39:05Z |
| format | Article |
| id | doaj.art-bcf1281db7454eb49806925f72ab4480 |
| institution | Directory Open Access Journal |
| issn | 2095-8099 |
| language | English |
| last_indexed | 2024-04-24T07:39:05Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Engineering |
| spelling | doaj.art-bcf1281db7454eb49806925f72ab44802024-04-20T04:17:22ZengElsevierEngineering2095-80992024-01-01322940Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver CountZhoucheng Wang0Jack Martin1Jiongjie Yu2Kai Wang3Kourosh Saeb-Parsy4Xiao Xu5Zhejiang University School of Medicine, Hangzhou 310058, China; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou 310006, ChinaDepartment of Surgery, University of Cambridge & NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK; Department of Surgery, Cambridge University Hospitals & NHS Foundation Trust, Cambridge CB2 2QQ, UKZhejiang University School of Medicine, Hangzhou 310058, China; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou 310006, ChinaZhejiang University School of Medicine, Hangzhou 310058, China; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou 310006, China; Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, ChinaDepartment of Surgery, University of Cambridge & NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK; Department of Surgery, Cambridge University Hospitals & NHS Foundation Trust, Cambridge CB2 2QQ, UK; Corresponding authors.Zhejiang University School of Medicine, Hangzhou 310058, China; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou 310006, China; Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, China; Corresponding authors.Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor organs. Extended criteria donor (ECD) liver grafts are increasingly utilized in clinical practice to mitigate this challenge. However, impaired ischemic tolerance of these grafts jeopardizes organ viability during cold storage. Machine perfusion (MP) was designed to improve organ preservation and reduce posttransplant complications. Nevertheless, it is increasingly evident that MP alone may not preserve ECD grafts optimally. Increasing emphasis has thus been placed on modified MP strategies, including the use of different perfusates, modified perfusion modalities, and different therapeutic interventions. Here, we introduce a novel term, “MP Plus,” denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of ECD grafts. In this review, we summarize the existing and potential modified MP strategies and discuss their advantages in reconditioning different ECD grafts in clinical settings.http://www.sciencedirect.com/science/article/pii/S2095809923004630Liver transplantationExtended criteria donorMachine perfusion plusOrgan shortage |
| spellingShingle | Zhoucheng Wang Jack Martin Jiongjie Yu Kai Wang Kourosh Saeb-Parsy Xiao Xu Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver Count Engineering Liver transplantation Extended criteria donor Machine perfusion plus Organ shortage |
| title | Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver Count |
| title_full | Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver Count |
| title_fullStr | Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver Count |
| title_full_unstemmed | Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver Count |
| title_short | Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver Count |
| title_sort | machine perfusion plus for extended criteria donor liver grafts making every liver count |
| topic | Liver transplantation Extended criteria donor Machine perfusion plus Organ shortage |
| url | http://www.sciencedirect.com/science/article/pii/S2095809923004630 |
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