Patch-Clamp Recordings of Action Potentials From Human Atrial Myocytes: Optimization Through Dynamic Clamp

Patch-Clamp Recordings of Action Potentials From Human Atrial Myocytes: Optimization Through Dynamic Clamp

Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Consequently, novel therapies are being developed. Ultimately, the impact of compounds on the action potential (AP) needs to be tested in freshly isolated human atrial myocytes. However, the frequent depolarized state of t...

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Bibliographic Details
Main Authors: Arie O. Verkerk, Gerard A. Marchal, Jan G. Zegers, Makiri Kawasaki, Antoine H. G. Driessen, Carol Ann Remme, Joris R. de Groot, Ronald Wilders
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
drug testing
patch clamp
human
cardiac myocytes
left atrial appendage
action potential
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.649414/full

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