Cathepsin K activity controls cachexia‐induced muscle atrophy via the modulation of IRS1 ubiquitination

Cathepsin K activity controls cachexia‐induced muscle atrophy via the modulation of IRS1 ubiquitination

Abstract Background Cachexia is a complicated metabolic disorder that is characterize by progressive atrophy of skeletal muscle. Cathepsin K (CTSK) is a widely expressed cysteine protease that has garnered attention because of its enzymatic and non‐enzymatic functions in signalling in various pathol...

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Bibliographic Details
Main Authors: Xiangkun Meng, Zhe Huang, Aiko Inoue, Hailong Wang, Ying Wan, Xueling Yue, Shengnan Xu, Xueying Jin, Guo‐Ping Shi, Masafumi Kuzuya, Xian Wu Cheng
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Cachexia
Cathepsin K
Insulin receptor substrate 1
Ubiquitination
Muscle wasting
Online Access:https://doi.org/10.1002/jcsm.12919

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