Genetic Drivers of Ileal Neuroendocrine Tumors
The genetic causes of ileal neuroendocrine tumors (ileal NETs, or I-NETs) have been a mystery. For most types of tumors, key genes were revealed by large scale genomic sequencing that demonstrated recurrent mutations of specific oncogenes or tumor suppressors. In contrast, genomic sequencing of ilea...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/20/5070 |
| _version_ | 1797515172725653504 |
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| author | Darren R. Carpizo Chris R. Harris |
| author_facet | Darren R. Carpizo Chris R. Harris |
| author_sort | Darren R. Carpizo |
| collection | DOAJ |
| description | The genetic causes of ileal neuroendocrine tumors (ileal NETs, or I-NETs) have been a mystery. For most types of tumors, key genes were revealed by large scale genomic sequencing that demonstrated recurrent mutations of specific oncogenes or tumor suppressors. In contrast, genomic sequencing of ileal NETs demonstrated a distinct lack of recurrently mutated genes, suggesting that the mechanisms that drive the formation of I-NETs may be quite different than the cell-intrinsic mutations that drive the formation of other tumor types. However, recent mouse studies have identified the IGF2 and RB1 pathways in the formation of ileal NETs, which is supported by the subsequent analysis of patient samples. Thus, ileal NETs no longer appear to be a cancer without genetic causes. |
| first_indexed | 2024-03-10T06:41:46Z |
| format | Article |
| id | doaj.art-bcf4298831e64a50a987420ae38483c6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:41:46Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bcf4298831e64a50a987420ae38483c62023-11-22T17:39:47ZengMDPI AGCancers2072-66942021-10-011320507010.3390/cancers13205070Genetic Drivers of Ileal Neuroendocrine TumorsDarren R. Carpizo0Chris R. Harris1Department of Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USADepartment of Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USAThe genetic causes of ileal neuroendocrine tumors (ileal NETs, or I-NETs) have been a mystery. For most types of tumors, key genes were revealed by large scale genomic sequencing that demonstrated recurrent mutations of specific oncogenes or tumor suppressors. In contrast, genomic sequencing of ileal NETs demonstrated a distinct lack of recurrently mutated genes, suggesting that the mechanisms that drive the formation of I-NETs may be quite different than the cell-intrinsic mutations that drive the formation of other tumor types. However, recent mouse studies have identified the IGF2 and RB1 pathways in the formation of ileal NETs, which is supported by the subsequent analysis of patient samples. Thus, ileal NETs no longer appear to be a cancer without genetic causes.https://www.mdpi.com/2072-6694/13/20/5070ilealneuroendocrine |
| spellingShingle | Darren R. Carpizo Chris R. Harris Genetic Drivers of Ileal Neuroendocrine Tumors Cancers ileal neuroendocrine |
| title | Genetic Drivers of Ileal Neuroendocrine Tumors |
| title_full | Genetic Drivers of Ileal Neuroendocrine Tumors |
| title_fullStr | Genetic Drivers of Ileal Neuroendocrine Tumors |
| title_full_unstemmed | Genetic Drivers of Ileal Neuroendocrine Tumors |
| title_short | Genetic Drivers of Ileal Neuroendocrine Tumors |
| title_sort | genetic drivers of ileal neuroendocrine tumors |
| topic | ileal neuroendocrine |
| url | https://www.mdpi.com/2072-6694/13/20/5070 |
| work_keys_str_mv | AT darrenrcarpizo geneticdriversofilealneuroendocrinetumors AT chrisrharris geneticdriversofilealneuroendocrinetumors |