The disease burden and quality of life of chronic cough patients in South Korea and Taiwan
Background: Chronic cough (CC) is a common condition, but the burden of CC in general populations remains largely unknown. This study aims to investigate the disease prevalence and burden among community-based CC patients in South Korea and Taiwan, using structured tools. Methods: A population-based...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | World Allergy Organization Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455122000576 |
| _version_ | 1818016321803124736 |
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| author | Chong-Jen Yu, MD, PhD. Woo-Jung Song, MD, PhD. Suk Hyun Kang, PhD. |
| author_facet | Chong-Jen Yu, MD, PhD. Woo-Jung Song, MD, PhD. Suk Hyun Kang, PhD. |
| author_sort | Chong-Jen Yu, MD, PhD. |
| collection | DOAJ |
| description | Background: Chronic cough (CC) is a common condition, but the burden of CC in general populations remains largely unknown. This study aims to investigate the disease prevalence and burden among community-based CC patients in South Korea and Taiwan, using structured tools. Methods: A population-based cross-sectional study uses data from the 2020 South Korea and Taiwan National Health and Wellness Survey (NHWS) as well as a CC survey conducted between January–February 2020 and March–April 2020, respectively. Health outcome measures included health-related quality of life (HRQoL), health state utilities, work productivity and activity impairment (WPAI), and measurement of depression, anxiety, and insomnia among CC patients. Results: The weighted lifetime and 12-month prevalence of CC was 6.20% and 4.34% in South Korea, and 8.27% and 5.55% in Taiwan. Compared to matched non-CC controls, CC patients reported poorer HRQoL (SF-12v2) in terms of physical component summary (PCS) score (South Korea: 47.69 ± 7.68 vs. 50.08 ± 7.29; Taiwan: 48.58 ± 7.15 vs. 50.50 ± 7.30) and mental component summary (MCS) score (44.15 ± 8.85 vs. 46.28 ± 8.50; 42.44 ± 7.78 vs. 44.60 ± 8.08), health state utilities EQ-5D index (0.73 ± 0.23 vs. 0.82 ± 0.16; 0.82 ± 0.13 vs. 0.86 ± 0.14), and more visits to healthcare professionals (7.80 vs. 4.61; 6.09 vs. 4.20) (p < 0.05). In terms of WPAI, CC patients reported higher impairments in presenteeism (32.8% vs. 21.0%; 25.9% vs. 19.4%), total work productivity (36.2% vs. 22.3%; 27.7% vs. 20.6%), and total activity (34.2% vs. 23.2%; 27.7% vs. 20.3%) than non-CC controls (p < 0.001). CC patients in South Korea and Taiwan experienced anxiety, depression, and insomnia more than non-CC controls. Poorer health outcomes were associated with the severity of CC. Patients with severe CC (visual analogue scale [VAS]>4) in both nations reported lower PCS score (45.80 vs. 49.48; 47.41 vs. 49.22) and higher absenteeism (8.5% vs. 3.6%; 5.5% vs. 1.8%) than patients with mild CC (VAS≤4) (p < 0.05). Conclusions: The findings revealed that the disease burden of CC in general populations of South Korea and Taiwan is considerable with a negative impact on the overall quality of life, social and work life, and psychological comorbidities and is significantly associated with increased severity of the CC. There is an unmet need for further treatment interventions for CC patients to relieve the burden of CC in both nations. |
| first_indexed | 2024-04-14T07:11:46Z |
| format | Article |
| id | doaj.art-bcf61fec63d94fb7ae0ca9aaecfcd515 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-04-14T07:11:46Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-bcf61fec63d94fb7ae0ca9aaecfcd5152022-12-22T02:06:25ZengElsevierWorld Allergy Organization Journal1939-45512022-09-01159100681The disease burden and quality of life of chronic cough patients in South Korea and TaiwanChong-Jen Yu, MD, PhD.0Woo-Jung Song, MD, PhD.1Suk Hyun Kang, PhD.2Department of Internal Medicine, and Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaMarket Access, MSD, Seoul, Republic of korea; Corresponding author.Background: Chronic cough (CC) is a common condition, but the burden of CC in general populations remains largely unknown. This study aims to investigate the disease prevalence and burden among community-based CC patients in South Korea and Taiwan, using structured tools. Methods: A population-based cross-sectional study uses data from the 2020 South Korea and Taiwan National Health and Wellness Survey (NHWS) as well as a CC survey conducted between January–February 2020 and March–April 2020, respectively. Health outcome measures included health-related quality of life (HRQoL), health state utilities, work productivity and activity impairment (WPAI), and measurement of depression, anxiety, and insomnia among CC patients. Results: The weighted lifetime and 12-month prevalence of CC was 6.20% and 4.34% in South Korea, and 8.27% and 5.55% in Taiwan. Compared to matched non-CC controls, CC patients reported poorer HRQoL (SF-12v2) in terms of physical component summary (PCS) score (South Korea: 47.69 ± 7.68 vs. 50.08 ± 7.29; Taiwan: 48.58 ± 7.15 vs. 50.50 ± 7.30) and mental component summary (MCS) score (44.15 ± 8.85 vs. 46.28 ± 8.50; 42.44 ± 7.78 vs. 44.60 ± 8.08), health state utilities EQ-5D index (0.73 ± 0.23 vs. 0.82 ± 0.16; 0.82 ± 0.13 vs. 0.86 ± 0.14), and more visits to healthcare professionals (7.80 vs. 4.61; 6.09 vs. 4.20) (p < 0.05). In terms of WPAI, CC patients reported higher impairments in presenteeism (32.8% vs. 21.0%; 25.9% vs. 19.4%), total work productivity (36.2% vs. 22.3%; 27.7% vs. 20.6%), and total activity (34.2% vs. 23.2%; 27.7% vs. 20.3%) than non-CC controls (p < 0.001). CC patients in South Korea and Taiwan experienced anxiety, depression, and insomnia more than non-CC controls. Poorer health outcomes were associated with the severity of CC. Patients with severe CC (visual analogue scale [VAS]>4) in both nations reported lower PCS score (45.80 vs. 49.48; 47.41 vs. 49.22) and higher absenteeism (8.5% vs. 3.6%; 5.5% vs. 1.8%) than patients with mild CC (VAS≤4) (p < 0.05). Conclusions: The findings revealed that the disease burden of CC in general populations of South Korea and Taiwan is considerable with a negative impact on the overall quality of life, social and work life, and psychological comorbidities and is significantly associated with increased severity of the CC. There is an unmet need for further treatment interventions for CC patients to relieve the burden of CC in both nations.http://www.sciencedirect.com/science/article/pii/S1939455122000576Chronic coughPrevalenceHRQoLWork productivity and activity impairmentCough severity |
| spellingShingle | Chong-Jen Yu, MD, PhD. Woo-Jung Song, MD, PhD. Suk Hyun Kang, PhD. The disease burden and quality of life of chronic cough patients in South Korea and Taiwan World Allergy Organization Journal Chronic cough Prevalence HRQoL Work productivity and activity impairment Cough severity |
| title | The disease burden and quality of life of chronic cough patients in South Korea and Taiwan |
| title_full | The disease burden and quality of life of chronic cough patients in South Korea and Taiwan |
| title_fullStr | The disease burden and quality of life of chronic cough patients in South Korea and Taiwan |
| title_full_unstemmed | The disease burden and quality of life of chronic cough patients in South Korea and Taiwan |
| title_short | The disease burden and quality of life of chronic cough patients in South Korea and Taiwan |
| title_sort | disease burden and quality of life of chronic cough patients in south korea and taiwan |
| topic | Chronic cough Prevalence HRQoL Work productivity and activity impairment Cough severity |
| url | http://www.sciencedirect.com/science/article/pii/S1939455122000576 |
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