Glia, mast cells and related: new therapeutic perspectives?
Glia exerts a pathogenic role in the development and maintenance of pain. In the past, glia was considered only support material; the glia is 70 to 90 percent of the CNS cells. Normally in a resting state, it is activated by substances released from central terminals of C fibers and releases cytokin...
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| Format: | Article |
| Language: | English |
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Publiediting
2011-09-01
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| Series: | Pathos |
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| Online Access: | http://www.pathos-journal.com/page_44.html |
| _version_ | 1811201935502475264 |
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| author | Guido Orlandini |
| author_facet | Guido Orlandini |
| author_sort | Guido Orlandini |
| collection | DOAJ |
| description | Glia exerts a pathogenic role in the development and maintenance of pain. In the past, glia was considered only support material; the glia is 70 to 90 percent of the CNS cells. Normally in a resting state, it is activated by substances released from central terminals of C fibers and releases cytokines that enhance excitatory synaptic transmission in the dorsal horn of the spinal cord (that is the basis of central sensitization), with allodynia-hyperalgesia. By analogy with the role of glia, it has been suggested the importance of the mast cell, a connective ubiquitous cell filled with granules that contain histamine, heparin, serotonin, and NGF as well as lipid droplets that contain hyaluronic acid and a cell membrane on which cannabinoid receptors 1 and 2 and vanilloid are located. Nociceptive stimuli cause mast cell degranulation and the release of substances contained in the granules.
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| first_indexed | 2024-04-12T02:30:22Z |
| format | Article |
| id | doaj.art-bcf7c138ea144e92ba226105a802be68 |
| institution | Directory Open Access Journal |
| issn | 1593-2354 1593-2354 |
| language | English |
| last_indexed | 2024-04-12T02:30:22Z |
| publishDate | 2011-09-01 |
| publisher | Publiediting |
| record_format | Article |
| series | Pathos |
| spelling | doaj.art-bcf7c138ea144e92ba226105a802be682022-12-22T03:51:49ZengPublieditingPathos1593-23541593-23542011-09-01182-3710Glia, mast cells and related: new therapeutic perspectives?Guido Orlandini0Medicina del Dolore Casa di Cura Santa Maria delle Grazie, Voghera (Pv), ItalyGlia exerts a pathogenic role in the development and maintenance of pain. In the past, glia was considered only support material; the glia is 70 to 90 percent of the CNS cells. Normally in a resting state, it is activated by substances released from central terminals of C fibers and releases cytokines that enhance excitatory synaptic transmission in the dorsal horn of the spinal cord (that is the basis of central sensitization), with allodynia-hyperalgesia. By analogy with the role of glia, it has been suggested the importance of the mast cell, a connective ubiquitous cell filled with granules that contain histamine, heparin, serotonin, and NGF as well as lipid droplets that contain hyaluronic acid and a cell membrane on which cannabinoid receptors 1 and 2 and vanilloid are located. Nociceptive stimuli cause mast cell degranulation and the release of substances contained in the granules. ___________________________________________________http://www.pathos-journal.com/page_44.htmlGliamast cellsnociceptive painneuropathic painpalmitoylethanolamide |
| spellingShingle | Guido Orlandini Glia, mast cells and related: new therapeutic perspectives? Pathos Glia mast cells nociceptive pain neuropathic pain palmitoylethanolamide |
| title | Glia, mast cells and related: new therapeutic perspectives? |
| title_full | Glia, mast cells and related: new therapeutic perspectives? |
| title_fullStr | Glia, mast cells and related: new therapeutic perspectives? |
| title_full_unstemmed | Glia, mast cells and related: new therapeutic perspectives? |
| title_short | Glia, mast cells and related: new therapeutic perspectives? |
| title_sort | glia mast cells and related new therapeutic perspectives |
| topic | Glia mast cells nociceptive pain neuropathic pain palmitoylethanolamide |
| url | http://www.pathos-journal.com/page_44.html |
| work_keys_str_mv | AT guidoorlandini gliamastcellsandrelatednewtherapeuticperspectives |