Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental Prostheses
Poly (methyl methacrylate) (PMMA) is a commonly used denture material with poor antimicrobial effects. This study investigated the antimicrobial effects of PMMA-containing silver-phosphate glass. We fabricated a novel material comprising PMMA-containing silver-phosphate glass. Then, microhardness, f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/2/297 |
| _version_ | 1797437595728216064 |
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| author | Song-Yi Yang Myung-Jin Lee |
| author_facet | Song-Yi Yang Myung-Jin Lee |
| author_sort | Song-Yi Yang |
| collection | DOAJ |
| description | Poly (methyl methacrylate) (PMMA) is a commonly used denture material with poor antimicrobial effects. This study investigated the antimicrobial effects of PMMA-containing silver-phosphate glass. We fabricated a novel material comprising PMMA-containing silver-phosphate glass. Then, microhardness, flexural strength, and gloss unit were analyzed. Antimicrobial activity against <i>Streptococcus mutans</i> and <i>Candida albicans</i> was investigated. Colony-forming units were counted, and antimicrobial rates were measured. Biocompatibility tests were performed using a colorimetric MTT assay for evaluating cell metabolic activity. The microhardness, flexural strength, and gloss unit of the experimental groups (with silver-phosphate glass) were not significantly different from those of the control group (no silver-phosphate glass) (P > 0.05), which showed clinically valid values. With increasing proportions of silver-phosphate glass, the antimicrobial activity against the two microorganisms increased (P < 0.05). Furthermore, <i>S. mutans</i> showed more than 50% antimicrobial activity in 4%, 6%, and 8% experimental groups, <i>C. albicans</i> showed more than 50% antimicrobial activity in 6% and 8% groups, and a statistically significant difference in antimicrobial activity was observed compared to the control (P < 0.05). The cell viability of the experimental groups was not significantly different from that of the control group (P > 0.05). Both control and experimental groups showed approximately 100% cell viability. These results suggest that silver-phosphate glass is a promising antimicrobial material in dentistry. |
| first_indexed | 2024-03-09T11:24:43Z |
| format | Article |
| id | doaj.art-bcf926b3f4d449209ff7614ad3247592 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T11:24:43Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-bcf926b3f4d449209ff7614ad32475922023-12-01T00:07:37ZengMDPI AGPolymers2073-43602023-01-0115229710.3390/polym15020297Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental ProsthesesSong-Yi Yang0Myung-Jin Lee1Department of Dental Hygiene, Konyang University, Daejeon 35365, Republic of KoreaDepartment of Dental Hygiene, Division of Health Science, Baekseok University, Cheonan 31065, Republic of KoreaPoly (methyl methacrylate) (PMMA) is a commonly used denture material with poor antimicrobial effects. This study investigated the antimicrobial effects of PMMA-containing silver-phosphate glass. We fabricated a novel material comprising PMMA-containing silver-phosphate glass. Then, microhardness, flexural strength, and gloss unit were analyzed. Antimicrobial activity against <i>Streptococcus mutans</i> and <i>Candida albicans</i> was investigated. Colony-forming units were counted, and antimicrobial rates were measured. Biocompatibility tests were performed using a colorimetric MTT assay for evaluating cell metabolic activity. The microhardness, flexural strength, and gloss unit of the experimental groups (with silver-phosphate glass) were not significantly different from those of the control group (no silver-phosphate glass) (P > 0.05), which showed clinically valid values. With increasing proportions of silver-phosphate glass, the antimicrobial activity against the two microorganisms increased (P < 0.05). Furthermore, <i>S. mutans</i> showed more than 50% antimicrobial activity in 4%, 6%, and 8% experimental groups, <i>C. albicans</i> showed more than 50% antimicrobial activity in 6% and 8% groups, and a statistically significant difference in antimicrobial activity was observed compared to the control (P < 0.05). The cell viability of the experimental groups was not significantly different from that of the control group (P > 0.05). Both control and experimental groups showed approximately 100% cell viability. These results suggest that silver-phosphate glass is a promising antimicrobial material in dentistry.https://www.mdpi.com/2073-4360/15/2/297antimicrobial effectdental materialssilver-phosphate glasspoly (methyl methacrylate) |
| spellingShingle | Song-Yi Yang Myung-Jin Lee Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental Prostheses Polymers antimicrobial effect dental materials silver-phosphate glass poly (methyl methacrylate) |
| title | Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental Prostheses |
| title_full | Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental Prostheses |
| title_fullStr | Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental Prostheses |
| title_full_unstemmed | Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental Prostheses |
| title_short | Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental Prostheses |
| title_sort | poly methyl methacrylate containing silver phosphate glass exhibits potent antimicrobial activity without deteriorating the mechanical and biological properties of dental prostheses |
| topic | antimicrobial effect dental materials silver-phosphate glass poly (methyl methacrylate) |
| url | https://www.mdpi.com/2073-4360/15/2/297 |
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