A Prospective Observational Study of Children with FS-Associated Hospitalization: The Implication and Outcomes of Pathogen Detection in Cerebrospinal Fluid
Fang Chen,* Fan Feng,* Dianping You, Yinghui Guo, Shuo Yang, Tong Zhao, Suzhen Sun,* Le Wang* Institute of Pediatric Research, Children’s Hospital of Hebei Province, Shijiazhuang, 050031, People’s Republic of China*These authors contributed equally to this wor...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-05-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-prospective-observational-study-of-children-with-fs-associated-hospi-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1827944438240903168 |
|---|---|
| author | Chen F Feng F You D Guo Y Yang S Zhao T Sun S Wang L |
| author_facet | Chen F Feng F You D Guo Y Yang S Zhao T Sun S Wang L |
| author_sort | Chen F |
| collection | DOAJ |
| description | Fang Chen,* Fan Feng,* Dianping You, Yinghui Guo, Shuo Yang, Tong Zhao, Suzhen Sun,* Le Wang* Institute of Pediatric Research, Children’s Hospital of Hebei Province, Shijiazhuang, 050031, People’s Republic of China*These authors contributed equally to this workCorrespondence: Le Wang, Institute of Pediatric Research, Children’s Hospital of Hebei Province, 133 Jianhua South Street, Shijiazhuang, Hebei Province, 050031, People’s Republic of China, Tel +86-0311-85911389, Email luka_wl@163.comBackground: Febrile seizures (FS) are a common cause of paediatric emergencies, but research on their aetiology and epidemiology are limited. The aim of this study was to investigate the prevalence of central nervous system (CNS) pathogenic infections in patients with FS-associated hospitalization.Methods: A prospective observational study was conducted in children under 16 years of age with FS-associated hospitalization. Demographic, clinical and laboratory data were recorded. Multiplex-PCR was performed on cerebrospinal fluid (CSF) samples for nine viruses, nine bacteria and one fungus.Results: A total of 119 children were enrolled between June 2021 and June 2022. Of these, 83.2% had a final diagnosis of FS (69.7%) or FS plus (13.4%). In addition, epilepsy and encephalitis/meningitis were also found in 16.8% (20/119). Seven pathogens were identified from 9 CSF samples (7.6%), including viruses (EV, EBV, HHV-6) and bacteria (H. influenzae, S. pneumoniae, M. tuberculosis, S. putrefaciens). There were no significant clinical or laboratory differences between children who tested positive or negative for pathogens in the CSF, except for the presentation of herpes pharyngitis. Children with encephalitis/meningitis had longer hospital stays compared with those diagnosed with FS at discharge; abnormal EEG findings were significantly more common in patients with epilepsy.Conclusion: FS-associated hospitalized children may have viral or bacterial intracranial infections. Pathogen testing of CSF is an important basis for timely antibiotic or antiviral therapy when clinical and laboratory findings make FS indistinguishable from other CNS disorders.Keywords: febrile seizure, children, CSF, infection |
| first_indexed | 2024-03-13T10:30:18Z |
| format | Article |
| id | doaj.art-bcfb5043fc4544479eecd59b68ad78ba |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-03-13T10:30:18Z |
| publishDate | 2023-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-bcfb5043fc4544479eecd59b68ad78ba2023-05-18T18:42:34ZengDove Medical PressInternational Journal of General Medicine1178-70742023-05-01Volume 161891189883819A Prospective Observational Study of Children with FS-Associated Hospitalization: The Implication and Outcomes of Pathogen Detection in Cerebrospinal FluidChen FFeng FYou DGuo YYang SZhao TSun SWang LFang Chen,* Fan Feng,* Dianping You, Yinghui Guo, Shuo Yang, Tong Zhao, Suzhen Sun,* Le Wang* Institute of Pediatric Research, Children’s Hospital of Hebei Province, Shijiazhuang, 050031, People’s Republic of China*These authors contributed equally to this workCorrespondence: Le Wang, Institute of Pediatric Research, Children’s Hospital of Hebei Province, 133 Jianhua South Street, Shijiazhuang, Hebei Province, 050031, People’s Republic of China, Tel +86-0311-85911389, Email luka_wl@163.comBackground: Febrile seizures (FS) are a common cause of paediatric emergencies, but research on their aetiology and epidemiology are limited. The aim of this study was to investigate the prevalence of central nervous system (CNS) pathogenic infections in patients with FS-associated hospitalization.Methods: A prospective observational study was conducted in children under 16 years of age with FS-associated hospitalization. Demographic, clinical and laboratory data were recorded. Multiplex-PCR was performed on cerebrospinal fluid (CSF) samples for nine viruses, nine bacteria and one fungus.Results: A total of 119 children were enrolled between June 2021 and June 2022. Of these, 83.2% had a final diagnosis of FS (69.7%) or FS plus (13.4%). In addition, epilepsy and encephalitis/meningitis were also found in 16.8% (20/119). Seven pathogens were identified from 9 CSF samples (7.6%), including viruses (EV, EBV, HHV-6) and bacteria (H. influenzae, S. pneumoniae, M. tuberculosis, S. putrefaciens). There were no significant clinical or laboratory differences between children who tested positive or negative for pathogens in the CSF, except for the presentation of herpes pharyngitis. Children with encephalitis/meningitis had longer hospital stays compared with those diagnosed with FS at discharge; abnormal EEG findings were significantly more common in patients with epilepsy.Conclusion: FS-associated hospitalized children may have viral or bacterial intracranial infections. Pathogen testing of CSF is an important basis for timely antibiotic or antiviral therapy when clinical and laboratory findings make FS indistinguishable from other CNS disorders.Keywords: febrile seizure, children, CSF, infectionhttps://www.dovepress.com/a-prospective-observational-study-of-children-with-fs-associated-hospi-peer-reviewed-fulltext-article-IJGMfebrile seizurechildrencsfinfection. |
| spellingShingle | Chen F Feng F You D Guo Y Yang S Zhao T Sun S Wang L A Prospective Observational Study of Children with FS-Associated Hospitalization: The Implication and Outcomes of Pathogen Detection in Cerebrospinal Fluid International Journal of General Medicine febrile seizure children csf infection. |
| title | A Prospective Observational Study of Children with FS-Associated Hospitalization: The Implication and Outcomes of Pathogen Detection in Cerebrospinal Fluid |
| title_full | A Prospective Observational Study of Children with FS-Associated Hospitalization: The Implication and Outcomes of Pathogen Detection in Cerebrospinal Fluid |
| title_fullStr | A Prospective Observational Study of Children with FS-Associated Hospitalization: The Implication and Outcomes of Pathogen Detection in Cerebrospinal Fluid |
| title_full_unstemmed | A Prospective Observational Study of Children with FS-Associated Hospitalization: The Implication and Outcomes of Pathogen Detection in Cerebrospinal Fluid |
| title_short | A Prospective Observational Study of Children with FS-Associated Hospitalization: The Implication and Outcomes of Pathogen Detection in Cerebrospinal Fluid |
| title_sort | prospective observational study of children with fs associated hospitalization the implication and outcomes of pathogen detection in cerebrospinal fluid |
| topic | febrile seizure children csf infection. |
| url | https://www.dovepress.com/a-prospective-observational-study-of-children-with-fs-associated-hospi-peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT chenf aprospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT fengf aprospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT youd aprospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT guoy aprospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT yangs aprospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT zhaot aprospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT suns aprospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT wangl aprospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT chenf prospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT fengf prospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT youd prospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT guoy prospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT yangs prospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT zhaot prospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT suns prospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid AT wangl prospectiveobservationalstudyofchildrenwithfsassociatedhospitalizationtheimplicationandoutcomesofpathogendetectionincerebrospinalfluid |