O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways
O-GlcNAcylation modifies proteins in serine or threonine residues in the nucleus, cytoplasm, and mitochondria. It regulates a variety of cellular biological processes and abnormal O-GlcNAcylation is associated with diabetes, cancer, cardiovascular disease, and neurodegenerative diseases. Recent evid...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2021-05-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/11443.pdf |
| _version_ | 1827606389646688256 |
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| author | Hongshuo Zhang Zhen Li Yufei Wang Ying Kong |
| author_facet | Hongshuo Zhang Zhen Li Yufei Wang Ying Kong |
| author_sort | Hongshuo Zhang |
| collection | DOAJ |
| description | O-GlcNAcylation modifies proteins in serine or threonine residues in the nucleus, cytoplasm, and mitochondria. It regulates a variety of cellular biological processes and abnormal O-GlcNAcylation is associated with diabetes, cancer, cardiovascular disease, and neurodegenerative diseases. Recent evidence has suggested that O-GlcNAcylation acts as a nutrient sensor and signal integrator to regulate metabolic signaling, and that dysregulation of its metabolism may be an important indicator of pathogenesis in disease. Here, we review the literature focusing on O-GlcNAcylation regulation in major metabolic processes, such as glucose metabolism, mitochondrial oxidation, lipid metabolism, and amino acid metabolism. We discuss its role in physiological processes, such as cellular nutrient sensing and homeostasis maintenance. O-GlcNAcylation acts as a key regulator in multiple metabolic processes and pathways. Our review will provide a better understanding of how O-GlcNAcylation coordinates metabolism and integrates molecular networks. |
| first_indexed | 2024-03-09T06:36:30Z |
| format | Article |
| id | doaj.art-bcfc15da68f842d0bebb44c3216e5c9c |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:36:30Z |
| publishDate | 2021-05-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-bcfc15da68f842d0bebb44c3216e5c9c2023-12-03T10:56:57ZengPeerJ Inc.PeerJ2167-83592021-05-019e1144310.7717/peerj.11443O-GlcNAcylation is a key regulator of multiple cellular metabolic pathwaysHongshuo ZhangZhen LiYufei WangYing KongO-GlcNAcylation modifies proteins in serine or threonine residues in the nucleus, cytoplasm, and mitochondria. It regulates a variety of cellular biological processes and abnormal O-GlcNAcylation is associated with diabetes, cancer, cardiovascular disease, and neurodegenerative diseases. Recent evidence has suggested that O-GlcNAcylation acts as a nutrient sensor and signal integrator to regulate metabolic signaling, and that dysregulation of its metabolism may be an important indicator of pathogenesis in disease. Here, we review the literature focusing on O-GlcNAcylation regulation in major metabolic processes, such as glucose metabolism, mitochondrial oxidation, lipid metabolism, and amino acid metabolism. We discuss its role in physiological processes, such as cellular nutrient sensing and homeostasis maintenance. O-GlcNAcylation acts as a key regulator in multiple metabolic processes and pathways. Our review will provide a better understanding of how O-GlcNAcylation coordinates metabolism and integrates molecular networks.https://peerj.com/articles/11443.pdfO-GlcNAcNutrient sensingGlucose uptakeGlycolysisMitochondriaLipid metabolism |
| spellingShingle | Hongshuo Zhang Zhen Li Yufei Wang Ying Kong O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways PeerJ O-GlcNAc Nutrient sensing Glucose uptake Glycolysis Mitochondria Lipid metabolism |
| title | O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways |
| title_full | O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways |
| title_fullStr | O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways |
| title_full_unstemmed | O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways |
| title_short | O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways |
| title_sort | o glcnacylation is a key regulator of multiple cellular metabolic pathways |
| topic | O-GlcNAc Nutrient sensing Glucose uptake Glycolysis Mitochondria Lipid metabolism |
| url | https://peerj.com/articles/11443.pdf |
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