O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways

O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways

O-GlcNAcylation modifies proteins in serine or threonine residues in the nucleus, cytoplasm, and mitochondria. It regulates a variety of cellular biological processes and abnormal O-GlcNAcylation is associated with diabetes, cancer, cardiovascular disease, and neurodegenerative diseases. Recent evid...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Hongshuo Zhang, Zhen Li, Yufei Wang, Ying Kong
Format:	Article
Sprog:	English
Udgivet:	PeerJ Inc. 2021-05-01
Serier:	PeerJ
Fag:	O-GlcNAc Nutrient sensing Glucose uptake Glycolysis Mitochondria Lipid metabolism
Online adgang:	https://peerj.com/articles/11443.pdf

Lignende værker

Modulation of synaptic transmission through O-GlcNAcylation
af: Seunghyo Han, et al.
Udgivet: (2024-01-01)

Potential Roles of O-GlcNAcylation in Primary Cilia- Mediated Energy Metabolism
af: Jie L. Tian, et al.
Udgivet: (2020-11-01)

O-GlcNAcylation regulates extracellular signal-regulated kinase (ERK) activation in Alzheimer’s disease
af: Sophiya John Ephrame, et al.
Udgivet: (2023-07-01)

DeepO-GlcNAc: a web server for prediction of protein O-GlcNAcylation sites using deep learning combined with attention mechanism
af: Liyuan Zhang, et al.
Udgivet: (2024-10-01)

OGT Binding Peptide-Tagged Strategy Increases Protein O-GlcNAcylation Level in <i>E. coli</i>
af: Yang Li, et al.
Udgivet: (2023-02-01)

Protective Effect and Mechanism of Xbp1s Regulating HBP/O-GlcNAcylation through GFAT1 on Brain Injury after SAH
af: Kefan Wu, et al.
Udgivet: (2023-04-01)

O‐GlcNAcylation promotes malignancy and cisplatin resistance of lung cancer by stabilising NRF2
af: Yihan Zhang, et al.
Udgivet: (2024-10-01)

Reduction in O-GlcNAcylation Mitigates the Severity of Inflammatory Response in Cerulein-Induced Acute Pancreatitis in a Mouse Model
af: Mackenzie Moore, et al.
Udgivet: (2022-02-01)

O-GlcNAcylation determines the function of the key O-GalNAc glycosyltransferase C1GalT1 in bladder cancer
af: Jiang Yazhuo, et al.
Udgivet: (2024-08-01)

MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB
af: Yihan Ma, et al.
Udgivet: (2025-01-01)

<i>O</i>-GlcNAcylation: The Underestimated Emerging Regulators of Skeletal Muscle Physiology
af: Yang Liu, et al.
Udgivet: (2022-05-01)

<i>O</i>-GlcNAcylation and Regulation of Galectin-3 in Extraembryonic Endoderm Differentiation
af: Mohamed I. Gatie, et al.
Udgivet: (2022-04-01)

Integration of O-GlcNAc into Stress Response Pathways
af: Kamau M. M. Fahie, et al.
Udgivet: (2022-11-01)

N-Acetylglucosamine (GlcNAc) Sensing, Utilization, and Functions in <i>Candida albicans</i>
af: Han Du, et al.
Udgivet: (2020-08-01)

Pancreatic β-Cell O-GlcNAc Transferase Overexpression Increases Susceptibility to Metabolic Stressors in Female Mice
af: Ramkumar Mohan, et al.
Udgivet: (2021-10-01)

Do T2DM and Hyperglycaemia Affect the Expression Levels of the Regulating Enzymes of Cellular <i>O</i>-GlcNAcylation in Human Saphenous Vein Smooth Muscle Cells?
af: Israel O. Bolanle, et al.
Udgivet: (2024-04-01)

Multi-omics after O-GlcNAc alteration identified cellular processes promoting aneuploidy after loss of O-GlcNAc transferase
af: Samuel S. Boyd, et al.
Udgivet: (2024-12-01)

Impaired bisecting GlcNAc reprogrammed M1 polarization of macrophage
af: Xin He, et al.
Udgivet: (2024-01-01)

The post-translational modification O-GlcNAc is a sensor and regulator of metabolism
af: Murielle M. Morales, et al.
Udgivet: (2024-10-01)

O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis
af: Shia Vang, et al.
Udgivet: (2024-04-01)

Characterization and chemoproteomic profiling of protein O-GlcNAcylation in SOD1-G93A mouse model
af: Yi Hao, et al.
Udgivet: (2025-02-01)

Hyperglycemia-Induced Aberrant Cell Proliferation; A Metabolic Challenge Mediated by Protein O-GlcNAc Modification
af: Tamás Nagy, et al.
Udgivet: (2019-08-01)

O-GlcNAcylation: the sweet side of epigenetics
af: Thomas Dupas, et al.
Udgivet: (2023-12-01)

O-GlcNAcylation dictates pyroptosis
af: Yue Lang, et al.
Udgivet: (2024-12-01)

Proximity Labeling-Based Identification of MGAT3 Substrates and Revelation of the Tumor-Suppressive Role of Bisecting GlcNAc in Breast Cancer via GLA Degradation
af: Bowen Wang, et al.
Udgivet: (2025-01-01)

Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity
af: Anupriya Chatterjee, et al.
Udgivet: (2020-10-01)

O-GlcNAc impacts mitophagy via the PINK1-dependent pathway
af: Ibtihal M. Alghusen, et al.
Udgivet: (2024-08-01)

E. coli-expressed SECRET AGENT O-GlcNAc modifies threonine 829 of GIGANTEA
af: Young-Cheon Kim, et al.
Udgivet: (2024-07-01)

Hyperglycemia and O-GlcNAc transferase activity drive a cancer stem cell pathway in triple-negative breast cancer
af: Saheed A. Ayodeji, et al.
Udgivet: (2023-05-01)

Influence of O-GlcNAcylation on KGN cell function
af: Abigail M. Maucieri, et al.
Udgivet: (2024-09-01)

Sodium aescinate alleviates neuropathic pain through suppressing OGT-mediated O-GlcNAc modification of TLR3 to inactivate MAPK signaling pathway
af: Rong Chen, et al.
Udgivet: (2024-10-01)

Chronic rapid eye movement sleep deprivation aggravates the pathogenesis of Alzheimer’s disease by decreasing brain O-GlcNAc cycling in mice
af: Dong Yeol Kim, et al.
Udgivet: (2024-07-01)

O-GlcNAcylation in ischemic diseases
af: Rui-Rui Shi, et al.
Udgivet: (2024-05-01)

The Emerging Role of Galectins and <i>O</i>-GlcNAc Homeostasis in Processes of Cellular Differentiation
af: Rada Tazhitdinova, et al.
Udgivet: (2020-07-01)

Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma
af: Xinyu Zhou, et al.
Udgivet: (2024-07-01)

The role of O-GlcNAcylation in bone metabolic diseases
af: Yajing Yang, et al.
Udgivet: (2024-06-01)

OGT (O-GlcNAc Transferase) Selectively Modifies Multiple Residues Unique to Lamin A
af: Dan N. Simon, et al.
Udgivet: (2018-05-01)

Editorial: O-GlcNAcylation and the immune system
af: Gerald W. Hart, et al.
Udgivet: (2024-08-01)

Role of O-GlcNAcylation in Alzheimer's disease: Insights and perspectives
af: Anjali Sharma, et al.
Udgivet: (2024-12-01)

Antioxidant activity of glucosamine and its effects on ROS production, Nrf2, and O-GlcNAc expression in HMEC-1 cells
af: B. Fernández-Rojas, et al.
Udgivet: (2023-01-01)