Deficiency of Tristetraprolin Triggers Hyperthermia through Enhancing Hypothalamic Inflammation

Deficiency of Tristetraprolin Triggers Hyperthermia through Enhancing Hypothalamic Inflammation

Tristetraprolin (TTP), an RNA-binding protein, controls the stability of RNA by capturing AU-rich elements on their target genes. It has recently been identified that TTP serves as an anti-inflammatory protein by guiding the unstable mRNAs of pro-inflammatory proteins in multiple cells. However, it...

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Bibliographic Details
Main Authors: Da Yeon Jeong, Nuri Song, Hye Rim Yang, Thai Hien Tu, Byong Seo Park, Hara Kang, Jeong Woo Park, Byung Ju Lee, Sunggu Yang, Jae Geun Kim
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
tristetraprolin
hypothalamus
inflammation
microglia
sickness response
hyperthermia
Online Access:https://www.mdpi.com/1422-0067/22/7/3328

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