Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitis
Goal. To determine the blood serum level of α2-macroglobulin (α2-MG), α1-antitrypsin (α1-AT), lactoferrin (LF) and albumin in patients with IgE-mediated and IgE-independent atopic dermatitis (AD). Materials and methods. The authors tested blood serum of 60 adult patients suffering from atopic dermat...
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| Format: | Article |
| Language: | English |
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State Scientific Center of Dermatovenereology and Cosmetology
2017-08-01
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| Series: | Vestnik Dermatologii i Venerologii |
| Subjects: | |
| Online Access: | https://www.vestnikdv.ru/jour/article/view/49 |
| _version_ | 1797707278907867136 |
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| author | A. V. Burdina V. N. Zorina N. G. Korotkiy T. V. Shkolnikova N. A. Zorin |
| author_facet | A. V. Burdina V. N. Zorina N. G. Korotkiy T. V. Shkolnikova N. A. Zorin |
| author_sort | A. V. Burdina |
| collection | DOAJ |
| description | Goal. To determine the blood serum level of α2-macroglobulin (α2-MG), α1-antitrypsin (α1-AT), lactoferrin (LF) and albumin in patients with IgE-mediated and IgE-independent atopic dermatitis (AD). Materials and methods. The authors tested blood serum of 60 adult patients suffering from atopic dermatitis at the exacerbation stage (30 patients with IgE-mediated and 30 patients with IgE-independent atopic dermatitis) and 20 healthy donors in order to determine the level of these proteins by rocket immunoelectrophoresis, enzyme-linked immunosorbent assay and immunoturbidimetry methods. Major results. The albumin level is reliably reduced in case of IgE-mediated AD while the LF and α1-AT levels are increased, and concentrations of LF α1-AT and a2-MG are increased as compared to healthy people. There are differences between the level of LF, α2-MG and α1-AT. There was a statistically significant correlation between the LF levels and SCORAD score in both forms, and α2-MG and α1-AT only in case of IgE-independent AD. Conclusion. These results confirm the difference in the roles of these polyfunctional proteins in the pathogenesis of IgE-mediated and IgE-independent AD. |
| first_indexed | 2024-03-12T06:05:05Z |
| format | Article |
| id | doaj.art-bcfd6f15e2244269ab1a34d9ff1ea7a2 |
| institution | Directory Open Access Journal |
| issn | 0042-4609 2313-6294 |
| language | English |
| last_indexed | 2024-03-12T06:05:05Z |
| publishDate | 2017-08-01 |
| publisher | State Scientific Center of Dermatovenereology and Cosmetology |
| record_format | Article |
| series | Vestnik Dermatologii i Venerologii |
| spelling | doaj.art-bcfd6f15e2244269ab1a34d9ff1ea7a22023-09-03T03:45:23ZengState Scientific Center of Dermatovenereology and CosmetologyVestnik Dermatologii i Venerologii0042-46092313-62942017-08-0104353910.25208/0042-4609-2014-0-4-35-3948Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitisA. V. Burdina0V. N. Zorina1N. G. Korotkiy2T. V. Shkolnikova3N. A. Zorin4Novokuznetsk State Institute of Postgraduate MedicineNovokuznetsk State Institute of Postgraduate MedicinePirogov Russian National Research Medical UniversityNovokuznetsk State Institute of Postgraduate MedicineNovokuznetsk State Institute of Postgraduate MedicineGoal. To determine the blood serum level of α2-macroglobulin (α2-MG), α1-antitrypsin (α1-AT), lactoferrin (LF) and albumin in patients with IgE-mediated and IgE-independent atopic dermatitis (AD). Materials and methods. The authors tested blood serum of 60 adult patients suffering from atopic dermatitis at the exacerbation stage (30 patients with IgE-mediated and 30 patients with IgE-independent atopic dermatitis) and 20 healthy donors in order to determine the level of these proteins by rocket immunoelectrophoresis, enzyme-linked immunosorbent assay and immunoturbidimetry methods. Major results. The albumin level is reliably reduced in case of IgE-mediated AD while the LF and α1-AT levels are increased, and concentrations of LF α1-AT and a2-MG are increased as compared to healthy people. There are differences between the level of LF, α2-MG and α1-AT. There was a statistically significant correlation between the LF levels and SCORAD score in both forms, and α2-MG and α1-AT only in case of IgE-independent AD. Conclusion. These results confirm the difference in the roles of these polyfunctional proteins in the pathogenesis of IgE-mediated and IgE-independent AD.https://www.vestnikdv.ru/jour/article/view/49атопический дерматитпатогенезigęа<sub>2</sub>-макроглобулина<sub>1</sub>-антитрипсинлактоферринatopic dermatitispathogenesisigęa<sub>2</sub>-macroglobulinα<sub>1</sub>-antitrypsinlactoferrin |
| spellingShingle | A. V. Burdina V. N. Zorina N. G. Korotkiy T. V. Shkolnikova N. A. Zorin Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitis Vestnik Dermatologii i Venerologii атопический дерматит патогенез igę а<sub>2</sub>-макроглобулин а<sub>1</sub>-антитрипсин лактоферрин atopic dermatitis pathogenesis igę a<sub>2</sub>-macroglobulin α<sub>1</sub>-antitrypsin lactoferrin |
| title | Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitis |
| title_full | Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitis |
| title_fullStr | Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitis |
| title_full_unstemmed | Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitis |
| title_short | Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitis |
| title_sort | acute inflammation phase proteins in cases of ige mediated and ige independent atopic dermatitis |
| topic | атопический дерматит патогенез igę а<sub>2</sub>-макроглобулин а<sub>1</sub>-антитрипсин лактоферрин atopic dermatitis pathogenesis igę a<sub>2</sub>-macroglobulin α<sub>1</sub>-antitrypsin lactoferrin |
| url | https://www.vestnikdv.ru/jour/article/view/49 |
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