Temporal association between antibiotic use and resistance in Gram-negative bacteria
Abstract The β-lactam/lactamase inhibitors (BLBLIs) combination drugs are considered an effective alternative to carbapenems. However, there is a growing concern that the increased use of BLBLIs may lead to increased resistance. This study determined the temporal association between the consumption...
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| Format: | Article |
| Language: | English |
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Instituto Internacional de Ecologia
2021-09-01
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| Series: | Brazilian Journal of Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100237&tlng=en |
| _version_ | 1818973221989384192 |
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| author | X. Wu G. Zhong H. Wang J. Zhu |
| author_facet | X. Wu G. Zhong H. Wang J. Zhu |
| author_sort | X. Wu |
| collection | DOAJ |
| description | Abstract The β-lactam/lactamase inhibitors (BLBLIs) combination drugs are considered an effective alternative to carbapenems. However, there is a growing concern that the increased use of BLBLIs may lead to increased resistance. This study determined the temporal association between the consumption of BLBLI and the antimicrobial resistance in Gram-negative bacteria. In this retrospective study, electronic data on the Gram-negative bacterial isolates, including A. baumannii, P. aeruginosa, E. coli, and K. pneumoniae from in-patients and susceptibility testing results were retrieved from the medical records of the clinical laboratory. A linear regression and cross-correlation analysis were performed on the acquired data. Increasing trends (p<0.05) in the consumption of BIBLI and carbapenem with a median use of 27.68 and 34.46 DDD/1000 PD per quarter were observed, respectively. A decreased trend (p=0.023) in the consumption of fluoroquinolones with a median use of 29.13 DDD/1000 PD per quarter was observed. The resistance rate of K. pneumoniae was synchronized with the BIBLI and carbapenem consumptions with a correlation coefficient of 0.893 (p=0.012) and 0.951 (p=0.016), respectively. The cross-correlation analysis against the consumption of BIBLI and meropenem resistant K. pneumoniae was peaked at 0-quarter lag (r=951, p=0.016). There was an increasing trend in the consumption of BLBLI and carbapenems. The increasing trend in the rates of resistance to piperacillin/tazobactam, in line with the increasing consumption of BLBLI, suggests that BLBLI has to be used with caution and cannot be directly considered as a long-term alternative to carbapenems. |
| first_indexed | 2024-12-20T15:20:44Z |
| format | Article |
| id | doaj.art-bcfe9679f8ea46028b979f34f114a751 |
| institution | Directory Open Access Journal |
| issn | 1678-4375 |
| language | English |
| last_indexed | 2024-12-20T15:20:44Z |
| publishDate | 2021-09-01 |
| publisher | Instituto Internacional de Ecologia |
| record_format | Article |
| series | Brazilian Journal of Biology |
| spelling | doaj.art-bcfe9679f8ea46028b979f34f114a7512022-12-21T19:36:03ZengInstituto Internacional de EcologiaBrazilian Journal of Biology1678-43752021-09-018310.1590/1519-6984.239323Temporal association between antibiotic use and resistance in Gram-negative bacteriaX. Wuhttps://orcid.org/0000-0002-0141-6505G. Zhonghttps://orcid.org/0000-0002-5803-6482H. Wanghttps://orcid.org/0000-0002-4396-2774J. Zhuhttps://orcid.org/0000-0001-6310-9706Abstract The β-lactam/lactamase inhibitors (BLBLIs) combination drugs are considered an effective alternative to carbapenems. However, there is a growing concern that the increased use of BLBLIs may lead to increased resistance. This study determined the temporal association between the consumption of BLBLI and the antimicrobial resistance in Gram-negative bacteria. In this retrospective study, electronic data on the Gram-negative bacterial isolates, including A. baumannii, P. aeruginosa, E. coli, and K. pneumoniae from in-patients and susceptibility testing results were retrieved from the medical records of the clinical laboratory. A linear regression and cross-correlation analysis were performed on the acquired data. Increasing trends (p<0.05) in the consumption of BIBLI and carbapenem with a median use of 27.68 and 34.46 DDD/1000 PD per quarter were observed, respectively. A decreased trend (p=0.023) in the consumption of fluoroquinolones with a median use of 29.13 DDD/1000 PD per quarter was observed. The resistance rate of K. pneumoniae was synchronized with the BIBLI and carbapenem consumptions with a correlation coefficient of 0.893 (p=0.012) and 0.951 (p=0.016), respectively. The cross-correlation analysis against the consumption of BIBLI and meropenem resistant K. pneumoniae was peaked at 0-quarter lag (r=951, p=0.016). There was an increasing trend in the consumption of BLBLI and carbapenems. The increasing trend in the rates of resistance to piperacillin/tazobactam, in line with the increasing consumption of BLBLI, suggests that BLBLI has to be used with caution and cannot be directly considered as a long-term alternative to carbapenems.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100237&tlng=enβ-lactam/lactamase inhibitorstemporal association of antibiotic resistanceGram-negative bacteria |
| spellingShingle | X. Wu G. Zhong H. Wang J. Zhu Temporal association between antibiotic use and resistance in Gram-negative bacteria Brazilian Journal of Biology β-lactam/lactamase inhibitors temporal association of antibiotic resistance Gram-negative bacteria |
| title | Temporal association between antibiotic use and resistance in Gram-negative bacteria |
| title_full | Temporal association between antibiotic use and resistance in Gram-negative bacteria |
| title_fullStr | Temporal association between antibiotic use and resistance in Gram-negative bacteria |
| title_full_unstemmed | Temporal association between antibiotic use and resistance in Gram-negative bacteria |
| title_short | Temporal association between antibiotic use and resistance in Gram-negative bacteria |
| title_sort | temporal association between antibiotic use and resistance in gram negative bacteria |
| topic | β-lactam/lactamase inhibitors temporal association of antibiotic resistance Gram-negative bacteria |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100237&tlng=en |
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