A Long Journey into the Investigation of the Structure–Dynamics–Function Paradigm in Proteins through the Activities of the Palermo Biophysics Group
An overview of the biophysics activity at the Department of Physics and Chemistry Emilio Segrè of the University of Palermo is given. For forty years, the focus of the research has been on the protein structure–dynamics–function paradigm, with the aim of understanding the molecular basis of the rele...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biophysica |
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| Online Access: | https://www.mdpi.com/2673-4125/2/4/40 |
| _version_ | 1797461237923053568 |
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| author | Grazia Cottone Antonio Cupane Maurizio Leone Valeria Vetri Valeria Militello |
| author_facet | Grazia Cottone Antonio Cupane Maurizio Leone Valeria Vetri Valeria Militello |
| author_sort | Grazia Cottone |
| collection | DOAJ |
| description | An overview of the biophysics activity at the Department of Physics and Chemistry Emilio Segrè of the University of Palermo is given. For forty years, the focus of the research has been on the protein structure–dynamics–function paradigm, with the aim of understanding the molecular basis of the relevant mechanisms and the key role of solvent. At least three research lines are identified; the main results obtained in collaboration with other groups in Italy and abroad are presented. This review is dedicated to the memory of Professors Massimo Ugo Palma, Maria Beatrice Palma Vittorelli, and Lorenzo Cordone, which were the founders of the Palermo School of Biophysics. We all have been, directly or indirectly, their pupils; we miss their enthusiasm for scientific research, their deep physical insights, their suggestions, their strict but always constructive criticisms, and, most of all, their friendship. This paper is dedicated also to the memory of Prof. Hans Frauenfelder, whose pioneering works on nonexponential rebinding kinetics, protein substates, and energy landscape have inspired a large part of our work in the field of protein dynamics. |
| first_indexed | 2024-03-09T17:16:33Z |
| format | Article |
| id | doaj.art-bcfefd69b68640698a6d2ee34868aaac |
| institution | Directory Open Access Journal |
| issn | 2673-4125 |
| language | English |
| last_indexed | 2024-03-09T17:16:33Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biophysica |
| spelling | doaj.art-bcfefd69b68640698a6d2ee34868aaac2023-11-24T13:35:38ZengMDPI AGBiophysica2673-41252022-11-012445247410.3390/biophysica2040040A Long Journey into the Investigation of the Structure–Dynamics–Function Paradigm in Proteins through the Activities of the Palermo Biophysics GroupGrazia Cottone0Antonio Cupane1Maurizio Leone2Valeria Vetri3Valeria Militello4Department of Physics and Chemistry Emilio Segrè, University of Palermo, 90128 Palermo, ItalyDepartment of Physics and Chemistry Emilio Segrè, University of Palermo, 90128 Palermo, ItalyDepartment of Physics and Chemistry Emilio Segrè, University of Palermo, 90128 Palermo, ItalyDepartment of Physics and Chemistry Emilio Segrè, University of Palermo, 90128 Palermo, ItalyDepartment of Physics and Chemistry Emilio Segrè, University of Palermo, 90128 Palermo, ItalyAn overview of the biophysics activity at the Department of Physics and Chemistry Emilio Segrè of the University of Palermo is given. For forty years, the focus of the research has been on the protein structure–dynamics–function paradigm, with the aim of understanding the molecular basis of the relevant mechanisms and the key role of solvent. At least three research lines are identified; the main results obtained in collaboration with other groups in Italy and abroad are presented. This review is dedicated to the memory of Professors Massimo Ugo Palma, Maria Beatrice Palma Vittorelli, and Lorenzo Cordone, which were the founders of the Palermo School of Biophysics. We all have been, directly or indirectly, their pupils; we miss their enthusiasm for scientific research, their deep physical insights, their suggestions, their strict but always constructive criticisms, and, most of all, their friendship. This paper is dedicated also to the memory of Prof. Hans Frauenfelder, whose pioneering works on nonexponential rebinding kinetics, protein substates, and energy landscape have inspired a large part of our work in the field of protein dynamics.https://www.mdpi.com/2673-4125/2/4/40spectroscopyaggregationsimulationwateramyloidsaccharides |
| spellingShingle | Grazia Cottone Antonio Cupane Maurizio Leone Valeria Vetri Valeria Militello A Long Journey into the Investigation of the Structure–Dynamics–Function Paradigm in Proteins through the Activities of the Palermo Biophysics Group Biophysica spectroscopy aggregation simulation water amyloid saccharides |
| title | A Long Journey into the Investigation of the Structure–Dynamics–Function Paradigm in Proteins through the Activities of the Palermo Biophysics Group |
| title_full | A Long Journey into the Investigation of the Structure–Dynamics–Function Paradigm in Proteins through the Activities of the Palermo Biophysics Group |
| title_fullStr | A Long Journey into the Investigation of the Structure–Dynamics–Function Paradigm in Proteins through the Activities of the Palermo Biophysics Group |
| title_full_unstemmed | A Long Journey into the Investigation of the Structure–Dynamics–Function Paradigm in Proteins through the Activities of the Palermo Biophysics Group |
| title_short | A Long Journey into the Investigation of the Structure–Dynamics–Function Paradigm in Proteins through the Activities of the Palermo Biophysics Group |
| title_sort | long journey into the investigation of the structure dynamics function paradigm in proteins through the activities of the palermo biophysics group |
| topic | spectroscopy aggregation simulation water amyloid saccharides |
| url | https://www.mdpi.com/2673-4125/2/4/40 |
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