Cytopenia associated with copper deficiency
Abstract Introduction Due to an increased incidence of copper deficiency, we investigated adult patients who had low serum levels of copper with cytopenia at our hospital from March 2014 to March 2021. Methods We retrospectively reviewed the clinical data of patients who had been diagnosed with cyto...
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| Format: | Article |
| Language: | English |
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Wiley
2021-11-01
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| Series: | eJHaem |
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| Online Access: | https://doi.org/10.1002/jha2.278 |
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| author | Kaori Uchino Lam Vu Quang Megumi Enomoto Yuta Nakano Saki Yamada Saori Matsumura Jo Kanasugi Soichi Takasugi Ayano Nakamura Tomohiro Horio Satsuki Murakami Mineaki Goto Shohei Mizuno Hidesuke Yamamoto Masaya Watarai Ichiro Hanamura Akiyoshi Takami |
| author_facet | Kaori Uchino Lam Vu Quang Megumi Enomoto Yuta Nakano Saki Yamada Saori Matsumura Jo Kanasugi Soichi Takasugi Ayano Nakamura Tomohiro Horio Satsuki Murakami Mineaki Goto Shohei Mizuno Hidesuke Yamamoto Masaya Watarai Ichiro Hanamura Akiyoshi Takami |
| author_sort | Kaori Uchino |
| collection | DOAJ |
| description | Abstract Introduction Due to an increased incidence of copper deficiency, we investigated adult patients who had low serum levels of copper with cytopenia at our hospital from March 2014 to March 2021. Methods We retrospectively reviewed the clinical data of patients who had been diagnosed with cytopenia due to copper deficiency at the Aichi Medical University Hospital from March 2014 to March 2021. Results In the 15 patients with cytopenia secondary to low serum copper level, 11 had cytopenia of two to three lineages; three (27%) had pancytopenia, and eight (73%) had bicytopenia. Of the 15 patients, nine (60%) underwent bone marrow examinations; three (30%) showed typical morphologic features associated with copper deficiency, such as multiple clear cytoplasmic vacuoles in erythroblasts and myeloid cells, and three (30%) showed dysplastic features as observed in myelodysplastic syndrome. Among the 14 (93%) patients who were treated with copper supplements, had cessation of zinc supplements, or both, 11 (73%) and eight (53%) showed normal copper levels and hematological improvement, respectively. Conclusion Copper deficiency is more common than expected and should be considered in patients with unexplained cytopenia. |
| first_indexed | 2024-03-12T14:08:04Z |
| format | Article |
| id | doaj.art-bd0001a5b49e4f27833028bc9a35b610 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-12T14:08:04Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-bd0001a5b49e4f27833028bc9a35b6102023-08-21T14:05:23ZengWileyeJHaem2688-61462021-11-012472973710.1002/jha2.278Cytopenia associated with copper deficiencyKaori Uchino0Lam Vu Quang1Megumi Enomoto2Yuta Nakano3Saki Yamada4Saori Matsumura5Jo Kanasugi6Soichi Takasugi7Ayano Nakamura8Tomohiro Horio9Satsuki Murakami10Mineaki Goto11Shohei Mizuno12Hidesuke Yamamoto13Masaya Watarai14Ichiro Hanamura15Akiyoshi Takami16Division of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDepartment of Clinical Laboratory Aichi Medical University Hospital Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanDivision of Hematology, Department of Internal Medicine Aichi Medical University School of Medicine Nagakute JapanAbstract Introduction Due to an increased incidence of copper deficiency, we investigated adult patients who had low serum levels of copper with cytopenia at our hospital from March 2014 to March 2021. Methods We retrospectively reviewed the clinical data of patients who had been diagnosed with cytopenia due to copper deficiency at the Aichi Medical University Hospital from March 2014 to March 2021. Results In the 15 patients with cytopenia secondary to low serum copper level, 11 had cytopenia of two to three lineages; three (27%) had pancytopenia, and eight (73%) had bicytopenia. Of the 15 patients, nine (60%) underwent bone marrow examinations; three (30%) showed typical morphologic features associated with copper deficiency, such as multiple clear cytoplasmic vacuoles in erythroblasts and myeloid cells, and three (30%) showed dysplastic features as observed in myelodysplastic syndrome. Among the 14 (93%) patients who were treated with copper supplements, had cessation of zinc supplements, or both, 11 (73%) and eight (53%) showed normal copper levels and hematological improvement, respectively. Conclusion Copper deficiency is more common than expected and should be considered in patients with unexplained cytopenia.https://doi.org/10.1002/jha2.278copper deficiencycytopeniacytoplasmic vacuoleszinc supplements |
| spellingShingle | Kaori Uchino Lam Vu Quang Megumi Enomoto Yuta Nakano Saki Yamada Saori Matsumura Jo Kanasugi Soichi Takasugi Ayano Nakamura Tomohiro Horio Satsuki Murakami Mineaki Goto Shohei Mizuno Hidesuke Yamamoto Masaya Watarai Ichiro Hanamura Akiyoshi Takami Cytopenia associated with copper deficiency eJHaem copper deficiency cytopenia cytoplasmic vacuoles zinc supplements |
| title | Cytopenia associated with copper deficiency |
| title_full | Cytopenia associated with copper deficiency |
| title_fullStr | Cytopenia associated with copper deficiency |
| title_full_unstemmed | Cytopenia associated with copper deficiency |
| title_short | Cytopenia associated with copper deficiency |
| title_sort | cytopenia associated with copper deficiency |
| topic | copper deficiency cytopenia cytoplasmic vacuoles zinc supplements |
| url | https://doi.org/10.1002/jha2.278 |
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