Increased amplitude of low frequency fluctuations but normal hippocampal-default mode network connectivity in schizophrenia
Background: Clinical and preclinical studies have established that the hippocampus is hyperactive in schizophrenia, making it a possible biomarker for drug development. Increased hippocampal connectivity, which can be studied conveniently with resting state imaging, has been proposed as a readily ac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-06-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00092/full |
| _version_ | 1818149238433906688 |
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| author | Maureen eMcHugo Baxter P Rogers Pratik eTalati Pratik eTalati Neil D Woodward Stephan eHeckers |
| author_facet | Maureen eMcHugo Baxter P Rogers Pratik eTalati Pratik eTalati Neil D Woodward Stephan eHeckers |
| author_sort | Maureen eMcHugo |
| collection | DOAJ |
| description | Background: Clinical and preclinical studies have established that the hippocampus is hyperactive in schizophrenia, making it a possible biomarker for drug development. Increased hippocampal connectivity, which can be studied conveniently with resting state imaging, has been proposed as a readily accessible corollary of hippocampal hyperactivity. Here we tested the hypothesis that hippocampal activity and connectivity are increased in patients with schizophrenia.Methods: Sixty-three schizophrenia patients and 71 healthy control subjects completed a resting state functional magnetic resonance imaging scan. We assessed hippocampal activity with the amplitude of low frequency fluctuations. We analyzed hippocampal functional connectivity using three common methods: group and single subject level independent component analysis, and seed-based functional connectivity. Results: In patients with schizophrenia, we observed increased amplitude of low frequency fluctuations but normal hippocampal connectivity using independent component and seed-based analyses.Conclusions: Our results indicate that although intrinsic hippocampal activity may be increased in schizophrenia, this finding does not extend to functional connectivity. Neuroimaging methods that directly assess hippocampal activity may be more promising for the identification of a biomarker for schizophrenia. |
| first_indexed | 2024-12-11T13:03:52Z |
| format | Article |
| id | doaj.art-bd00bcdbaf4f48bb88a7ef8da2bb3ce1 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-11T13:03:52Z |
| publishDate | 2015-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-bd00bcdbaf4f48bb88a7ef8da2bb3ce12022-12-22T01:06:23ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402015-06-01610.3389/fpsyt.2015.00092139299Increased amplitude of low frequency fluctuations but normal hippocampal-default mode network connectivity in schizophreniaMaureen eMcHugo0Baxter P Rogers1Pratik eTalati2Pratik eTalati3Neil D Woodward4Stephan eHeckers5Vanderbilt UniversityVanderbilt UniversityVanderbilt UniversityVanderbilt UniversityVanderbilt UniversityVanderbilt UniversityBackground: Clinical and preclinical studies have established that the hippocampus is hyperactive in schizophrenia, making it a possible biomarker for drug development. Increased hippocampal connectivity, which can be studied conveniently with resting state imaging, has been proposed as a readily accessible corollary of hippocampal hyperactivity. Here we tested the hypothesis that hippocampal activity and connectivity are increased in patients with schizophrenia.Methods: Sixty-three schizophrenia patients and 71 healthy control subjects completed a resting state functional magnetic resonance imaging scan. We assessed hippocampal activity with the amplitude of low frequency fluctuations. We analyzed hippocampal functional connectivity using three common methods: group and single subject level independent component analysis, and seed-based functional connectivity. Results: In patients with schizophrenia, we observed increased amplitude of low frequency fluctuations but normal hippocampal connectivity using independent component and seed-based analyses.Conclusions: Our results indicate that although intrinsic hippocampal activity may be increased in schizophrenia, this finding does not extend to functional connectivity. Neuroimaging methods that directly assess hippocampal activity may be more promising for the identification of a biomarker for schizophrenia.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00092/fullHippocampusNeuroimagingSchizophreniaconnectivityfMRIbiomarkers |
| spellingShingle | Maureen eMcHugo Baxter P Rogers Pratik eTalati Pratik eTalati Neil D Woodward Stephan eHeckers Increased amplitude of low frequency fluctuations but normal hippocampal-default mode network connectivity in schizophrenia Frontiers in Psychiatry Hippocampus Neuroimaging Schizophrenia connectivity fMRI biomarkers |
| title | Increased amplitude of low frequency fluctuations but normal hippocampal-default mode network connectivity in schizophrenia |
| title_full | Increased amplitude of low frequency fluctuations but normal hippocampal-default mode network connectivity in schizophrenia |
| title_fullStr | Increased amplitude of low frequency fluctuations but normal hippocampal-default mode network connectivity in schizophrenia |
| title_full_unstemmed | Increased amplitude of low frequency fluctuations but normal hippocampal-default mode network connectivity in schizophrenia |
| title_short | Increased amplitude of low frequency fluctuations but normal hippocampal-default mode network connectivity in schizophrenia |
| title_sort | increased amplitude of low frequency fluctuations but normal hippocampal default mode network connectivity in schizophrenia |
| topic | Hippocampus Neuroimaging Schizophrenia connectivity fMRI biomarkers |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00092/full |
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