Bone Marrow Transplantation 1957-2019
Clinical bone marrow transplantation started in 1957 at a time when remarkably little was known about hematopoietic stems cells, immune responses to transplants or the identity of transplant antigens. This review will delineate the substantial increase in knowledge about these three areas gained bet...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01246/full |
| _version_ | 1819050709800189952 |
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| author | Elizabeth Simpson Francesco Dazzi |
| author_facet | Elizabeth Simpson Francesco Dazzi |
| author_sort | Elizabeth Simpson |
| collection | DOAJ |
| description | Clinical bone marrow transplantation started in 1957 at a time when remarkably little was known about hematopoietic stems cells, immune responses to transplants or the identity of transplant antigens. This review will delineate the substantial increase in knowledge about these three areas gained between then and 1992 when the Ceppellini School course on Bone Marrow Transplantation was held, along with the progress made in clinical application, as well as the stumbling blocks that remained to be overcome by further research to advance knowledge. It will outline the significant progress made between 1992 and the present year, 2019, and the remaining problems. |
| first_indexed | 2024-12-21T11:52:22Z |
| format | Article |
| id | doaj.art-bd01ccd0f58544ad9745f29354e56984 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T11:52:22Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bd01ccd0f58544ad9745f29354e569842022-12-21T19:05:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-06-011010.3389/fimmu.2019.01246453871Bone Marrow Transplantation 1957-2019Elizabeth Simpson0Francesco Dazzi1Division of Immunology & Inflammation, Department of Medicine, Imperial College London, London, United KingdomDivision of Cancer Studies, King's College London, London, United KingdomClinical bone marrow transplantation started in 1957 at a time when remarkably little was known about hematopoietic stems cells, immune responses to transplants or the identity of transplant antigens. This review will delineate the substantial increase in knowledge about these three areas gained between then and 1992 when the Ceppellini School course on Bone Marrow Transplantation was held, along with the progress made in clinical application, as well as the stumbling blocks that remained to be overcome by further research to advance knowledge. It will outline the significant progress made between 1992 and the present year, 2019, and the remaining problems.https://www.frontiersin.org/article/10.3389/fimmu.2019.01246/fulltransplantationhistocompatibilitygraft-vs.-hostgraft-vs.-tumourimmunosuppression |
| spellingShingle | Elizabeth Simpson Francesco Dazzi Bone Marrow Transplantation 1957-2019 Frontiers in Immunology transplantation histocompatibility graft-vs.-host graft-vs.-tumour immunosuppression |
| title | Bone Marrow Transplantation 1957-2019 |
| title_full | Bone Marrow Transplantation 1957-2019 |
| title_fullStr | Bone Marrow Transplantation 1957-2019 |
| title_full_unstemmed | Bone Marrow Transplantation 1957-2019 |
| title_short | Bone Marrow Transplantation 1957-2019 |
| title_sort | bone marrow transplantation 1957 2019 |
| topic | transplantation histocompatibility graft-vs.-host graft-vs.-tumour immunosuppression |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01246/full |
| work_keys_str_mv | AT elizabethsimpson bonemarrowtransplantation19572019 AT francescodazzi bonemarrowtransplantation19572019 |