Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy—An Integrated View into Other Neoplasms and Chemokine Networks
Cutaneous melanoma accounts for only about 7% of skin cancers but is causing almost 90% of deaths. Melanoma cells have a distinct repertoire of mutations from other cancers, a high plasticity and degree of mimicry toward vascular phenotype, stemness markers, versatility in evading and suppress host...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/1/120 |
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| author | Anca Filimon Iulia A. Preda Adina F. Boloca Gabriela Negroiu |
| author_facet | Anca Filimon Iulia A. Preda Adina F. Boloca Gabriela Negroiu |
| author_sort | Anca Filimon |
| collection | DOAJ |
| description | Cutaneous melanoma accounts for only about 7% of skin cancers but is causing almost 90% of deaths. Melanoma cells have a distinct repertoire of mutations from other cancers, a high plasticity and degree of mimicry toward vascular phenotype, stemness markers, versatility in evading and suppress host immune control. They exert a significant influence on immune, endothelial and various stromal cells which form tumor microenvironment. The metastatic stage, the leading cause of mortality in this neoplasm, is the outcome of a complex, still poorly understood, cross-talk between tumor and other cell phenotypes. There is accumulating evidence that Interleukin-8 (IL-8) is emblematic for advanced melanomas. This work aimed to present an updated status of IL-8 in melanoma tumor cellular complexity, through a comprehensive analysis including data from other chemokines and neoplasms. The multiple processes and mechanisms surveyed here demonstrate that IL-8 operates following orchestrated programs within signaling webs in melanoma, stromal and vascular cells. Importantly, the yet unknown molecularity regulating IL-8 impact on cells of the immune system could be exploited to overturn tumor fate. The molecular and cellular targets of IL-8 should be brought into the attention of even more intense scientific exploration and valorization in the therapeutical management of melanoma. |
| first_indexed | 2024-03-10T03:45:43Z |
| format | Article |
| id | doaj.art-bd023293e4014aa0b2f820c00cf85023 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T03:45:43Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bd023293e4014aa0b2f820c00cf850232023-11-23T11:20:29ZengMDPI AGCells2073-44092021-12-0111112010.3390/cells11010120Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy—An Integrated View into Other Neoplasms and Chemokine NetworksAnca Filimon0Iulia A. Preda1Adina F. Boloca2Gabriela Negroiu3Group of Molecular Cell Biology, Institute of Biochemistry of the Romanian Academy, 060031 Bucharest, RomaniaGroup of Molecular Cell Biology, Institute of Biochemistry of the Romanian Academy, 060031 Bucharest, RomaniaGroup of Molecular Cell Biology, Institute of Biochemistry of the Romanian Academy, 060031 Bucharest, RomaniaGroup of Molecular Cell Biology, Institute of Biochemistry of the Romanian Academy, 060031 Bucharest, RomaniaCutaneous melanoma accounts for only about 7% of skin cancers but is causing almost 90% of deaths. Melanoma cells have a distinct repertoire of mutations from other cancers, a high plasticity and degree of mimicry toward vascular phenotype, stemness markers, versatility in evading and suppress host immune control. They exert a significant influence on immune, endothelial and various stromal cells which form tumor microenvironment. The metastatic stage, the leading cause of mortality in this neoplasm, is the outcome of a complex, still poorly understood, cross-talk between tumor and other cell phenotypes. There is accumulating evidence that Interleukin-8 (IL-8) is emblematic for advanced melanomas. This work aimed to present an updated status of IL-8 in melanoma tumor cellular complexity, through a comprehensive analysis including data from other chemokines and neoplasms. The multiple processes and mechanisms surveyed here demonstrate that IL-8 operates following orchestrated programs within signaling webs in melanoma, stromal and vascular cells. Importantly, the yet unknown molecularity regulating IL-8 impact on cells of the immune system could be exploited to overturn tumor fate. The molecular and cellular targets of IL-8 should be brought into the attention of even more intense scientific exploration and valorization in the therapeutical management of melanoma.https://www.mdpi.com/2073-4409/11/1/120interleukin-8chemokinesCXCL8CXCR1CXCR2chemokines in tumor progression |
| spellingShingle | Anca Filimon Iulia A. Preda Adina F. Boloca Gabriela Negroiu Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy—An Integrated View into Other Neoplasms and Chemokine Networks Cells interleukin-8 chemokines CXCL8 CXCR1 CXCR2 chemokines in tumor progression |
| title | Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy—An Integrated View into Other Neoplasms and Chemokine Networks |
| title_full | Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy—An Integrated View into Other Neoplasms and Chemokine Networks |
| title_fullStr | Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy—An Integrated View into Other Neoplasms and Chemokine Networks |
| title_full_unstemmed | Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy—An Integrated View into Other Neoplasms and Chemokine Networks |
| title_short | Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy—An Integrated View into Other Neoplasms and Chemokine Networks |
| title_sort | interleukin 8 in melanoma pathogenesis prognosis and therapy an integrated view into other neoplasms and chemokine networks |
| topic | interleukin-8 chemokines CXCL8 CXCR1 CXCR2 chemokines in tumor progression |
| url | https://www.mdpi.com/2073-4409/11/1/120 |
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