Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
Mus81-Mms4 endonuclease is critical for processing various DNA recombination structures. Here the authors uncover a regulatory mechanism of the endonuclease via posttranslational modifications involving SUMOylation and ubiquitylation that impact on genome integrity.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19503-4 |
| _version_ | 1818952152602640384 |
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| author | Anja Waizenegger Madhusoodanan Urulangodi Carl P. Lehmann Teresa Anne Clarisse Reyes Irene Saugar José Antonio Tercero Barnabas Szakal Dana Branzei |
| author_facet | Anja Waizenegger Madhusoodanan Urulangodi Carl P. Lehmann Teresa Anne Clarisse Reyes Irene Saugar José Antonio Tercero Barnabas Szakal Dana Branzei |
| author_sort | Anja Waizenegger |
| collection | DOAJ |
| description | Mus81-Mms4 endonuclease is critical for processing various DNA recombination structures. Here the authors uncover a regulatory mechanism of the endonuclease via posttranslational modifications involving SUMOylation and ubiquitylation that impact on genome integrity. |
| first_indexed | 2024-12-20T09:45:50Z |
| format | Article |
| id | doaj.art-bd031adcb9114b46a9b98466291010e6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T09:45:50Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bd031adcb9114b46a9b98466291010e62022-12-21T19:44:45ZengNature PortfolioNature Communications2041-17232020-11-0111111410.1038/s41467-020-19503-4Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrityAnja Waizenegger0Madhusoodanan Urulangodi1Carl P. Lehmann2Teresa Anne Clarisse Reyes3Irene Saugar4José Antonio Tercero5Barnabas Szakal6Dana Branzei7IFOM, the FIRC Institute of Molecular OncologyIFOM, the FIRC Institute of Molecular OncologyCentro de Biología Molecular Severo Ochoa (CSIC/UAM)IFOM, the FIRC Institute of Molecular OncologyCentro de Biología Molecular Severo Ochoa (CSIC/UAM)Centro de Biología Molecular Severo Ochoa (CSIC/UAM)IFOM, the FIRC Institute of Molecular OncologyIFOM, the FIRC Institute of Molecular OncologyMus81-Mms4 endonuclease is critical for processing various DNA recombination structures. Here the authors uncover a regulatory mechanism of the endonuclease via posttranslational modifications involving SUMOylation and ubiquitylation that impact on genome integrity.https://doi.org/10.1038/s41467-020-19503-4 |
| spellingShingle | Anja Waizenegger Madhusoodanan Urulangodi Carl P. Lehmann Teresa Anne Clarisse Reyes Irene Saugar José Antonio Tercero Barnabas Szakal Dana Branzei Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity Nature Communications |
| title | Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity |
| title_full | Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity |
| title_fullStr | Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity |
| title_full_unstemmed | Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity |
| title_short | Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity |
| title_sort | mus81 mms4 endonuclease is an esc2 stubl cullin8 mitotic substrate impacting on genome integrity |
| url | https://doi.org/10.1038/s41467-020-19503-4 |
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