Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain
<p>Abstract</p> <p>The role of steroids in carcinogenesis has become a major concern in environmental protection, biomonitoring, and clinical research. Although historically oestrogen has been related to development of reproductive system, research over the last decade has confirme...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-06-01
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| Series: | Environmental Health |
| _version_ | 1818640873119809536 |
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| author | Fucic Aleksandra Gamulin Marija Ferencic Zeljko Katic Jelena Krayer von Krauss Martin Bartonova Alena Merlo Domenico F |
| author_facet | Fucic Aleksandra Gamulin Marija Ferencic Zeljko Katic Jelena Krayer von Krauss Martin Bartonova Alena Merlo Domenico F |
| author_sort | Fucic Aleksandra |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The role of steroids in carcinogenesis has become a major concern in environmental protection, biomonitoring, and clinical research. Although historically oestrogen has been related to development of reproductive system, research over the last decade has confirmed its crucial role in the development and homeostasis of other organ systems. As a number of anthropogenic agents are xenoestrogens, environmental health research has focused on oestrogen receptor level disturbances and of aromatase polymorphisms. Oestrogen and xenoestrogens mediate critical points in carcinogenesis by binding to oestrogen receptors, whose distribution is age-, gender-, and tissue-specific. This review brings data about cancer types whose eatiology may be found in environmental exposure to xenoestrogens. Cancer types that have been well documented in literature to be related with environmental exposure include the reproductive system, breast, lung, kidney, pancreas, and brain. The results of our data mining show (a) a significant correlation between exposure to xenoestrogens and increased, gender-related, cancer risk and (b) a need to re-evaluate agents so far defined as endocrine disruptors, as they are also key molecules in carcinogenesis. This revision may be used to further research of cancer aetiology and to improvement of related legislation. Investigation of cancers caused by xenoestrogens may elucidate yet unknown mechanisms also valuable for oncology and the development of new therapies.</p> |
| first_indexed | 2024-12-16T23:18:11Z |
| format | Article |
| id | doaj.art-bd03dbb6a24046dbbbadba0c108042e8 |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-12-16T23:18:11Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-bd03dbb6a24046dbbbadba0c108042e82022-12-21T22:12:14ZengBMCEnvironmental Health1476-069X2012-06-0111Suppl 1S810.1186/1476-069X-11-S1-S8Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brainFucic AleksandraGamulin MarijaFerencic ZeljkoKatic JelenaKrayer von Krauss MartinBartonova AlenaMerlo Domenico F<p>Abstract</p> <p>The role of steroids in carcinogenesis has become a major concern in environmental protection, biomonitoring, and clinical research. Although historically oestrogen has been related to development of reproductive system, research over the last decade has confirmed its crucial role in the development and homeostasis of other organ systems. As a number of anthropogenic agents are xenoestrogens, environmental health research has focused on oestrogen receptor level disturbances and of aromatase polymorphisms. Oestrogen and xenoestrogens mediate critical points in carcinogenesis by binding to oestrogen receptors, whose distribution is age-, gender-, and tissue-specific. This review brings data about cancer types whose eatiology may be found in environmental exposure to xenoestrogens. Cancer types that have been well documented in literature to be related with environmental exposure include the reproductive system, breast, lung, kidney, pancreas, and brain. The results of our data mining show (a) a significant correlation between exposure to xenoestrogens and increased, gender-related, cancer risk and (b) a need to re-evaluate agents so far defined as endocrine disruptors, as they are also key molecules in carcinogenesis. This revision may be used to further research of cancer aetiology and to improvement of related legislation. Investigation of cancers caused by xenoestrogens may elucidate yet unknown mechanisms also valuable for oncology and the development of new therapies.</p> |
| spellingShingle | Fucic Aleksandra Gamulin Marija Ferencic Zeljko Katic Jelena Krayer von Krauss Martin Bartonova Alena Merlo Domenico F Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain Environmental Health |
| title | Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain |
| title_full | Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain |
| title_fullStr | Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain |
| title_full_unstemmed | Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain |
| title_short | Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain |
| title_sort | environmental exposure to xenoestrogens and oestrogen related cancers reproductive system breast lung kidney pancreas and brain |
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